| Gene Name | GCSH |
|
| Specie | Homo sapiens | |
| Full Name | glycine cleavage system protein H | |
| Also known as | GCE|NKH | |
| Coordinate | chr16:81081945-81096395 | |
| Strand | - | |
| Gene summary | Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| GCSHP5 | chr1:168055358-168056493 | - |
Intragenic |
ENSG00000224837 | UCSC |
| GCSHP6 | chr1:190797614-190797903 | + |
Intergenic |
ENSG00000238108 | UCSC |
| GCSHP2 | chr14:103184373-103184667 | + |
Intergenic |
ENSG00000259525 | UCSC |
| GCSHP3 | chr2:206115558-206116563 | - |
Intergenic |
ENSG00000237580 | UCSC |
| GCSHP7 | chr3:49252129-49252275 | - |
Intragenic |
ENSG00000270538 | UCSC |
| GCSHP9 | chr5:141895625-141896695 | - |
Intergenic |
ENSG00000226040 | UCSC |
| GCSHP8 | chr5:26670337-26670482 | - |
Intergenic |
ENSG00000250703 | UCSC |
| GCSHP1 | chr5:39888182-39888933 | - |
Intergenic |
ENSG00000248651 | UCSC |
| GCSHP10 | chr7:35765657-35768649 | - |
Intergenic |
ENSG00000232736 | UCSC |
| GCSHP11 | chr7:64582695-64584291 | + |
Intergenic |
ENSG00000224669 | UCSC |
| GCSHP12 | chr9:6276638-6277005 | + |
Intergenic |
ENSG00000228132 | UCSC |
| >NM_004483.5 |
| ACCGCCTCCGCGCCTCCATCCAGCCGGCTCCCTCCGGCCGCGAACTGCCCCTCCCCGCCCCGCCTCCCGGCGCGGGTGGCCGAGGCGTAGCGCTGCGACCCCCGCACCCCTGCGAACATGGCGCTGCGAGTGGTGCGGAGCGTGCGGGCCCTGCTCTGCACCCTGCGCGCGGTCCCGTCACCCGCCGCGCCCTGCCCGCCGAGGCCCTGGCAGCTGGGGGTGGGCGCCGTCCGTACGCTGCGCACTGGACCCGCTCTGCTCTCGGTGCGTAAATTCACAGAGAAACACGAATGGGTAACAACAGAAAATGGCATTGGAACAGTGGGAATCAGCAATTTTGCACAGGAAGCGTTGGGAGATGTTGTTTATTGTAGTCTCCCTGAAGTTGGGACAAAATTGAACAAACAAGATGAGTTTGGTGCTTTGGAAAGTGTGAAAGCTGCTAGTGAACTCTATTCTCCTTTATCAGGAGAAGTAACTGAAATTAATGAAGCTCTTGCAGAAAATCCAGGACTTGTAAACAAATCTTGTTATGAAGATGGTTGGCTGATCAAGATGACACTGAGTAACCCTTCAGAACTAGATGAACTTATGAGTGAAGAAGCATATGAGAAATACATAAAATCTATTGAGGAGTGAAAATGGAACTCCTAAATAAACTAGTATGAAATAACGCAAGCCAGCAGAGTTGTCTTAAATTAGTGGTGGATAGAAGACTTAGAATAGAAACTTTTAGTATTACCGATGGGGAAAAAAAAACTACTGTTAACACTGCTAATGAAAGAAAATGCCCTTTAACTTTCTAATGATTATAGATAAATATAATATGCGTCTTTTTCACAATATCCTATGATTTTTAGACTAGGCTCTAGTGTTCAGAATTCATGAAATTATCCATGGTAAAAACTAGTTATAAAAATTACATAATTCAAAGATAACATTGTTATTCTTAAGCCTTATATAATATTGTAACTTGCATGTATCCATACCTGGATTTGGGATGAAATACTTAATGATCTTTCCATTGGAAATAACTGGAAGTGAAGAGGTTTTGTTGCTTGTACAGTGTCAGATGAGGAACACCACTATCTTAATTTTGCGATACACTGCATTTGCTGGTGCTATTTTTATACAGTGAAGCAACAGCTTTGCAGCAAAATAATAAAATACTTCTTCGTTAATCATGTTTGTTTTGATGTTAATATTTCATTTAGTAACTCTGCTAGTATTTGTGAAAGTGCTAACTTTAACTTACGGAAAGTTACTTTTTAAAAGGAAATTTAAGCCAGAACAATGCAAAGCTCCAAGAAAATGTTTTCTTTAGTCACAAATCTGGTTTTTCTTAAGCCAAGATCTGTCACCTTTAACATAATAAAAAATAAATCACCAACTTTGATTTTCTATCATGCGAGGTCTGAAGAAAGAAGAGGAAAGACAGAGGAAGGTGGAAGTTTTGATCAGTATAGCACATGGTGTTTTTAAGTTGTTAAACCACGTTCAGGTTTCCACTTAAGTCATGGGAATAAAAGTGGACAAGGACTGAAGCTTTATGAGCTCAGA |