Summary

Gene Name	Oaz2
Specie	Mus musculus
Full Name	ornithine decarboxylase antizyme 2
Also known as	AZ-2|AZ2|Oaz2-ps|Sez15
Coordinate	chr9:65583830-65597582
Strand	+
Gene summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Retrocopy(s) from Oaz2

Retroname	Coord	Strand	Genomic Region	ENSG
Oaz2P2	chr15:52122357-52123321	+	Intergenic	ENSMUSG00000115738	UCSC
Oaz2P1	chr3:135230645-135232399	-	Intragenic	ENSMUSG00000083610	UCSC

Expression

Transcript Sequences

>NM_010952.3

GGCGGTTGCGCGGCGGCGGCCGGGGAGGGTCAGTTGGAGGCAGGCGCTCGCTGAGGCAAGAGGAGGGCACTCGGCCCGCGGCCTGACAGGGACTTAGCCCACAGAGACCGGCCCGCGCGCGcgaccccacacccacccactcgtccacctacccactccccgcGCCGCCTCCTCCCACCCTGAGCAGAGCCACCGAGGATGATAAACACCCAGGACAGTAGTATTTTGCCGTTGAGTAAGTGTCCCCAGCTCCAGTGCTGCAGGCACATTGTTCCAGGGCCTCTGTGGTGCTCCTGATGCCCCTCACCCACTGTCGAAGATCCCCGGTGGGCGAGGGGGCGGCAGGGATCCTTCTCTCTCAGCTCTAATATATAAGGACGAGAAGCTCACTGTAACCCAGGACCTCCCTGTGAACGATGGAAAACCTCACATCGTCCACTTCCAGTATGAGGTCACCGAGGTGAAGGTCTCTTCCTGGGATGCAGTCCTGTCCAGCCAGAGCCTGTTTGTAGAAATCCCAGATGGATTATTAGCTGATGGGAGCAAAGAAGGATTATTAGCACTGCTAGAGTTTGCTGAGGAGAAGATGAAAGTGAACTACGtcttcatctgcttcaggaaGGGCCGGGAAGACAGAGCTCCACTCCTGAAGACGTTCAGCTTCTTGGGCTTTGAGATTGTGCGTCCAGGTCATCCCTGTGTCCCCTCTCGGCCAGATGTGATGTTTATGGTTTACCCCCTGGACCAGAACTTGTCTGATGAGGACTAATGGTCACAGAGGATGCTTTGCCTAAGAGCCAcagtgggggaagaggggaagttAGGCAGCCTTGGGACAGAGGAGAGGGTCTCTGGCTGTCTAGGGAAGGACATTGAGGGGCTCAGGTTGAGGGTTGCCCATTGTGTTCTCGGAGTTGACTCGTTGAAATTGTTTTCCATAAAGAACAGTATAAGCATATTATTCACATGTAATCACCAATAGTAAATGAAGATGTTTATGAACTGGCATTAGAAGCTTTTTAAACTGCGCTGTGATGTGCTCCATCTACCCTAGGGGAGGACATTGCCTGCAGGGGCGGGACTGCCGGGCCCAGGACAGGCCTGGAGGGCTGGTGGGCAGGACTGTCAGGCTCAGGTCTCCTTGGAGTTgggctttcttcttttggttttgaagacttaggtattttctttctttgcttcttgtcATCTAGGGGCTCCTGAGTATAGGCTTTAGCTCCTGGGCAGTGTCCTTGGGTTGTCTTCAACACTCCACCTTGAGCTTCTGGCATTTTGTGTCTGGCCTGGTGTAAGCAGGTCTGACCTTGCTTTCTTTACAGCTTAGTGTTATTCTGGCATTTGGTTAAGCTGGCTTAATCTGTTTAATGTTACCAGTGCATTTTAAATAGGGGCATTGAAACTCACTCCCCCACACCAGGGCTTTTTGGGGGGTGCCTGGGCCTTAAGAAACTAGCCAAACTACATCTCAAGTTACCACCAGAGCTCTTGCCTCTGTGGCCTAGGCCCCAGGATCTCTTTCCTTGcaagagcagagaggaagaatACCAAACTCAGGGCCTGGGGTTTGTGGGGGAGCCTGTTCTTAGCGCCTGGATGCCTCTGGCTGGCCAAGCACAGTACTGCCTGCCTCCTTAACAGGTTCAGAACAGTGCCTGCGCTGCAGAGCTGAGAGGTAGGGCTGGACTGCAGAAATGGCCTGCCTTTTACTGCTTTCACCAAACAGCTTGTtctaaagagaaaagggagagagatctACATTGGGTGTGGGGGTGTCAGGGAGACAAGTGTGTTGTGTTACTGTGTCAATAAACTGATTTAAAGTTGTG