Summary

Gene Name	Cdk4
Specie	Mus musculus
Full Name	cyclin-dependent kinase 4
Also known as	Crk3
Coordinate	chr10:126899404-126903157
Strand	+
Gene summary	Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to interleukin-4; cellular response to lipid; and regulation of lipid metabolic process. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin D2-CDK4 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Cdk4

Retroname	Coord	Strand	Genomic Region	ENSG
Cdk4P2	chr10:34089708-34090239	-	Intergenic	ENSMUSG00000111876	UCSC
Cdk4P3	chr14:91436832-91437364	-	Intergenic	ENSMUSG00000115225	UCSC
Cdk4P1	chr6:132046263-132046496	-	Intergenic	ENSMUSG00000108144	UCSC
Cdk4P4	chrX:151327115-151328290	-	Intragenic Intragenic	ENSMUSG00000083948	UCSC

Expression

Transcript Sequences

>NM_001355005.1

AACGTCCGGCGCCCGCCCCGCCCCCCGGGTTTCCGCGCGCCTCTctggcagctggtcacatggtgagggtgggggtgagggggcctCTCTAGCTCGCGGCCTGTGTCTATGGTCTGGCCCGAAGCGTCCAGCTGCCCGGGACCGATCCCCGGTGTATGGCGCCGCAGGAACCGGCTCCCGGGCCCAGATAAAGGGCCACCTCCAGAGCTCTTAGCCGAGCGTAAGGCTGATGGATGTCTGTGCTACTTCCCGAACTGATCGGGACATCAAGGTCACCCTAGTGTTTGAGCATATAGACCAGGACCTGAGGACATACCTGGACAAAGCACCTCCACCGGGCCTGCCGGTTGAGACCATTAAGGATCTAATGCGTCAGTTTCTAAGCGGCCTGGATTTTCTTCATGCAAACTGCATTGTTCACCGGGACCTGAAGCCAGAGAACATTCTAGTGACAAGTAATGGGACCGTCAAGCTGGCTGACTTTGGCCTAGCTAGAATCTACAGCTACCAGATGGCCCTCACGCCTGTGGTGGTTACGCTCTGGTACCGAGCTCCTGAAGTTCTTCTGCAGTCTACATACGCAACACCCGTGGACATGTGGAGCGTTGGCTGTATCTTTGCAGAGATGTTCCGTCGGAAGCCTCTCTTCTGTGGAAACTCTGAAGCCGACCAGTTGGGGAAAATCTTTGATCTCATTGGATTGCCTCCAGAAGACGACTGGCCTCGAGAGGTATCTCTACCTCGAGGAGCCTTTGCCCCCAGAGGGCCTCGGCCAGTGCAGTCAGTGGTGCCAGAGATGGAGGAGTCTGGAGCGCAGCTGCTACTGGAAATGCTGACCTTTAACCCACATAAGCGAATCTCTGCCTTCCGAGCCCTGCAGCACTCCTACCTGCACAAGGAGGAAAGCGACGCAGAGTGAGAAGAGGGGCTGCCTTTCCCAGTCTTGGTGGAGAAACCCTCGCTGAAGCGGCAGCCTCTGTTTCCCCCCAAGGCTGTGGAGAATCCTCCAGTTTTTTACAGAGAATATTTTAAGCCTTAAATAACAAGTCCCCACCTCTCCTTACGAGGTTCACCCCCATTACCCTCCCCTAGCTCTACACTAAAGGGCAGGTGTAtctgtcttcttccctccctgATTTATACTGGGATCTTTTTTATAcaggaaaacaagacaagacaaagagta

>NM_009870.4

AACGTCCGGCGCCCGCCCCGCCCCCCGGGTTTCCGCGCGCCTCTctggcagctggtcacatggtgagggtgggggtgagggggcctCTCTAGCTCGCGGCCTGTGTCTATGGTCTGGCCCGAAGCGTCCAGCTGCCCGGGACCGATCCCCGGTGTATGGCGCCGCAGGAACCGGCTCCCGGGCCCAGATAAAGGGCCACCTCCAGAGCTCTTAGCCGAGCGTAAGATCCCCTGCTTCGAGAATGGCTGCCACTCGATATGAACCCGTGGCTGAAATTGGTGTCGGTGCCTATGGGACGGTGTACAAAGCCCGAGATCCCCACAGTGGCCACTTTGTGGCCCTCAAGAGTGTGAGAGTTCCTAatggaggagcagctggagggGGCCTTCCCGTCAGCACAGTTCGTGAGGTGGCCTTGTTAAGGAGGCTGGAGGCCTTTGAACATCCCAATGTTGTACGGCTGATGGATGTCTGTGCTACTTCCCGAACTGATCGGGACATCAAGGTCACCCTAGTGTTTGAGCATATAGACCAGGACCTGAGGACATACCTGGACAAAGCACCTCCACCGGGCCTGCCGGTTGAGACCATTAAGGATCTAATGCGTCAGTTTCTAAGCGGCCTGGATTTTCTTCATGCAAACTGCATTGTTCACCGGGACCTGAAGCCAGAGAACATTCTAGTGACAAGTAATGGGACCGTCAAGCTGGCTGACTTTGGCCTAGCTAGAATCTACAGCTACCAGATGGCCCTCACGCCTGTGGTGGTTACGCTCTGGTACCGAGCTCCTGAAGTTCTTCTGCAGTCTACATACGCAACACCCGTGGACATGTGGAGCGTTGGCTGTATCTTTGCAGAGATGTTCCGTCGGAAGCCTCTCTTCTGTGGAAACTCTGAAGCCGACCAGTTGGGGAAAATCTTTGATCTCATTGGATTGCCTCCAGAAGACGACTGGCCTCGAGAGGTATCTCTACCTCGAGGAGCCTTTGCCCCCAGAGGGCCTCGGCCAGTGCAGTCAGTGGTGCCAGAGATGGAGGAGTCTGGAGCGCAGCTGCTACTGGAAATGCTGACCTTTAACCCACATAAGCGAATCTCTGCCTTCCGAGCCCTGCAGCACTCCTACCTGCACAAGGAGGAAAGCGACGCAGAGTGAGAAGAGGGGCTGCCTTTCCCAGTCTTGGTGGAGAAACCCTCGCTGAAGCGGCAGCCTCTGTTTCCCCCCAAGGCTGTGGAGAATCCTCCAGTTTTTTACAGAGAATATTTTAAGCCTTAAATAACAAGTCCCCACCTCTCCTTACGAGGTTCACCCCCATTACCCTCCCCTAGCTCTACACTAAAGGGCAGGTGTAtctgtcttcttccctccctgATTTATACTGGGATCTTTTTTATAcaggaaaacaagacaagacaaagagta