Summary

Gene Name	MRPL22
Specie	Homo sapiens
Full Name	mitochondrial ribosomal protein L22
Also known as	HSPC158|L22mt|MRP-L22|MRP-L25|RPML25
Coordinate	chr5:154941073-154969411
Strand	+
Gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Retrocopy(s) from MRPL22

Retroname	Coord	Strand	Genomic Region	ENSG
MRPL22P1	chr4:56320745-56321241	-	Intragenic	ENSG00000250324	UCSC

Expression

Transcript Sequences

>NM_014180.4

GCTTGAACTCGGCGGCTTCCGTAGCGGGAGGGCGAAAGATGGCGGCGGCAGTACTGGGACAGTTGGGTGCGTTATGGATACATAACCTGAGGAGCCGGGGGAAGCTGGCCTTGGGTGTTTTACCTCAATCATATATCCACACAAGTGCTTCTCTTGACATTTCTCGAAAATGGGAGAAGAAGAATAAAATTGTTTATCCTCCACAACTGCCTGGAGAACCTCGGAGACCAGCAGAAATCTACCACTGTCGAAGACAAATAAAATATAGCAAAGACAAGATGTGGTATTTGGCAAAATTGATACGAGGAATGTCTATTGACCAGGCTTTGGCTCAGTTGGAATTCAATGACAAAAAAGGGGCCAAAATAATTAAAGAGGTTCTCTTAGAAGCACAAGATATGGCAGTGAGAGACCATAACGTGGAATTCAGGTCCAATTTATATATAGCTGAGTCCACCTCAGGACGAGGCCAGTGCCTGAAACGCATCCGCTACCATGGCAGAGGTCGCTTTGGGATCATGGAGAAGGTTTATTGCCATTATTTTGTGAAGTTGGTGGAAGGGCCCCCACCTCCACCTGAGCCACCAAAGACGGCAGTTGCCCATGCCAAAGAGTATATTCAGCAGCTTCGCAGCCGGACCATCGTTCACACTCTATGATGAGGAGATTCAGACTCCACAGTGTATATATTTTGCCATTTATTTTCTAAAAATAAACAAAAATTGAAGGCAAATGCTTTTTATGATTTCTCATTGAATTATTGAAACAGTGTATAACTGCTAGTTGTAAATGAATATTTATAAGGCTTTGCCCATTTCTTTTGAGCCTCTGGGCATATTTGTATGCATTTGCGACTTGGAAGGGGAAATCAGCTTTAAACATAGTAACAGACTATATTTCAAAAGGCTTTTGGAGTAACTTTGAAAGGGAATGTTAACTTTCCAACTAGTGTCCTGCAGGTGGCTGTTTTGATACTGGACTTGAATACAGTGTTATGAGGTAAGAAAATTGCTTTTATTTCACTTAATTTTCTCTTGGGACCATGGGAAGTTAGAGTGGCTGCATGTTGTTTCATTACAGTATTTTAGGGTGTTCAGTGGTACCGTTTTTCCTTTCACTGTTGGCACAGGCCAGTGAGTCAAAAATTATATTTTCCTTTACTGTTTTAGCAGTAACTCGAAACTACAGGAGTTTATTAGATATACGAATCTAAAACTCCAAAAACCTTTAACTTTGAAAATTTTCTTTTGGTTAAGCAAAGCCTGTTTTTATTTCTTCTTCCAACAGTGCTTTATATTGTTTGGATATCTTGTTTAGGATTGATTTATTTTTCAGGGTAAATTCAATTACTGAGAGAGGAATTGAACCAATCTCAGCATTGCATTCTAAAATGGGGCAGTAGGTGGCACTCAACCTTTTATTAGCAGAAAATTGTTAGTTTCAAATTAGAGTGTTCAACACTGCTTCCCTCTCATTCATACACGTCTTCATTAAGAAGAAGTACTCTTTGTCTACAGCCCTAGtccaacttttgcatgcaaaagaagaatcgaggatgcttgcttgttaatgcagacttctgggccccaccccaatgattcaattcactaggtcttatggggggctggtttcagaaatctatgttttaaacaaacacttccaggtaattctgttgtaggggactacgctttgagaaTACGGCTTTAGGAGAATGAAAAAATGTAGTTTTATTGCCATGTTTTAAGATGGCATTaataatagttactgtttactgggaacttgttatttgcaagctctgtgctagtattttacataattcttcacaacatcctgaaaatgtagcttttgttttaccactttacaaaggaataaaccgaagcacacagaattcaaataactatcacaagtcacacagcatgtaaatattggggctatgattgaaaggtttCTAAAGTAGCTGGTTCTGCATACCTTTTGAGTATACAGCTGGGTTTTTGTGTCTCTCCAGTTAACCTAATGCATGGGTAAAAAGACATCAGGGGTCAGTGGAATAAACCAAGGTGTAGGACAGATTCATTCTGGGTCCTAAGCTGTTGTAGCATGgagtcagggaaataacactggaatattaaaaggtaaccttcattctagtctgtgcattctcattagccagaaagaagactggataggtctcttcccttgctggcctccatttcattcatttatgaaacaagagactcaatgttctctGTAGAAAACCTTTTttagaatcacttgaagaatttgtttaaaaatgcaaattcctgggctctactctcagactaagtgaatcagaagctttggtgtgggagaccatggaacctgcagttttaataaatgccccagtgatttgcatgttGGAGAATTATCACACCAGGTCACTGTGCTCTCATGTGGTGGGGATGCTCCACGATTGCTCTTGGAGTTGTGACTTCCTTGGGTGTGACTAAAGCCAGGTGGTGCCATGGACATCATAAATATAAATTATGTAAGTGAAGGCACTGCTTCAGTCAGGCTGTAAAAGCTATTTTGAAAGTGGTAAGGAAAAAGTAGGATTGTAATGAAGAAAATTTCCTTCCCAGGTTAAGCCTTCATTTGGAACTGCTTCCAGTACGTTACAAAAAGTaataatagctaacctgtgtcactgactgtatctggtactattttaagcactatatatacattatctcaatgaatcttTCCCATTGTGACATCCGGCTAGTTTTCGTGGCTAAGAGTGTACTTTCTAACATCCATGAACATTGTGGTCCCCACCTGAAGTTTCACTTTGCATGTTCAGtgatatggtttggctctgtgttcccacccaatcttatctcaaattgtaatccccatgtgtccagggagggacctgtaatccccacctagtgacggagggaggtgattgatgatgggtgtggtgtaccccatgctgttctcgtgatagtgagtgggttctcatgagatctgatggttttataagtgtttgaaagttccctcttcactcgctgtcttgcctgctgccatgtaaaatgtgcctacttcaccctctgccatgattgtaagtttcctgaggcctccccagccatgcagaactttgacacaattaaatgtcttttctttataaatta