| Gene Name | SELENOK |
|
| Specie | Homo sapiens | |
| Full Name | selenoprotein K | |
| Also known as | HSPC030|HSPC297|SELK | |
| Coordinate | chr3:53884417-53891859 | |
| Strand | - | |
| Gene summary | The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| SELENOKP5 | chr19:10266619-10266915 | - |
Intergenic |
N/A | UCSC |
| SELENOKP1 | chr19:37693030-37693591 | - |
Intergenic |
ENSG00000267319 | UCSC |
| SELENOKP3 | chr6:118782821-118783440 | + |
Intergenic |
ENSG00000225549 | UCSC |
| SELENOKP2 | chr6:131819307-131820117 | - |
Intragenic |
ENSG00000219532 | UCSC |
| SELENOKP4 | chr7:84847825-84848156 | - |
Intergenic |
ENSG00000235243 | UCSC |
| >NM_021237.5 |
| GAGCAGAGGGAGATACAGAAACCGACAGGGGCCAGGCGCCCGGTGGCTCCGAAGCGGGGAAGTGGGACAAGATGGTTTACATCTCGAACGGACAAGTGTTGGACAGCCGGAGTCAGTCTCCATGGAGATTATCTTTGATAACAGATTTCTTCTGGGGAATAGCTGAGTTTGTGGTTTTGTTTTTCAAAACTCTGCTTCAGCAAGATGTGAAAAAAAGAAGAAGCTATGGAAACTCATCTGATTCCAGATATGATGATGGAAGAGGGCCACCAGGAAACCCTCCCCGAAGAATGGGTAGAATCAATCATCTGCGTGGCCCTAGTCCCCCTCCAATGGCTGGTGGATGAGGAAGGTAAATGTCTGCTCTAAGAAGCAGACAACCGGACATGCGCATTCATAGCAGAAGGAAACCATCAAGAAGTGGAAGGCTGACCATGATGAGCAGTAGATGAATGTGTATGTCTAAACAAGGACTGCTCTGTGTCCTCACAGATGAATGAGGTCATGCTGGGAATTCCCTCTGCAGGGAACTGGCCTGACTGACATGCAGTTCCATAAATGCAGATGTTTGTCTCATTACCTTTTTGTATAGTTTATTAAAGTATTAATATAGTTTTAATAAGTAAATATTTTTAGGTTGCAGAATGGACTCCTCATCTTTATATTCACGAAAAAGCAATCTGAAGAAAACAAATAAAAGCCTGTGTATTTAGCACTGTTAGTGTCACCTTTTCAACTTCTGAAACACTGTTCATTGTTAACTTTTTCTCATTTATAAATCACTGTATTTATTTTAGTAGTATGCATAGCATATCTGTGCTCTTGAATTAATTTTTATCTTTAACATATTTGTCTCATCAATCTTTAATACACTGTGTCTAATTTGCTACCAAATGTAATTATCAGGGTATTTATAAAACCATAGCTAACAAAACTGAGCTACAAAATGAAAATTTACTAAATAGTTTTTAAAATCATGGACTTCAgcctggcgcggtggctcatgcctgtaatcccagcactgtgggaggctgaggcgggcagatcgcctaagttcacgagtttgagaccagcctgcagcatgacgaaacctaaaataacaaaaattagccaggcgtggtagagtgcacctgtaatccctgctactcaggaggcggaggcaggagaatcgcttcaacccgggaggcggaggttgctgtgagcatgccactgcactcctgcctaggcaacagagtgagaccctgtctcaaaaaaataaataaaaCCATGGGCTTCCATGCTATCTTGACAAATTTGCACTCTATAGCATCACTCAAAATACTGCCTATtggctttaaactccatctgaatactgataactttcacattctttcactagagtggaagctctgagactaggaattttgttgtctttaccccagtcctttgaatagtgactacatgtaagatagtcatgtagtatttattggaaataaatATTTATTGGAAAAACGAAAA |