Summary

Gene Name	Mpz
Specie	Mus musculus
Full Name	myelin protein zero
Also known as	Mpp|P-zero|P0
Coordinate	chr1:170978282-170988699
Strand	+
Gene summary	This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2015]

Retrocopy(s) from Mpz

Retroname	Coord	Strand	Genomic Region	ENSG
MpzP1	chr6:57958053-57959317	-	Intragenic Intragenic	N/A	UCSC

Expression

Transcript Sequences

>NM_008623.5

TGTGTTCCGGGCTTGGTGGAtgTGTTTCTTGATCTTCAAGATGGACGCGACACAATTCAGTGCCAGCTACCTCAAAACATAAGTTTCATGTTGGTAGCAGTGGCtgtgcctatagtcccagcactgtggaggctgagACACTCTGGGCCTTTGCCCTACCCCAGCTATGGCTCCCGGGGCTCcctcctccagccccagccctatcCTGGCTGCCCTGCTCTTCTCTTCTTTGGtgctctctccagccctggccatTGTGGTTTACACGGACAGGGAAATCTATGGTGCCGTGGGCTCCCAGGTGACCCTGCACTGCTCCTTCTGGTCCAGTGAATGGGTCTCAGATGACATCTCTTTTACCTGGCGCTACCAGCCTGAAGGGGGCCGAGATGCCATTTCGATCTTCCACTATGCCAAGGGACAACCTTACATCGATGAGGTGGGGACCTTCAAAGAGCGCATCCAGTGGGTAGGGGACCCTCGCTGGAAGGATGGCTCCATTGTCATACACAACCTAGACTACAGTGACAACGGCACTTTCACATGTGATGTCAAAAACCCACCGGACATAGTGGGCAAGACCTCTCAGGTCACGCTCTATGTCTTTGAAAAAGtGCCCACTAGGTATGGGGTGGTGTTGGGAGCAGTGATCGGGGGCATCCTCGGGGtggtgctgttgctgctgttgctcttCTACCTGATTCGGTACTGCTGGCTGCGCAGGCAGGCTGCCCTGCAGAGAAGGCTCAGTGCCATGGAGAAGGGGAGATTTCACAAATCTTCGAAGGACTCCTCGAAGCGAGGGCGGCAGACGCCAGTGCTGTATGCCATGCTGGACCACAGCCGAAGCACCAAAGCTGCCAGTGAGAAGAAATCAAAAGGGCTGGGGGAGTCTCGCAAGGATAAGAAATAGCGGTTAGCGGGCCGGGCGGGGGGTCGGGGGTCTGCGACGGAGTCCTCCAAAGGCTCTCAGGTGGTGGTCATCGAGATGGAGCTTCGCAAAGATGAGCAGAGCTCGGAGCTCCGGCCTGCAGTCAAGTCCCCCAGTAGAACCAGCCTCAAGAACGCCCTCAAGAACATGATGGGCCTGGACTCGGACAAGTGACCGTCACATCCAGGCCCTGTCAGAGCAGGGGACCTAGGCTCCTCTTTTTCCCGGGTCTAGGTGCTTTCCTCTTGCTCctcagccctgccctgcccttacCTCCCAATGAGATGTAAAGTTTCATTCCAACCTTCCTTTCCAAGTCTTGTACTCCTCCTTCGCCTTTACCCCTCGGCTTTCCAGGAGCCTAGGGACTAACCCTACTCCTCGCCTGCCCCAAGGGCTGTGTGTTTGGTGCCTGTCTCTCAGACACCGAGAAGAAAGGGACCTTGATAGCCTCTGCCCAACTCCAGGCCACTTGGCCTTCCCatctctcccccccccgcccccccccccagctgatCCCCTGGCTCCTTCCTGCTCTCCCTTTCCTACCTTCTGGTGGCCCAGCTCCACACTCTGTCCTCGGGCTCAAATCCACATCGTGCAGAGCAGACTCTCCATCAGGGTTTATTTAGGTTGCTGAGTATTTTTTATTTGCCCATCCATTCTTTCGTTTGTTTACCTGAGCCCACGGCCCCATGACCGAGGACCAATGACGTCATGTGGCTTTTGCAGTTCCCCACTAAGTCTTTACTGGAGAGCCAGGCAGGCAAGCAGCGCATAATCGATGCCCTCTGACCACTACGGAGCACAGTTCTGGGACTCCGAGAtttggggaaggaaagaaaaaaaaatggatcctCACAGGTCAGGGGTGCAGTAGGGGGCTTTAAGAAATGTCTTCAAAATAAATAATCAGAACAGGAAACGCCAGCGAgaatgggaaggaaaggaagtggCTACACCCCCGGGCACAGTGGACTGTTAGGACTTTTCTACATTCTGTATATTTCTCCTACCATCTCCAAATGTCCTTAAATGTTTAATAAACACTGACATTTCCAGAAGCTGC