| Gene Name | Selenok |
|
| Specie | Rattus norvegicus | |
| Full Name | selenoprotein K | |
| Also known as | Selk | |
| Coordinate | chr16:6035926-6044240 | |
| Strand | + | |
| Gene summary | The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Aug 2017] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| SelkP1 | chr8:76479309-76479999 | - |
Intergenic |
N/A | UCSC |
| SelkP2 | chr13:208433-209208 | - |
Intragenic |
N/A | UCSC |
| SelkP3 | chr14:79189246-79189704 | - |
Intragenic |
N/A | UCSC |
| SelkP4 | chr15:85292006-85292538 | + |
Intergenic |
N/A | UCSC |
| SelkP5 | chr18:36095757-36096427 | + |
Intergenic |
N/A | UCSC |
| SelkP6 | chrX:71141478-71142104 | + |
Intergenic |
N/A | UCSC |
| SelkP7 | chrX:77981248-77981903 | - |
Intergenic |
N/A | UCSC |
| >NM_207589.3 |
| GACGTAAGGGTGGGGCGGGAGGGGAGGTACGGCAACATCAGGGCGTCCGGTCTTCTCTGTCGCTAGGAAGCGGGCAACCGGAGGAAAGATGGTTTACATCTCGAATGGTCAGGTGTTAGACAGCCGGAATCAGTCCCCCTGGAGATTGTCTTTCATAACAGATTTCTTCTGGGGAATAGCAGAATTTGTGGTTTTTTTTTTCAAAACTCTGCTTCAGCAAGATGTGAAGAAAAGAAGAGGCTACGGGGGCTCCTCTGATTCCAGATATGATGACGGAAGAGGGCCACCAGGAAACCCTCCACGAAGAATGGGTCGGATCAGTCACCTTCGTGGCCCCAGCCCTCCTCCAATGGCCGGTGGATGAGGAAGGTAAACGTCTGCTCTGAGAAGCAGACAACTAGACATACACGCCTAGAAGGGAACCATCAAGAGGTGAGGAGCGGCTCATGAGGAGAAGATGGTGTATGTCCAAACAAGGACTGCTCTGTGTCCTCACAGAAGAATGAGGTCATGCTGGGAACTCCCTCTGCAGGATCTGGCCTGACTGATGTGCAGTTCTATAAATGTACATGTGTGTCTCCTTATCTGTTTTGTATAGTTCACTAAAGTTAATATAGATTTAAGAAGTAAATATTTTTAGGTTGCAAAACTTGATTCTTCATCTTTATATGATTATACCCAAAATCCTTGATCTGGAAGAAATAAAGGCCATGTAGTTAGTCCTGGA |