Summary

Gene Name	Rrm2b
Specie	Mus musculus
Full Name	ribonucleotide reductase M2 B (TP53 inducible)
Also known as	p53R2
Coordinate	chr15:37924196-37961363
Strand	-
Gene summary	Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Rrm2b

Retroname	Coord	Strand	Genomic Region	ENSG
Rrm2bP1	chr13:3402793-3407386	+	Intergenic	ENSMUSG00000113636	UCSC

Expression

Transcript Sequences

>NM_199476.1

CCACCGCAGAGAAGGCCCCTCAATGGGCCGGCTAGAACCCAGGACCGGCGCGGCAAGGCGTGCCCGGAGCAGGAGGAGGTTCGCACAGGACGATCTGATCCTACTAGGATTTGGTCGGCCGCGCTCAGTTCCTCAGCTCGGGTGGCTCTGGTGGAGTCTGCGCGATGGGCGACCCGGAAAGGCCGGAAGCGGCCAGGCCGGAGAAGGGTGAGcaatTGTGTTCGGAGACAGAAGAAAATGTGGTGAGGTCAAATGAAGAGCCACTCCTAAGAAAGAGTTCCCGACGGTTCGTCATCTTTCCAATCCAGTATCCTGATATCTGGAGAATGTACAAGCAAGCACAGGCATCTTTCTGGACAGCAGAGGAGGTTGACTTGTCAAAGGACCTCCCTCACTGGAACAAGCTTAAATCCGACGAGAAGTATTTTATCTCCCACATCTTAGCCTTTTTTGCAGCCAGTGATGGAATTGTAAATGAAAACTtgGTGGAGCGTTTTAGTCAGGAGGTGCAGGTTCCAGAGGCTCGCTGCTTCTATGGCTTTCAGATTCTCATCGAGAATGTTCACTCAGAGATGTACAGTTTACTAATAGACACTTACATCAGAGATCCAAAGAAAAGggaATTTTTATTTAATGCAATTGAAACAATGCCATATGTTAAGAAAAAAGCGGACTGGGCTCTGCGCTGGATAGCAGATAGGAAATCTACTTTTGGGGAAAGAGTGGTGGCCTTTGCTGCTGTGGAAGGAATTTTCTTCTCTGGATCATTTGCTGCAATATTCTGGCTAAAGAAGAGAGGCCTCATGCCTGGACTGACTTTTTCAAATGAACTGATCAGCAGGGATGAAGGACTTCACTGTGACTTTGCCTGCCTGATGTTTCAGTACTTGGTAAACAAGCCTTCAGAAGATAGAGTGAGGGAAATCATTGCTGATGCTGTTCAAATCGAGCAGGAGTTTTTAACAGAAGCCTTGCCTGTTGGCCTCATTGGAATGAACTGTGTTTTGATGAAACAGTACATTGAGTTTGTAGCTGACAGATTACTTGGAGAACTTGGATTCTCAAAGatTTTTCAGGCAGAAAATCCCTTTGATTTTATGGAGAACATTTcattagaagggaaaacaaatttCTTTGAGAAACGAGTTTCTGAGTATCAGCGATTTGCAGTCATGGCCGAAACCACAGATAATGTCTTCACCTTGGATGCAGATTTCTAAAGCcctcctcatttaaaaaaaaaaatctatagaatTCGgctgtggtagtacatgccttagTCCAGTCCTCAGAGGAAGCTGAGGGCAcgtggatctctgggtttgaggatGATCAGGGATACATACTGAGATCTATCTCAAAAGCAACAGAACagcgaaaacaaacaaaacacatggaaACCTGTTGTTGGTAAATAGCAatctatttttgtctttttgaaacTTTCAGTATCTCATTTAAGGGAATGAGAATTTGAATAGAAGGAAATATAAAACTAAATTctaaatgatttaattttatcTAAATGTACTTCAGTTTATTTATACAATGAAAGTGTGAccaatatgtcttttttttttcctttttgtcatAAGCACTTAAGATGGCATTAAGAGCATAGATTTAGGAGTCAGGTATGAGCTTGATATTCTGGCTTACTCCTTGATGTGACCTTGGCAAGTCAGTTAGTCACTGTAAACGTCAGGATATTTATCTGTAAAATTTGTATAATAGTAAGTCCCAAGTTCATGGAGGTGACCAGAGGGCTAATATACAGAAATAGTTTGTTTATCTAATACTTTTATCTCCACTGCCTCACCTGCTAATTAATATTAGTGAGAAGATCAAGTACAGTGGCGTTGTGATGCAGTCCACTCCTCGCCAGAGAGTGACTGAGGGGTGGATTGAGATAAAGAATTCATTGAATCTTTGTGGTTTTAATGTTTGCAGGAGGAATATAAGGGTCTCCTTAGAGAGATCATAATTCTTGTCAACTGCTTTGAATTCATTAATCTGCAGTAAAGAAATAATATATAGCTCTTAATTGCTTATCGTGGGAGGCTTATGGAGTAGTAGACTCCAGGTTACCATGGTTGTGGTTCTTGTAAGCAAAGTGATTCTTCTTTAGGAATTAAAAGGATAACTGTTGCCAGGGACAGCCCAGGGGTGTTTAGAACCTGGATTGATGGGCATTTCTCAAAGTTGTCTTCTCAAACCTGGTAGATCTTCAGAGTTCTTGTGATGGAAAAAGAGATGCAGTCAGTGGGCTTGGGGAAGGCTGAGCATTCCATCCCTGCCTAGAATGCAGTCTGCAAAGCAGCTGCCCACATGTACACAACACAAGGCTGTCAGCACCTCCCACAGCTACTGAGTGCACTGGGGAAAGCTGTCCTAGAATCATTTATACACActggaaatggagaaaagaagggaggtgggagggactAGTGAACCATTTTGGATTTGTGCCAATCTGAGAAAGTGATTTAAGGTTGACGTCATCTTTATATCCTTATACTCTTAAGTCTCTACACTGTTATAAAGGAATGTTCTTTTAATGGACTGTCTATAAGGGAGATGGAAGTCTTTCTAAGAAAGATGCAGAGAGGCCAGGAGCCAGGACACCTGGGCAATGTGCCCTTCCTCATTTTCAGGAAAGTATCAAGAGGAAGCCTAAACCCCATCAAACCCGGTCCCTGGCTCAGTAAAGTTCCTGCTACTCAAGTGTGAGGTCCTGAATCCAGATCCCTAGCatagcacacacgcacacacgtacacatgcacacacgcacacaccacctgtacatgcacacatatgcacacacacagagtacaaaTAAAATGATGGCAGCTGAAATTCAGAGGTTTATCTCTGTTGAAGTTTTTATTCTATTTGCTCTACAACTATCTGATCAAAACTCGGAATCCTAAATGAATGCAAGCCATACTTCCATTGTTAAAGGGAGCACCAGAAATGAAACATGGCTCTGTGCTTCCCATTTGTCATGTTATCACCCAGTAGCCCTCTAAGCACGACAGAGTAGCTATTACTAAaacatggagagaggaaggaaggcatCAGAGAAGCTGAAAAACTTAACTTTACAGGCACTGTCCTATAATATGTTGAGACTGTTACATCCTTTAAACTTCATCCATCATGATTTATTTTGTCTATTCTTTCATTAATTAAACTATTGCATACTACTATAACAGAGTATCAAAATATCATAGAACTCGGGGTATGTGGGTAGTATATTCCAAGGTATTCATCCACTATTATACAAAAACAGCTAAAACTTAAATTACCACAGACTGAAAGAAAACAGTTTTAAAGGTGTACATTCTCAAAGTTTTAAACCCGGTTCTTCATAAGTAGTGACAGGAACCTTTATGTGATACATGTTAATAGTAGCAATAAGCAAAACTGTATTTGAAAGAAGTCTTAATTCTGAAAAACTGAATTCTTAGTACACTGTTACATTACTACTCTCAGTATTCTGTATCCCTTCAGTGCCTCCAGgttgcacatttatttattatgtttagtatTTTGGTTCTTAGATATGGAAAAATCAAgttataaaatatctttttaatatctcACAGATAACAAAAAAATCAAGGTaatgccatctctctctctctctctctctctctctttttttttacagtacatGCGTTTCAAAGAAGTGCAATTTGTCCTAGagttatgtttttatatttcaaGATGATAAACAGCTTTGTTATGACCATAGTTTAAATAAATGTTTCAACACCTAGAATCATGATGTAGAGGAACTTTGGATGAATTTTTTGCAGGGCTGAGTTTCAATAATTAAGAGTTATTTTTGTGGATAGATCACTCCCAGCCATATCTTATTATTTGAACCTGTTACAgttgtttcatttaaaaatctcCAGATTCTATTTATGTAGCtactttattatgtttattttccttcttttagttGGTGTCTCATGTGGTCTGGCCTGGATCTCACACATaaccctcttgcttcagcctcccagtcCCTGGGGTTATTGGTGTGTGATGCCATGCCCAGCTACCACTTTATGTTCTGTGCATGAAGAAATGTAGtgttcatatttaaaaataatttaatattcaaaattttgtattttatatttaaatgttattatGTCATTTTCAAAGACTCCAGATTTTTTTCACAATTAAGCAAAGACTCCAATGTCACTTCATTGATATGGAAACTCTTGATGGGCTACATTCAGGACAAATTAGTTCTAAAGTCAAAAATCATGTTTTGAATTCACTGAGGGAGTTGTCACCCAGCTCAGACAGAACTTGGGGCTGGTAATGATCATTTAACTAAATTACTAATTATTTAAACAAGTTTATTAGACATGGTGttcctaaatatattttgttaaaatacaTTATGGTAGTAAAACCAATTCTGCATGTagagtttgaggtttttttgcTCTGAAAAattatgacttttaaaataaagtttactgAAATAAA