Summary

Gene Name	METAP2
Specie	Homo sapiens
Full Name	methionyl aminopeptidase 2
Also known as	MAP2|MNPEP|p67eIF2
Coordinate	chr12:95474152-95515839
Strand	+
Gene summary	The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Retrocopy(s) from METAP2

Retroname	Coord	Strand	Genomic Region	ENSG
METAP2P1	chr2:145825535-145827836	-	Intergenic	ENSG00000234119	UCSC

Expression

Transcript Sequences

>NM_006838.4

CTCATTCCCTCGCGCTCTCTCGGGCAACATGGCGGGTGTGGAGGAGGTAGCGGCCTCCGGGAGCCACCTGAATGGCGACCTGGATCCAGACGACAGGGAAGAAGGAGCTGCCTCTACGGCTGAGGAAGCAGCCaagaaaaaaagacgaaagaagaagaagaGCAAAGGGCCTTCTGCAGCAGGGGAACAGGAACCTGATAAAGAATCAGGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAAGATAAAGAAAGAGATGAAGATGATGAAGATGGAGATGGCGATGGAGATGGAGCAACTGGAaagaagaagaaaaagaagaagaagaagaGAGGACCAAAAGTTCAAACAGACCCTCCCTCAGTTCCAATATGTGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAATGCGAATACCCACCCACACAAGATGGGCGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGTTCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTTCCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACTCCCAATGCCGGTGACACAACAGTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATAAGTGGTAGGATTATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCTGTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATTGATGTTCGTCTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGATGGGAAGACATATCAAGTGAAACCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACATGCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACAAGAATGGAGGAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGATGATATGGAATGTTCACATTACATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACAAAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTTGCCTTCTGCCGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGTGACTTGGGCATTGTAGATCCATATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAACATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTATTTTCTGAGCTTTGTTGGAAAACATGATACCAGAATTAATTTGCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATACTTTTATCCATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTAATGTAATTAACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTGTTTTTCCCCTTCCTGTCTAGGAAAATGCTATAAAGCTCAAATTAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTAAGAGATACTTTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTGAATGACTACATCCAGTTCTGCACCTATACCCTCTGGTGTTGCTTTTTAACCTTCCTGGAATCCATTTTCTAAAAAATAAAGACATTTTCAGATCTGAGAGCTACATCTCAATGTCTGTGGTTATAATTCTGGACAGGATAAATAGCTAAACTTAATGTAGGCAAATGCAGAGACATTTATCTGAAATGTAGACCTCTACACTGAGACTTTTCTGGCATAGTGGCTAAAACAAGATCTACACATGCATAAAAAGGGACAATCACCTTTTCTTCATAAATATACAGCTTTAGGAATATTTCACCATTCTTTGTAGGACATAGTAGTCCTTGTCTTTTTTTCTCCTGACATTGGAAAGATGTGCTAATTGAAACTTGACTTAGTAGGAACATTGTGCCAACTCAAAACCTTGATTTAGTAAAAATCTCAATGTTTAGATCCTTTGTCCAGTGGTGGTGTTTATCAGGGAATGTATTCAGCTTGCTCAGAAAACCAAAAGGGTATTAAAGCCACAAAAGCAAAGAAGAAAAAAAAAAACTTCCCATGTTTGGATCTTGTTCTAGTTAGAAAAATTAAGTTGAAATTCTTGGACTTTTTCATTCATGAGGCAAATGCTGTAATACCTTCCCCTTTGACAGGTTTGGATTCTTAACATTACTAGTGGTATTTCAGGAAGTGACGTTACAGTTACTTTCCTTATAGCGGCTAAGTGTATTAAGTTGAATGTAACGATGGTAATATTAATTTGTTTGAACTGAGGCCCACTACTGATTCTTTGACAAATTGAATTCTTATATTTAAATAATTTTATGGGAATGTTCCATCATAATTTCTAAATCATTTATATATCAAGGTAGCCTTAATTTGTATATGTTTCAGTACAATGAGATTTTATTGCCTCTGGGATGCTGTTTAGTTTGTATTTTGTTGAACGTTTTTATCCTAGGAAGAGAAACCTATGACTTGTGTACCTAGATCATCTGTTACATTAAAAAGCTGCTCTTTCAGCATTAGAGCTATAAATGAATGTTACCTTGTCGGGAAACAATCTAGGTTTTAGCTGTATGAGCTATGTTTATTATGGTGCTAATGTTCAGTAGCCACATTTGACTAATGTCTCCATTCTCTGTGATGCTGTGGCTAGCAGCAGAGCTCGCCAGTTCATGCCTGGACATACTGTCAGGGCTGGGCCCTCCAGCTAGCTCCTTTGGGGTTGAGTCCGTATCTTTTTGATGTGGAAGTATAAAGCAAGTATCTTGATTTCTAAACCCAGCAATTTTAGAATTGACCTTTATGAGTGAAGACTTTTGGAGCTTTTAAAGACCTTGGCAGTCATGATCTCAAACCAATTAGGAGCTCCAAGCTCCCTTCCCAGGTAACTGTTGGGAGCAATGGCATCACTGTATGCCCTTGTAATGGCTGGAAGGGACATGATCTTGTAAGTAGGAAAGCTGTAACTAAAAATTGTATTGTTTGCTTATTAGCCATGTATCTCTTAAAATTTTGTTATGTTTACAACGATGTACCTTATTGGCAACAAGTTATTAGTTTGATGTTTAACAATAGTGCCTTTAGTAAATTATTTTACAACTAAAA