| Gene Name | Lmnb2 |
|
| Specie | Mus musculus | |
| Full Name | lamin B2 | |
| Also known as | - | |
| Coordinate | chr10:80737197-80754079 | |
| Strand | - | |
| Gene summary | This gene encodes a protein component of the nuclear lamina, which provides a structural framework for the nuclear envelope. Defects in this gene were found to cause abnormalities in the shape of neurons. This locus represents one of two B-type lamin genes that may be partially, but not entirely, functionally redundant in neuronal development. Loss of both B-type lamin genes in keratinocytes results in ichthyosis and a skin barrier defect leading to dehydration. Alternative transcriptional initiation and splicing results in multiple transcript variants and protein isoforms, including an isoform with a shorter N-terminal rod domain that may function in nuclear envelope remodeling during spermatogenesis. A related pseudogene is found on chromosome 5. [provided by RefSeq, Sep 2017] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| Lmnb2P1 | chr5:19709080-19711073 | - |
Intragenic |
ENSMUSG00000106204 | UCSC |
| >NM_010722.5 |
| GGCGCCATCTTCCGCGGCGCGGATTGAATGAGCGCGCCGCATTCGGGCAACCGAGGTGATTCTCCCGCCGCCGCCACCTCCGCCATGGCGTCTCTGCCGCCCCACGCGGGGCCCGCCACGCCGCTGTCGCCCACGCGTCTGTCTCGGctgcaggagaaggaggagctcCGTGAGCTCAACGACCGCCTGGCACACTACATCGACCGTGTCCGCGCGCTGGAGCTGGAGAATGATAGGTTGCTGCTCCGGATCTCCGAGAAGGAGGAGGTGACCACTCGCGAGGTGAGTGGCATCAAGACCCTGTACGAGTCAGAGCTGGCTGACGCCCGACGGGTACTGGATGAGACGGCCCGTGAACGTGCCCGGCTGCAGATTGAAATTGGAAAGGTGCAGGCTGAGCTAGAGGAGGCCAGGAAGAGTGCCAAGAAGCGGGAAGGTGAGCTCACAGTGGCCCAGGGCCGAGTGAAGGATCTGGAATCACTGTTTCACCGGAGTGAGGCTGAGCTGGCCACAGCCCTCAGTGACAAGCAGGGCCTGGAGACAGAGGTGGCAGAGCTTCGAGCACAGCTGGCCAAGGCAGAAGATGGTCATGCTGTGGCCAAGAAGCAGTTGGAGAAGGAGACGCTGATGCGTGTGGACCTGGAGAACCGATGCCAGAGCCTGCAGGAGGAGCTGGCTTTCAGCAAGAGTGTGTTTGAGGAGGAGGTACGGGAGACCCGACGGAGGCACGAGCGGCGCTTGGTGGAGGTGGACAGCAGCCGGCAACAGGAATATGACTTCAAGATGGCTCAGGCCCTGGAGGACCTGCGCAGTCAGCACGATGAGCAAGTGCGCCTGTACCGGGTAGAACTGGAGCAGACCTACCAGGCCAAGCTGGACAACGCCAAGCTGCTCTCGGACCAGAATGACAAGGCAGCCCATGCAGCCCGCGAGGAGCTCAAGGAGGCCCGCATGCGCGTGGAGTCCCTCAGCTACCAGCTTTTAGGCCTCCAAAAGCAGGCCAGTGCTGCAGAGAACCACATCCATGAGCTGGAGGAGGCCTTGGCTGGGGAGCGTGACAAGTTCCGCAAGATGCTGGACGCTAAGGAACAGGAGATGACGGAGGTGCGGGACGCCATGCAGCAGCAGCTGGCAGAGTACCAAGAGCTGCTGGACATTAAGCTGGCCCTGGACATGGAGATAAGCGCCTACCGCAAGCTGCTGGAGGGCGAGGAGGAGAGGCTGAAGCTGTCTCCCAGCCCTTCATCACGGATCACCATCTCTCGGGCCACAtcgagcagcagcagcagcagcggggTTGGCATGTCTGTGGGCCAGGGCCGGGGCAAGCGCCGGCGGCTGGAGACTGAGGACACCTCAGGCTCACCCAGCAGGGCTTCCAGAGTGAGCAGCGGCTCCCGCCTGGCTCAGCAGACTGTGGCCACGGGTGTTGTGAACATCGACGAGGTGGACCCAGAGGGCAGGTTCGTGCGCCTTAAGAACTCTTCAGACAAGGACCAGTCTTTGGGGAACTGGAGGATCAAGAGACAGGTTCTGGAGGGTGAGGACATTGCCTACAAGTTCACACCCAAGTATGTCCTGCGGGCCGGCCAGACTGTCACGGTGTGGGCAGCTGGCGCAGGGGCTACCCACAGTCCCCCATCAACCCTTGTGTGGAAAAGCCAGACCAACTGGGGCCCTGGGGAGAGCTTCCGCACTGCCCTGGTCAGTGCCGACGGTGAGGAGGTGGCCGTGAAGGCTGCAAAGCACTCATCTGTCCAGGGGAGGGAGAacggggaagaggaggaagaggaagaggcagaattCGGTGAAGAGGACCTCTTCCACCAGCAGGGGGACCCAAGGACTACCTCAAGGGGCTGCCGACTGATGTGAAACCTGCCCCACGGTCACCATGGTCCCCAGAGCCCCTAAAACTACTTTTTTATGGTCTGCTCTCACTAGTCCTTGGTCTGTTTCTCGATGACTGTTAAGCAACCATGAGAATGTGGGTGGGCTCTGCTGGGTTTCCGAGATGGAGGTGCCCTCTGCCCACCGGCCTGACCTGGCCCCATGCCGTCAAGATGGTATAGAGGCCTGGGGCTAGGAACCCGCAGGCTGAGGGACTTGGGCCTGGATCTGGGGCAGGAGAATGGCTGCTAGCTCAGGGTGGACTTTGTATGAAACTGGTGATTCAGTTGTTTTCTTTGAAGCctttcaaatcaaatcaaattcagAATCCAAGAGTGCTGTGGGGCCCACTAGCCTGTCAGGATGTGGTGGCTCTTAGGACACAGGGCAGACCCTCCTCTCCTGGAGTTGATGGCACCTGAAACCAGGGATGGCCCAGCTTTGTGCTCTGAATCTGAAGGGTTTATAACAGTCCCCAGCTCCAGGGCATTCACAGGCTTCTCTGGTCCCAGATTCTGAATTGTTCTAGTCCCTTCTAAAGCGGAGGACCAAGGAGGAGCGAGTTCACACATGGGACGACGCCTCCCATCCTAAGACTGAAGGGGACAGGCAAACCGTGGGCGTTGTGCCTTCAGGAGCAAAGGCTGCAGGTTCCCAGCCAGTGACTGCTCACATGAGTGTGGCCACACTAGCTATGCTCCTGGCCTCTCCTGTATGAATACTGTGTGGCCCCTCTGTGCCCCACCTCGATGGCAAGGCCTGGAAACTTGCTTCCCTGCAACTTAGTGCCAGGAGCCAGCCAGTTTCACCTGTCACCTCCCCACCACTGACacatggtatttttttaaagaatatttatttttttacatcgGTCAGTAACGCAGCTCACTGGGATGATGCTCTGGGGGTTCAGGCCTGGAGCTGCCACAACTGGCAGCTTCCTTTACTGAGCTAGGGCgagttctttctctctcctggcaCAGCTGATGGTAGGAAGAGTCCAGGCCTAGTCTTCCCCCAAGGCAAGAGCTCTTGGCCACAGgatgccaccactgccaccaacCTCCAGAACCCACCAGCCACCTCCTGCTTCTAGATACCTCCGTTTTCTTTGTGACCGGCGTTGGATCCTGGATAGTTATGGCTGGCTGCAGTCACTGCGCAGCTCTGCTGCCTTGCCCACAGGGCAGGTGTACTCTGCACTGGAGCTAGCTTCCTTGTATTTGAGGAGCAGGTCTAGAGTAATCTGCAGGTCCTCAGGGGTCTGTTTCTGGCCCTGGCTAGGTGAGATGGTTACCGGAGTGGCACTGCTGCTGGGGAGCCGCCGGCACTGCGCACATCGCTCAGCTCTACAGATTGTTTCTTTTATAAGATGCATGCCAAACGTGTGTTCCACCTTTTCTTTTACGCCTATGATTTGTAATATACATTTTACAACTGGAAACTTTTGTATACTCAAATAAACATTGACTTTAACTGCA |