Summary

Gene Name	Itgb2
Specie	Mus musculus
Full Name	integrin beta 2
Also known as	2E6|Cd18|LAD|LCAMB|Lfa1|MF17
Coordinate	chr10:77366164-77401542
Strand	+
Gene summary	Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Itgb2

Retroname	Coord	Strand	Genomic Region	ENSG
Itgb2P1	chrX:67825326-67826474	-	Intragenic Intragenic	ENSMUSG00000083046	UCSC

Expression

Transcript Sequences

>NM_008404.5

AGACACAACCACACAGCCAGCTGGCAAGAAGTAGGCAAAGACATCTCCAGTCAGATTCTCGGAGTGGAGGCTTCCTGGGACTGAGAGGGGGACATGCTGGGCCCACACTCACTGCTGCTTGCCCTAGCTGGACTGTTCTTCCTGGGATCTGCTGTGTCCCAGGAATGCACCAAGTACAAAGTCAGCAGTTGCCGGGACTGTATCCAGTCGGGGCCTGgctgttcctggtgccagaagcTGAACTTCACTGGACCAGGAGAACCTGACTCCTTGCGCTGTGACACACGGGCACAGCTGCTGCTGAAGGGTTGTCCAGCCGATGATATCATGGACCCCAGGAGCATCGCTAATCCTGAGTTCGACCAACGGGGGCAACGGAAACAGCTATCTCCACAAAAAGTGACACTTTACTTGCGACCAGGACAGGCTGCCGCATTCAATGTGACTTTCCGGCGGGCCAAGGGATACCCCATTGATCTGTACTACCTCATGGATCTCTCCTACTCCATGCTTGATGACCTCAACAACGTCAAGAAGCTGGGCGGGGACTTGCTGCAGGCCCTCAACGAGATCACCGAGTCTGGCCGCATCGGCTTTGGGTCGTTTGTGGACAAGACGGTGCTGCCTTTTGTTAACACCCATCCTGAGAAGCTGAGGAACCCATGTCCCAACAAGGAGAAGGCCTGCCAGCCCCCATTTGCCTTTCGGCACGTGCTCAAGTTAACCGACAACTCCAACCAGTTTCAGACAGAGGTCGGCAAGCAACTGATTTCCGGAAACCTGGACGCCCCTGAGGGTGGGCTGGATGCCATAATGCAAGTTGCTGCATGTCCGGAGGAAATTGGCTGGCGCAATGTCACGAGGCTGCTGGTGTTTGCCACAGACGATGGCTTCCACTTTGCTGGTGATGGCAAACTGGGTGCCATCCTGACCCCCAATGATGGCCGCTGCCACCTGGAGGATAACATGTACAAGAGGAGCAATGAGTTCGACTACCCATCCGTGGGTCAGCTGGCACACAAACTTTCCGAGAGCAACATCCAGCCCATCTTTGCGGTGACAAAGAAGATGGTGAAAACGTATGAGAAACTCACGGAGATCATCCCCAAGTCAGCAGTGGGGGAACTGTCTGACGACTCCAGCAACGTGGTGCAGCTCATCAAGAATGCCTACTATAAACTCTCCTCTAGAGTCTTCCTGGACCACAGCACCCTCCCGGACACCCTGAAAGTCACCTATGACTCCTTCTGCAGTAATGGAGCATCGAGTATAGGCAAATCCCGTGGGGACTGTGATGGCGTACAGATCAACAACCCGGTCACCTTCCAGGTAAAGGTCATGGCTTCCGAGTGTATCCAGGAGCAGTCCTTTGTCATCCGGGCACTGGGTTTCACGGATACAGTGACCGTGCAGGTCCGTCCCCAGTGTGAGTGTCAGTGCCGGGACCAGAGTCGGGAGCAGAGTCTCTGTGGAGGCAAGGGAGTCATGGAGTGTGGTATCTGCAGGTGTGAGTCTGGCTACATTGGGAAAAACTGTGAGTGCCAGACTCAGGGTCGGAGcagccaggagctggagagaaacTGTCGGAAGGACAATAGTTCCATCGTGTGCTCAGGGCTTGGGGACTGCATCTGTGGGCAGTGTGTATGCCATACCAGTGACGTCCCCAACAAAGAGATCTTTGGGCAATACTGCGAGTGTGACAATGTCAACTGTGAGAGATATAACAGCCAAGTCTGCGGTGGCTCAGATCGGGGTTCCTGCAACTGTGGCAAATGTAGTTGCAAGCCCGGTTACGAGGGCTCGGCCTGCCAGTGTCAGAGGTCCACCACGGGCTGTCTGAATGCACGGCTGGTAGAGTGCAGTGGCCGTGGCCACTGCCAATGCAACAGGTGCATATGTGACGAAGGCTACCAGCCACCGATGTGTGAGGATTGTCCCAGCTGTGGCTCGCACTGCAGGGACAACCACACctCTTGTGCCGAGTGCCTGAAGTTTGATAAGGGCCCTTTTGAGAAGAACTGTAGTGTTCAGTGTGCTGGTATGACGCTGCAGACTATCCCTTTGAAGAAAAAGCCCTGCAAGGAGAGGGACTCGGAAGGCTGTTGGATAACTTACACTTTGCAGCAGAAGGACGGAAGGAACATTTACAACATCCATGTGGAGGACAGTCTAGAGTGTGTGAAGGGCCCCAATGTGGCTGCCATCGTAGGGGGCACCGTGGTAGGTGTCGTACTGATTGGTGTCCTCCTCCTGGTCATCTGGAAGGCCCTGACCCACCTGACTGACCTCAGGGAGTACAGGCGCTTTGAGAAGGAGAAACTCAAGTCCCAATGGAACAATgacAACCCCCTCTTCAAGAGTGCTACGACAACGGTCATGAACCCCAAGTTTGCTGAAAGCTAGAGCATGAGTTATCATAATCAAGCAGATGTGACCCCCTCAGACCACGCCTCCTCCCCTCTGCAAACACAACGTGGCTTACAGCTCACCCCAGTGCTGCCAAGGATCCAAAAGCCTGCTCGGTTTCTTTCCGCCATTATATCAAGTCTGCCAGGGTTTCCAGGGACTTGTCTTCCGACCTGCACAATCTTGCCGCAGAGCCCTAAGAATTGTCCCGAGTCCCAAGAGGTTCCACCCACATTTTCTTGCATAAAGGAAGACAGCAGTCTCAGTAAAGGTGGCCCcaacttatttatatttaaacttGTCAGAGTATAAAACTCCTATTATATTGTTAACATCCCATCTGTTGTATTATATGTGAGTATAAAAACTATATCCAACGTATTATTTCATAATCatgtatgaaaaataataaagcttCCATCCATGCTGTCCATGGAAGGTAAGCTTTGTGGAGTCTTTTGGGGC