Summary

Gene Name	Selenow
Specie	Rattus norvegicus
Full Name	selenoprotein W
Also known as	SelW|Sepw1
Coordinate	chr1:77530692-77535765
Strand	-
Gene summary	This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 10. [provided by RefSeq, Aug 2017]

Retrocopy(s) from Selenow

Retroname	Coord	Strand	Genomic Region	ENSG
Sepw1P1	chr10:48498080-48498687	+	Intragenic	N/A	UCSC

Expression

Transcript Sequences

>NM_013027.3

GCGCACGGCCCCACGCGCAGAGATTGAAGTCCTTGCTGCTAGTGGGTCGGGTCCTCGCTTTGTGCGGGGATGCGACGTGCAGCAATGGCGCTAGCCGTTCGAGTCGTGTATTGTGGAGCTTGAGGCTATAAGCCCAAGTATCTCCAGCTCAAGGAGAAGCTAGAACATGAGTTCCCCGGATGCCTGGACATCTGTGGCGAGGGGACTCCCCAGGTCACCGGGTTCTTTGAAGTGACGGTAGCCGGGAAGTTGGTTCACTCCAAGAAGAGAGGTGATGGCTACGTGGATACAGAGAGCAAGTTCCGGAAACTGGTGACTGCCATCAAAGCCGCCTTGGCTCAGTGCCAGTGAGCCCTAGAGGCAGGGTCCTGAAGGCTCCTGGCCGGCCTTTCTTGGCAGCCGCTTCATGACAGGAAGGACTGAAATGTCTCAAAGACCTGTGGTCTTTCTTCGATGTTCCTGCGGCCACCAAGTCAGGCCAGAGATGGATTCTGTGTGTGGGTGCCTTCCCAGAATCTACCTGTGCACGCACCCCGCCCTGCCCTCCCGCCCTCTTCCTCACCTCTCTCTGAATTCCCCCATGTTTCCTACCTTCCCTCCTGCTTTGGTTTCCCGTCTCCCCCTCAAGACTGCAAGAAGACGGGCAGCCGTGTCGCCAGGTGttcctggttgaataaaggttggccaaggcaacctgag