| Gene Name | OAZ2 |
|
| Specie | Tursiops truncatus | |
| Full Name | N/A | |
| Also known as | - | |
| Coordinate | chr2:106748709-106762065 | |
| Strand | - | |
| Gene summary | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| OAZ2P1 | chr2:109775616-109776697 | + |
Intergenic |
N/A | UCSC |
| >NM_001291898.1 |
| GGGGCGGGGCGGTTGCAGCGGCGTCGGCGGCGGCCGGGGAGGGTCAGTTGGAGGCAGGCGCTCgctgaggcaggaggagggctCTGGGCCCGCTGCCTGACAGGGACTTAGCCCGCAGAGCTCGGCCCCGCGTGCGCGCGCGACCCCACACCCGCCCACTCATCCACCTACCCACTCCCTGCGCCGCCTCTTCCCACCCTGAGCAGAGCCGCCGAGGATGATAAACACCCAGGACAGTAGTATTTTGCCTTTGAGTAACTGTCCCCAGCTCCAGTGCTGCAGGCACATTGTTCCGGGGCCTCTGTGGTGCTCCTGATGCCCCTCACCCACTGTCGAAGATCCCCGGTGGGCGAGGGGGCGGCAGGGATCCTTCTCTCTCAGCTCTAATATATAAGGACGAGAAGCTCACTGTGACCCAGGACCTCCCTGTGAACGATGGAAAACCTCACATCGTCCACTTCCAGTATGAGGTCACCGAGGTGAAGGTCTCTTCCTGGGATGCAGTCCTGTCCAGCCAGAGCCTGTTTGTAGAAATCCCAGATGGATTATTAGCTGATGGGAGCAAAGAAGGATTGTTAGCACTGCTAGAGTTTGCTGAAGAGAAGATGAAAGTGAACTACGTCTTCATCTGCTTCAGGAAGGGCCGGGAAGACAGAGCTCCACTCCTGAAGACCTTCAGCTTCTTGGGCTTTGAGATTGTGCGTCCAGGCCATCCCTGTGTCCCCTCTCGACCAGATGTGATGTTCATGGTTTACCCCCTGGACCAGAACTTGTCCGATGAGGACTAATGGTCATAGAGGATGCTTTGCCCAAGAGCCACagtgagggaagaggggaagataGGCAGCCCTGGGACAGAGGAGGGAGCTTCTTGCTGTCTAGGGAAGGACGCTGAGGGGCTCAGGGTGAGGGTTGCCTGTTGTGCTCTCAGCGTTGACTCATTGAAATTGTTTTCCATAAAGAACAGTATAAACATATTATTCACATGTAATCACCAATAGTAAATGAAGATGTTTATGAACTGGCATTAGAAGCTTTTTAAACTGCGCTGTGTGATGTGCTCTATCTAGCCTAGGGGAGGACATTGCCTAGAGGGGGAGGGACTGTCTGGGTCCAGGGGCAAGG |