Summary

Gene Name	Pfn1
Specie	Mus musculus
Full Name	profilin 1
Also known as	Pfn
Coordinate	chr11:70542670-70547625
Strand	-
Gene summary	Enables small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton and synapse maturation. Acts upstream of or within neural tube closure and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Pfn1

Retroname	Coord	Strand	Genomic Region	ENSG
Pfn1P1	chr15:10917570-10917906	+	Intergenic	ENSMUSG00000115042	UCSC
Pfn1P2	chr18:3446975-3447481	+	Intergenic	ENSMUSG00000117370	UCSC

Expression

Transcript Sequences

>NM_011072.4

gggggggggaggagcagGAAGTGGCGGTGCGAGGGCTGCTGCACAGCTAACAGAGCCGCGTTCCGGACGGCAGCGCGTGCCCCGAGCTCTCTGCCTTCCCCCGCCCGCCAGCCCGAGCCCGAGCCCGCGATCCCAGCAACAGCCCGCAGAGCAGCCCCAGCAGCAGCGCCATGGCCGGGTGGAACGCCTACATCGACAGCCTTATGGCGGACGGGACCTGTCAGGACGCGGCCATCGTAGGCTACAAGGACTCGCCCTCCGTCTGGGCCGCCGTCCCCGGGAAGACCTTCGTTAGCATTACGCCAGCTGAGGTTGGTGTCCTGGTAGGCAAAGACCGGTCAAGTTTTTTCGTCAATGGGCTGACACTTGGGGGCCAGAAATGTTCTGTGATCCGGGACTCACTGCTGCAAGACGGGGAATTTACAATGGATCTTCGTACCAAGAGCACCGGAGGAGCCCCCACCTTCAATGTCACTGTCACCATGACTGCCAAGAcGCTAGTCCTGCTGATGGGCAAAGAAGGTGTCCACGGTGGTTTGATCAACAAGAAATGTTATGAAATGGCCTCTCACCTGCGGCGTTCCCAGTACTGACCTCATCTGTCCCTTCCCCCCACCGTTCCCTTTGGCTTTTGCACCCCCTTctttccatacacacacataccattatTTTTTGGGCCATTACCCCATTTCCCTTATTGCTGCCAAAACCAcatgggctgggggctggggctggatgGACAGACACCTCCCCCTACCCATACcccctcctgtgtgtgtttggaaaatttttgtttttgggtttcattttttgttttttggtcttttttttttttttttttttctgaataaaaaaAGATTCTACTAACAA