Summary

Gene Name	Vhl
Specie	Rattus norvegicus
Full Name	von Hippel-Lindau tumor suppressor
Also known as	Vhlh
Coordinate	chr4:145580869-145587835
Strand	+
Gene summary	Predicted to enable enzyme binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of catecholamine metabolic process; and response to ethanol. Located in cytosol; mitochondrion; and nucleus. Part of VCB complex. Used to study Parkinsonism. Biomarker of nephroblastoma and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to several human genes including VHL (von Hippel-Lindau tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Vhl

Retroname	Coord	Strand	Genomic Region	ENSG
VhlP1	chr20:1897587-1897952	+	Intergenic	N/A	UCSC

Expression

Transcript Sequences

>NM_052801.1

CCGCGTTAAAGCCGGACGGAGTACTTCTATTGCTGGCAGACCTGCCCCGGAGCGCGTAAACCCGCACGCTCGCGCCGCCCACGTCCAGCTCGCGAATCCGGAGGCGTCCGGTTCCAATAATGCCCCGGAAGGCAGCTAGTCCAGAGGAGGCAGAAAGGATGCCGGGCTCTGAAGAGATAGAGGCTGGGCGGCCGCGGCCGGTTTTACGCTCTGTGAACTCGCGCGAACCCTCTCAGGTCATCTTCTGCAACCGCAGCCCGCGCGTCGTGCTGCCTTTGTGGCTCAACTTTGATGGTGAGCCTCAGCCCTACCCGACCTTACCACCGGGCACCGGCCGCCGCATCCACAGCTACCGAGGTCACCTTTGGCTCTTCAGGGATGCGGGGACCCATGATGGACTTCTGGTTAACCAAACGGAACTGTTTGTGCCATCCCTCAATGTTGATGGACAGCCTATTTTTGCCAACATCACATTGCCAGTGTATACCCTGAAAGAGCGGTGCCTTCAGGTTGTACGGAGCCTGGTCAAGCCTGAGAACTACAGGAGGCTGGACATCGTCAGGTCGCTCTATGAAGACTTGGAAGACCACCCAAATGTGCGGAAAGACATACAGCGGCTGACCCAAGAGCACCTCGAGAATCAGGCCCTGGGAGAGGAGCCTGAAGGAGTCCACTGAGATTACTGGTCCTGAATTTCGGCCTTGATGGTCTGAAATTGATCTACACATAGGACAGGTCACTTTCTTTCGGTTTTAAAATGGTTCATTCTTGGAGTAAAATATCCATCATGTAAAAGAAAGTTAACTAACATCACTGAGCTTTGTAGTGTTTAAGACTAAACCTGCAAAGTGCCACCGAGTCTGCCCTTTCTAGAGCATTCATCAGAAGAAGCTGTTTTCAGTTTTGCTTCCTAGTAAGGCTGGATGTTCAGCATAAGGATGTTAGTGTGAGCAATTCGCAGGAGTTGCTCTGTGTCCTCTAATCTGAAGAATACAGCCTCGTATGAACAGAGCCCCACCGCTCACTTGGGGAAGGCTGAGAAGGCCCTAATGCTGGGATGGACATCCTGTAGAGGCCCAGTGCCTAATGTGTGTGGAGTCTTCAGTCAGTGTTGGAGGAACAAACCATTGGGTACTTAGTGGGAGAGTTGGAGGGCCTGGCTCTCTGTCTGAGGAAATCTTAAGTGTACATGTAAAGGAACAGCTTAGCAGCTTCTGTTTAGAAAGAACTTTCTCTTGAGTTTCCATGTCTCAGCACTTTCTTTCTACTTTGTTAGTTTATTTTAttttatttttgagacttgtgtagcccaggtcagcctcagtcactccggaggggatgctggtcttgaattccggatcctctgggagtgtgtcagcattgggagcacatgggtgcaccacAGTCTGCTCTGTTCTTGCTTTTCCCAttttgagacgggctcatactgtagccctgcctggcctcaagctagagtcagccctgtctccccacccagtctggCTGCTTAGACTGGGTGGGCTTCCCATATTCACTGCCCCAGACAGCAGAGACGAGCTGTCCTTGTGTTTAGGTCTGGTTTTGAGAGTTCCTTCTCTGAGGAAGCTGCTGGCAGGAGCAGGGTTTCTGTTCCTTCCCGTCAGCCCCTAGCATTCCAACTGGGCGCCGCACTCTGCTTTGGCAGGCGCTAGTTATGCTTCGATGGGAGAGGGGAGTGAAGCTCCCCTCAGCCACACACTCCAAACCATGGGTCCCAGAGCAGTCTGCAATGAGTAGTAGTTTGTGGGCAGTCACAGCTTTTCTTACATATTCAAATATTGATGTTCACTACTTCTATCAAACATTTTGTAGAACATAATTTTTTATTTGTTTTTAATTCCTCAGCAGAGAAAAATGAGAGAAGCTTGGGCATTGTGTGTGGCACACACCAGAAAGGACAGTCAGCTGAGAGGGTGCAGAAAGGCTCTTGTGCGCTGGCTCTCAGCTGCATGTAGTCCTGTAACCCAGTGTTCTCTCTAGTACACATTTTAATTGGTTAAAGCACTTTGTCCTGGCCgagatcataaggtatatacagttttgtggcctgatttttcattgaacttcatTGttttgttttcccctctttttcgtttttggttttgtttttggtttgttttttgCTttttgttttatcaagatagagtttctctgtgtagcccaggctgtcctggaactccctttgtagaccaaacaactgattactggcctcaaacggagatctgtctgcctctgcctctccagtgctgggattgaagTATGCCTAATCTTCATCTAACTTAGTAACTTGTCTTTTCCATGTTACTGCACACACTGTCTAAATTCCGGTGTGCTAGCCTCTCCCTTTGAGGGTGACTGTTGGGAGTATTTGTCTCAGTCCTGGGCTCCTTGAGTGCAGTCTGATGCTCTAAGATCAGCAAAATCACTGAACTTAATACTGACACTCCTGCCGCCCTCTCAGCGTCTCTCCTTAGTCTGCAGCATTCCATGAGTGAAGGGGCCACAGGCCAGTGTGGAGCCTGTGTGTGGGAAGTCAGCAGGTGCCGAGCTATTGCAACATTGGTTTTATTTTTTAAACCTATCTCTGTCTCTAAAAGATGTAATGTTTGTCTTATTTAACTGGAAGTTTGAATACTGTTCTCTGTGCCTTAGGACATGAGTCACTTGTCCTTGCACATCCTGTAAGTGTGTTCCTCAGACTTTGTACTCTCCTTTGAGTTCTCTGAAAAAGCTGACCTTTAGTACAATAAACGGTGCTAAGTGAAGGA