| Gene Name | PSMC1 |
|
| Specie | Homo sapiens | |
| Full Name | proteasome 26S subunit, ATPase 1 | |
| Also known as | NEDGTH|P26S4|RPT2|S4|p56 | |
| Coordinate | chr14:90256553-90275429 | |
| Strand | + | |
| Gene summary | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| PSMC1P12 | chr1:118614108-118615668 | - |
Intergenic |
ENSG00000226126 | UCSC |
| PSMC1P8 | chr12:17383111-17384658 | - |
Intergenic |
ENSG00000256896 | UCSC |
| PSMC1P9 | chr12:18692830-18694321 | + |
Intragenic Intragenic |
ENSG00000255993 | UCSC |
| PSMC1P13 | chr13:69893855-69895387 | - |
Intragenic |
ENSG00000232314 | UCSC |
| PSMC1P10 | chr2:17385071-17386634 | + |
Intergenic |
ENSG00000236348 | UCSC |
| PSMC1P7 | chr3:161328830-161330262 | - |
Intergenic |
ENSG00000243838 | UCSC |
| PSMC1P1 | chr3:68635684-68637245 | + |
Intergenic |
ENSG00000241506 | UCSC |
| PSMC1P6 | chr3:87630156-87631664 | - |
Intergenic |
ENSG00000240255 | UCSC |
| PSMC1P5 | chr5:107195154-107195330 | + |
Intergenic |
ENSG00000250273 | UCSC |
| PSMC1P4 | chr5:56275074-56276673 | - |
Intergenic |
ENSG00000248781 | UCSC |
| PSMC1P11 | chr6:4702441-4703996 | + |
Intergenic |
ENSG00000217385 | UCSC |
| PSMC1P3 | chr7:136713841-136715412 | + |
Intergenic |
ENSG00000231244 | UCSC |
| PSMC1P2 | chr7:27461684-27463189 | + |
Intergenic |
ENSG00000213781 | UCSC |
| >NM_002802.3 |
| GGTGGAGGAACTTCCGGCAGCGGCAGCTCAAGTGGCCAAGGCAAGATGGGTCAAAGTCAGAGTGGTGGTCATGGTCCTGGAGGTGGCAAGAAGGATGACAAGGACAAGAAAAAGAAATATGAACCTCCTGTACCAACTAGAGTGGGGAAAAAGAAGAAGAAAACAAAGGGACCAGATGCTGCCAGCAAACTGCCACTGGTGACACCTCACACTCAGTGCCGGTTAAAATTACTGAAGTTAGAGAGAATTAAAGACTATCTTCTCATGGAGGAAGAATTCATTAGAAATCAGGAACAAATGAAACCATTAGAAGAAAAGCAAGAGGAGGAAAGATCAAAAGTGGATGATCTGAGGGGGACCCCGATGTCAGTAGGAACCTTGGAAGAGATCATTGATGACAATCATGCCATCGTGTCTACATCTGTGGGCTCAGAACACTACGTCAGCATTCTTTCATTTGTAGACAAGGATCTGCTGGAACCTGGCTGCTCGGTCCTGCTCAACCACAAGGTGCATGCCGTGATAGGGGTGCTGATGGATGACACGGATCCCCTGGTCACAGTGATGAAGGTAGAAAAGGCCCCCCAGGAGACCTATGCAGATATTGGGGGGTTGGACAACCAAATTCAGGAAATTAAGGAATCTGTGGAGCTTCCTCTCACCCATCCTGAATATTATGAAGAGATGGGTATAAAGCCTCCTAAGGGGGTCATTCTCTATGGTCCACCTGGCACAGGTAAAACCTTGTTAGCCAAAGCAGTAGCAAACCAAACCTCAGCCACTTTCTTGAGAGTGGTTGGCTCTGAACTTATTCAGAAGTACCTAGGTGATGGGCCCAAACTCGTACGGGAATTGTTCCGAGTTGCTGAAGAACATGCACCGTCCATCGTGTTTATTGATGAAATTGACGCCATTGGGACAAAAAGATATGACTCCAATTCTGGTGGTGAGAGAGAAATTCAGCGAACAATGTTGGAACTGCTGAACCAGTTGGATGGATTTGATTCTAGGGGAGATGTGAAAGTTATCATGGCCACAAACCGAATAGAAACTTTGGATCCAGCACTTATCAGACCAGGCCGCATTGACAGGAAGATTGAGTTCCCCCTGCCTGATGAAAAGACGAAGAAGCGCATCTTTCAGATTCACACAAGCAGGATGACGCTGGCTGATGATGTAACCCTGGACGACCTGATCATGGCTAAAGATGACCTCTCTGGTGCTGACATCAAGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATGTGTAAGTGCCCATTGGGTGGCCTGTTGGTCACTGTGCAGCAGTCTGCTTCCCAATAAAGCGTGCTCTTTCACAAACACTTCCTGTTTCTGCAGTCTCCACACACACCTACCGCTCAACAGCAGCCTGTGGGTGGACCCAGCTACAGGGAAGCCTTTGGACAGGAACTCAGGCTGCGGTCCCAAGGAGTGTGGACCTCACTATGCGTTCGCCACATCACACCCCCAGAGCTGGCGTTCAACGGTAATTACAGTGGGAAATGGTCACTACCACAGAGCCAGGGATATTCGTTGTTTAAATAATAAAGGCTGCGTTAATGTGGCTATTGCTTCCAAAGGAAGTACAGCTTTCCTTTTTGGAAGTTTTGTGGACCATGCATGTTCTTAGCACTCTGAGGGCAGAAAATAACTACTGGTGTTCCCAAGAGACTGAGGATTCCTAGAGATATCTTGAAAGCCCTTCTGAGCCCTTGGGCTCAGAAATCTCATCCCTTTCAAGGTGTTCAGAAACATGTCAGAACTTCCCCTTCCCTTTCTCCGTCTATTTCCGTCATTTCTCTTTCTGAACAAATCAGGCCTAAAGCTATTAAGTGGGACAGATCAAGGTAAGCGTTCCCTTGACAGGTGGCCTGGTGTGGGTTGTAGGGCCCACACTGAATGAGGAGTGtgtattagttttctgttaatactataacaagttaccacaggctttgtttaaaaacagcacaatttggccaggcacggtggctcacgcctgtaatcccagcactttgggaagctgaggcaggcggatcacaaggtcagaagtttgaggccagcctggccaacatggtgaaaccccatctttactaaaaatacaaaaattagctgtgcgtggtggcaggtgcctgtagtcccagctactcaggaggctgaggcaggacaatcgcttgaacccaggaggcggaggttgcagtgagccaagatcccgtcactgcactccagcctgggcgacagagcaagactccgtctcaaaaataaataaataaataaataaaaaccacaattttatctcagttctgtaggtcagaagtccaacacgagtgtctccaggctaaagtcttgctgttggcaggaccgttccctctggcgtctctaagggagaatccgtttccttgctgaggattattgttggcagaatttaatttcttggagttgtgggccagctgaggtcagcatttccttgctggctgccagctgaggcctttgccagtctgtgaaggccaccctccctcctgactcgtggcacttcattttccaccagcagcagcaggcccagtccctctctcccaccgacccttctttctgcctgccttttctattcttatggatccttgtgattgcattggacccatgcagatgatccaggataatttccctgttttaaagtttacaatcttcttaatttttatctgcaaagttccttttgccatgtaacattcacacgttccagggcttagggtgtggccatctttaggggcgccactctgcctaccacaGAGGACATCCACACGTGGGGGTGGCCCAGTGCAGGGTAAGGACGGGGTGCTTGTGGGGAGGGCGGGTGTCAGCCCAAGTAGGGTGTGGAGCTGTCCATGTGGAGGAACACCACAGCACGGGGACTCAGCATGGGCAGGGTGAGGCTGGCATCCGTGTGGGGTGTATGTGCAGGGCTGGGGTGGTCCGATAGGGGGAGTCAGTGTGGGCAGCCTGATGTGCAGTATGAGAGCCCAAGTGGGTGAGGAAGGCATCTGCAGGGACGGGGTGGTGGCAGGGGAGGGAGGCTGCTTATGTATGGAGGCAGTCAGGCAGGTAAACAGGACAGTGGGAGCCAGGTTTCTCTGAGGAGTTAGACACAGAAAGAAGAAAACAAGAACGACctctgtccactgggagcacctgggaacagtgacaccccaactgcagtgagcacccctagacccagacctttgctgctaaaagtattattctccactaaaaggagtgagggctgattccggggctaggcagggaaaggacaggatgaacccaaagtctgttttgccagaaagcaagggagtgctcaaggaatgataaggacatgtcctaaggacaccgaagcctatgtgaaggggcttccactggccaaactcgggacaatctgagcatcctaacaaacagttactattaatggaatacagtatagccctttaaataGGGAACTacacacacacacacacacacacacacacacacacacacacacacacacacacCCCAATACATATGAATTGATCtgaaagtttgctgaggaaggggtatttacagattttgagagtctgccacaaaacactgttcagttagaaagggaaagtcacactggagatgcccagcagacaccgtcttcaccaagtggtcaaatgcacatcatcagtaatgggcactttgaaagtacgtgccacccaagagtgtcagtgctgtcacactcctgccaaagatgcttagcctgaatccagtgctgaggaaacaccaggcaaacacaaactgaggaacattctacaaattcagaacacttcaaaagtatccacgtcttggaagtcaaaaagcttccaatcagaaggagaccaaagagatgacaaccaagtgcagctcctgctcctgaactggatcctTTTCCTAGAGGACATGACTGGGCCTGAGGACCTGCTAGGAGTACTGCGTCCATGCTGACTTCCTGTTCAGTGTCTGTATCGTGGGCGGGTAGCAGACTCTCAGCAACTGACTCACACGGTTCAGGAAACAAAATTCTTTGTAACGCACTTGCATCTTTTCCTAAGTTTGAGATTAAAAAAAACAAAAAACCCCA |