Summary

Gene Name	FEN1
Specie	Homo sapiens
Full Name	flap structure-specific endonuclease 1
Also known as	FEN-1|MF1|RAD2
Coordinate	chr11:61792911-61797238
Strand	+
Gene summary	The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Retrocopy(s) from FEN1

Retroname	Coord	Strand	Genomic Region	ENSG
FEN1P1	chr1:91328249-91330256	+	Intragenic	ENSG00000215873	UCSC

Expression

Transcript Sequences

>NM_004111.6

GGCTGAACGTCAGGCCACCCGCCGCTAAGCTGAGAAGGGAGAGCGAGCTTAGGACCGCCTGCCCGGGGCAACCCCGAACCAAGCTTTAGCCGCCGAGGCCGCGTGTCCCAAAGGCCAGTCATCCCTCCTCTGTGTTGCCATGGGAATTCAAGGCCTGGCCAAACTAATTGCTGATGTGGCCCCCAGTGCCATCCGGGAGAATGACATCAAGAGCTACTTTGGCCGTAAGGTGGCCATTGATGCCTCTATGAGCATTTATCAGTTCCTGATTGCTGTTCGCCAGGGTGGGGATGTGCTGCAGAATGAGGAGGGTGAGACCACCAGCCACCTGATGGGCATGTTCTACCGCACCATTCGCATGATGGAGAACGGCATCAAGCCCGTGTATGTCTTTGATGGCAAGCCGCCACAGCTCAAGTCAGGCGAGCTGGCCAAACGCAGTGAGCGGCGGGCTGAGGCAGAGAAGCAGCTGCAGCAGGCTCAGGCTGCTGGGGCCGAGCAGGAGGTGGAAAAATTCACTAAGCGGCTGGTGAAGGTCACTAAGCAGCACAATGATGAGTGCAAACATCTGCTGAGCCTCATGGGCATCCCTTATCTTGATGCACCCAGTGAGGCAGAGGCCAGCTGTGCTGCCCTGGTGAAGGCTGGCAAAGTCTATGCTGCGGCTACCGAGGACATGGACTGCCTCACCTTCGGCAGCCCTGTGCTAATGCGACACCTGACTGCCAGTGAAGCCAAAAAGCTGCCAATCCAGGAATTCCACCTGAGCCGGATTCTGCAGGAGCTGGGCCTGAACCAGGAACAGTTTGTGGATCTGTGCATCCTGCTAGGCAGTGACTACTGTGAGAGTATCCGGGGTATTGGGCCCAAGCGGGCTGTGGACCTCATCCAGAAGCACAAGAGCATCGAGGAGATCGTGCGGCGACTTGACCCCAACAAGTACCCTGTGCCAGAAAATTGGCTCCACAAGGAGGCTCACCAGCTCTTCTTGGAACCTGAGGTGCTGGACCCAGAGTCTGTGGAGCTGAAGTGGAGCGAGCCAAATGAAGAAGAGCTGATCAAGTTCATGTGTGGTGAAAAGCAGTTCTCTGAGGAGCGAATCCGCAGTGGGGTCAAGAGGCTGAGTAAGAGCCGCCAAGGCAGCACCCAGGGCCGCCTGGATGATTTCTTCAAGGTGACCGGCTCACTCTCTTCAGCTAAGCGCAAGGAGCCAGAACCCAAGGGATCCACTAAGAAGAAGGCAAAGACTGGGGCAGCAGGGAAGTTTAAAAGGGGAAAATAAATGTGTTTCCCCATTATACCTCCTTCACCCCAGAATATTTGCCGTCTTGTACCCTTAAGAGCTACAGCTAGAGAAACCTTCACGGGGTGGAGAGAGGATTCTAAGGCTTTTCTAGCGTGACCCTTTTCAGTAGTGCTAGTCCCTTTTTTACTTGATCTTAATGGCAAGAAGGCCACAGAGGTACTTTTCCTTTTTTAGCTCAGGAAAATATGTCAGGCTCAAACCACTTCTCAGGCAGTTTAATGGACACTAAGTCCATTGTTACATGAAAGTGATAGATAGCAACAAGTTTTGGAGAAGAGAGAGGGAGATAAAAGGGGGAGACAAAAGATGTACAGAAATGATTTCCTGGCTGGCCAACTGGTGGCCAGTGGGAGGTGATGGTGGACCTAGACTGTGCTTTTCTGTCTTGTTCAGCCTTGACCCACCTTGAGAGAGAGCCACCAGGAAGGCGCATCTTAGCAGATGGGAGGAACTGCTGAGAGAAGATGGGCAGAAAGCTGGAGCCCCTGGAGTtggctgtgtctgtgtttgtgactgattactggctgtgtctTGGGTGGGCAGAAACTCGAACTTGCTATGTAATTTGTGTCTAGTTATTCAGAGGAGTAAGATGGTGATGTTCACCTGGCAATCAGCTGAGTTGAGACTTTGGAATAAGACACTGGTTTTCATGCGCTGTTTTTGTTTTAAAGTTATGAAGAAAAAAGTCAATAAAATTCTAAAAGTAA