Summary

Gene Name	BCR
Specie	Homo sapiens
Full Name	BCR activator of RhoGEF and GTPase
Also known as	ALL|BCR1|CML|D22S11|D22S662|PHL
Coordinate	chr22:23180509-23318037
Strand	+
Gene summary	A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

Retrocopy(s) from BCR

Retroname	Coord	Strand	Genomic Region	ENSG
BCRP1	chr19:28079555-28079795	-	Intergenic	N/A	UCSC

Expression

Transcript Sequences

>NM_004327.4

GCAGAGTGCGGGCCGGGCGGGAGTGCGGCGAGAGCCGGCTGGCTGAGCTTAGCGTCCGAGGAggcggcggcggcggcggcggcacggcggcggcggGGCTGTGGGGCGGTGCGGAAGCGAGAGGCGAGGAGCGCGCGGGCCGTGGCCAGAGTCTGGCGGCGGCCTGGCGGAGCGGAGAGCAGCGCCCGCGCCTCGCCGTGCGGAGGAGCCCCGCACACAATAGCGGCGCGCGCAGCCCGCGCCCTTCCCCCCGGCGCGCCCCGCCCCGCGCGCCGAGCGCCCCGCTCCGCCTCACCTGCCACCAGGGAGTGGGCGGGCATTGTTcgccgccgccgccgccgcgcgggccatgggggccgcccggcgcccggggccgggctggcgaggcgccgcgccgccgcTGAGACGGGCCCCGCGCGCAGCCCGGCGGCGCAGGTAAGGCCGGCCGCGCCATGGTGGACCCGGTGGGCTTCGCGGAGGCGTGGAAGGCGCAGTTCCCGGACTCAGAGCCCCCGCGCATGGAGCTGCGCTCAGTGGGCGACATCGAGCAGGAGCTGGAGCGCTGCAAGGCCTCCATTCGGCGCCTGGAGCAGGAGGTGAACCAGGAGCGCTTCCGCATGATCTACCTGCAGACGTTGCTGGCCAAGGAAAAGAAGAGCTATGACCGGCAGCGATGGGGCTTCCGGCGCGCGGCGCAGGCCCCCGACGGCGCCTCCGAGCCCCGAGCGTCCGCGTCGCGCCCGCAGCCAGCGCCCGCCGACGGAGCCGACCCGCCGCCCGCCGAGGAGCCCGAGGCCCGGCCCGACGGCGAGGGTTCTCCGGGTAAGGCCAGGCCCGGGACCGCCCGCAGGCCCGGGGCAGCCGCGTCGGGGGAACGGGACGACCGGGGACCCCCCGCCAGCGTGGCGGCGCTCAGGTCCAACTTCGAGCGGATCCGCAAGGGCCATGGCCAGCCCGGGGCGGACGCCGAGAAGCCCTTCTACGTGAACGTCGAGTTTCACCACGAGCGCGGCCTGGTGAAGGTCAACGACAAAGAGGTGTCGGACCGCATCAGCTCCCTGGGCAGCCAGGCCATGCAGATGGAGCGCAAAAAGTCCCAGCACGGCGCGGGCTCGAGCGTGGGGGATGCATCCAGGCCCCCTTACCGGGGACGCTCCTCGGAGAGCAGCTGCGGCGTCGACGGCGACTACGAGGACGCCGAGTTGAACCCCCGCTTCCTGAAGGACAACCTGATCGACGCCAATGGCGGTAGCAGGCCCCCTTGGCCGCCCCTGGAGTACCAGCCCTACCAGAGCATCTACGTCGGGGGCATGATGGAAGGGGAGGGCAAGGGCCCGCTCCTGCGCAGCCAGAGCACCTCTGAGCAGGAGAAGCGCCTTACCTGGCCCCGCAGGTCCTACTCCCCCCGGAGTTTTGAGGATTGCGGAGGCGGCTATACCCCGGACTGCAGCTCCAATGAGAACCTCACCTCCAGCGAGGAGGACTTCTCCTCTGGCCAGTCCAGCCGCGTGTCCCCAAGCCCCACCACCTACCGCATGTTCCGGGACAAAAGCCGCTCTCCCTCGCAGAACTCGCAACAGTCCTTCGACAGCAGCAGTCCCCCCACGCCGCAGTGCCATAAGCGGCACCGGCACTGCCCGGTTGTCGTGTCCGAGGCCACCATCGTGGGCGTCCGCAAGACCGGGCAGATCTGGCCCAACGATGGCGAGGGCGCCTTCCATGGAGACGCAGATGGCTCGTTCGGAACACCACCTGGATACGGCTGCGCTGCAGACCGGGCAGAGGAGCAGCGCCGGCACCAAGATGGGCTGCCCTACATTGATGACTCGCCCTCCTCATCGCCCCACCTCAGCAGCAAGGGCAGGGGCAGCCGGGATGCGCTGGTCTCGGGAGCCCTGGAGTCCACTAAAGCGAGTGAGCTGGACTTGGAAAAGGGCTTGGAGATGAGAAAATGGGTCCTGTCGGGAATCCTGGCTAGCGAGGAGACTTACCTGAGCCACCTGGAGGCACTGCTGCTGCCCATGAAGCCTTTGAAAGCCGCTGCCACCACCTCTCAGCCGGTGCTGACGAGTCAGCAGATCGAGACCATCTTCTTCAAAGTGCCTGAGCTCTACGAGATCCACAAGGAGTTCTATGATGGGCTCTTCCCCCGCGTGCAGCAGTGGAGCCACCAGCAGCGGGTGGGCGACCTCTTCCAGAAGCTGGCCAGCCAGCTGGGTGTGTACCGGGCCTTCGTGGACAACTACGGAGTTGCCATGGAAATGGCTGAGAAGTGCTGTCAGGCCAATGCTCAGTTTGCAGAAATCTCCGAGAACCTGAGAGCCAGAAGCAACAAAGATGCCAAGGATCCAACGACCAAGAACTCTCTGGAAActctgctctACAAGCCTGTGGACCGTGTGACGAGGAGCACGCTGGTCCTCCATGACTTGCTGAAGCACACTCCTGCCAGCCACCCTGACCACCCCTTGCTGCAGGACGCCCTCCGCATCTCACAGAACTTCCTGTCCAGCATCAATGAGGAGATCACACCCCGACGGCAGTCCATGACGGTGAAGAAGGGAGAGCACCGGCAGCTGCTGAAGGACAGCTTCATGGTGGAGCTGGTGGAGGGGGCCCGCAAGCTGCGCCACGTCTTCCTGTTCACCGACCTGCTTCTCTGCACCAAGCTCAAGAAGCAGAGCGGAGGCAAAACGCAGCAGTATGACTGCAAATGGTACATTCCGCTCACGGATCTCAGCTTCCAGATGGTGGATGAACTGGAGGCAGTGCCCAACATCCCCCTGGTGCCCGATGAGGAGCTGGACGCTTTGAAGATCAAGATCTCCCAGATCAAGAATGACATCCAGAGAGAGAAGAGGGCGAACAAGGGCAGCAAGGCTACGGAGAGGCTGAAGAAGAAGCTGTCGGAGCAGGAGTCACTGCTGCTGCTTATGTCTCCCAGCATGGCCTTCAGGGTGCACAGCCGCAACGGCAAGAGTTACACGTTCCTGATCTCCTCTGACTATGAGCGTGCAGAGTGGAGGGAGAACATCCGGGAGCAGCAGAAGAAGTGTTTCAGAAGCTTCTCCCTGACATCCGTGGAGCTGCAGATGCTGACCAACTCGTGTGTGAAACTCCAGACTGTCCACAGCATTCCGCTGACCATCAATAAGGAAGATGATGAGTCTCCGGGGCTCTATGGGTTTCTGAATGTCATCGTCCACTCAGCCACTGGATTTAAGCAGAGTTCAAATCTGTACTGCACCCTGGAGGTGGATTCCTTTGGGTATTTTGTGAATAAAGCAAAGACGCGCGTCTACAGGGACACAGCTGAGCCAAACTGGAACGAGGAATTTGAGATAGAGCTGGAGGGCTCCCAGACCCTGAGGATACTGTGCTATGAAAAGTGTTACAACAAGACGAAGATCCCCAAGGAGGACGGCGAGAGCACGGACAGACTCATGGGGAAGGGCCAGGTCCAGCTGGACCCGCAGGCCCTGCAGGACAGAGACTGGCAGCGCACCGTCATCGCCATGAATGGGATCGAAGTAAAGCTCTCGGTCAAGTTCAACAGCAGGGAGTTCAGCTTGAAGAGGATGCCGTCCCGAAAACAGACAGGGGTCTTCGGAGTCAAGATTGCTGTGGTCACCAAGAGAGAGAGGTCCAAGGTGCCCTACATCGTGCGCCAGTGCGTGGAGGAGATCGAGCGCCGAGGCATGGAGGAGGTGGGCATCTACCGCGTGTCCGGTGTGGCCACGGACATCCAGGCACTGAAGGCAGCCTTCGACGTCAATAACAAGGACGTGTCGGTGATGATGAGCGAGATGGACGTGAACGCCATCGCAGGCACGCTGAAGCTGTACTTCCGTGAGCTGCCCGAGCCCCTCTTCACTGACGAGTTCTACCCCAACTTCGCAGAGGGCATCGCTCTTTCAGACCCGGTTGCAAAGGAGAGCTGCATGCTCAACCTGCTGCTGTCCCTGCCGGAGGCCAACCTGCTCACCTTCCTTTTCCTTCTGGACCACCTGAAAAGGGTGGCAGAGAAGGAGGCAGTCAATAAGATGTCCCTGCACAACCTCGCCACGGTCTTTGGCCCCACGCTGCTCCGGCCCTCCGAGAAGGAGAGCAAGCTCCCTGCCAACCCCAGCCAGCCTATCACCATGACTGACAGCTGGTCCTTGGAGGTCATGTCCCAGGTCCAGGTGCTGCTGTACTTCCTGCAGCTGGAGGCCATCCCTGCCCCGGACAGCAAGAGACAGAGCATCCTGTTCTCCACCGAAGTCTAAAGGTCCCAGTCCATCTCCTGGAGGCGGACAGATGGCCTGGAAACCTCTGGCTAATCGGGCCATCCGTAGAGCGGGAACCTTCCTGAGGTGTCCTTGGGCCACCCCCAAGTGTTGGGCCATCTGCCAAGAGACAGCGACCCAAAGCCGAAGGACAGGTGGCCTGGAAAGATCCCGCCCAGGTCTGGGAGCCCCAGGCTGGCCTCAGACTGTGGTTTTTTATGTGGCCACCTGAGGGCGCCCCAAGCCAGTTCATCTCGGAGTCCAGGCCTGGCCCTGGGAGACAGGGTGAAGGGAGTGGTTTTTATGAACTTAACTTAGAGTCTAAAAGATTTCTACTGGATCACTTGTCAAGATGCGCCCTCTCTGGGGAGAAGGGAACGTGACTGGATTCCCTCACTGTTGTATCTTGAATAAACGCTGCTGCTTCATCCTGTGGGGGCCGTGGCCCTGTCCCTGTGTGGGTGGGGCCTCTTCCATTTCCCTGACTTAGAAACCACACTCCACTTCTAACAGGGTTTGAGAGGCTTAGTCAGCACTGGGTAGCGTTTTGACTCCATTCTTGGCTTTCTTTTTCTTTCCAGAAGGATTTTTGTGCAGAAATGGGTCTTTTGTTGCCATGTTAGTCCTCCTTGGAAGGCAGCTCAGAAGGCCTGTGAAATGTCAGGGGACAGGACCCCCAGGGAGGGAACCCCAGGCTACGCACTTTAGGGTTCGTTCTCCAGGGAGAGCGACCTCGTCCCCCGATCCTGACCGCCCTTCCGGCCCACGCTCTCCTGTTTGGCTTCCACAGGCCTGGACTTCTCTGGCTTCTCTGCCCACACACTCCCTGCCCCCAGTGTCCCTGCCCCTGCCCCAGCACAGGTGACTTCATTTCTGTCCTCTCAGCTCAGTGGACTCGCTCAACTTTTGTATAAGTCTCCACTTGGTGGCAGCAGCTTGCTGATGACTTGTTTTAAAACTTTCATCCTAAATAACCTTTTGATACTTGAATATTTGTAAGTTTTATACATAGTTTCTAATTTTTTTCCGAACAGATCCAGATACCTAATAAGATGCTGGAATGTAATCCCTGGACAATCCGTGTCCTGGCAGCATTTGGTCTTCCTCTAAGCGCCTGGCTCCGCTGTTCTCAGGAGTGGGTTCTGAAGTCTCTGGAGAACAGGATACGTGGAGGGTTAGGAAGGGGCCAGGCCTAGAGACGGGAGACTCCCTCCCGGAGCAGGTGGAGGCACAGGACCATTCGCTACCCCATCTGCCGACACCTGCGGGGGAGCCCAGGCATTCTTTGTAAACCCTCCTGACCACCTGGCTCAAAGAAAACAGAAGCATGGAGACCGCCAAGTATTTTCAAGAAATAACCCCATGAATATTCCATCACTTTTTTAGAAAGAGGGGCTTGGGGCAGGCAGAGGAGAGAAGGGAGAGCAAACTGAGAGCCAAGTTTCCACACGGTCCTGCAGGAGGAGAGGATGCAGCTGCCCAGAGGGAAGCAGGATCACATTTAAGGAAGTGTGTGGGGTCCCTGGATGACACCAGCACCCAGTGCGGCTCTGTCTGGCACCCGCTCCCAAGGTGGGAGGAGTGGGTGTCCCCTGTGTGTCAGTGGGCAGCTCCTGCTGAACCCGCAGCTCACTAGGGAGCCTGACAGTGGGGCCATGCGCCTGACACTCCTCTCTGCTTGTGGACCTGGCAAGGCAGGGAGCAGAAAACAGCCACTTGAAGGCTTTCTGTCTGCGTCTGTGTGCAGTGTGGATTTAGTTGTGCTTTTTTCTTGCTGGGAGAGCACAGCCACCATTTACAAGCAGTGTCACCGTCGTGGGTGGCGAGGACAGAACAGGAGCCTCTGCTCTCTGTACCTATCTGGGCCCGGTGGGCTCCCTTGTCCTGGCTTCCATCTCTGTCTCAGCGACCATTCAGCCCTGCGCAGGAACACGTGTTGCTTAGAAAAGCCAAATCCAGCCTTGTCTCTGCCTCCTCTGGTCTCATGATGTGCATCTGTTACCTTGAAACTGGAAACCAGTCTATCAATGTCTGTGCCAATTTTTTATTCCCTCCCCAACCTCCTTCCCCATACGACTTTTTATTTATGTAGGATGTGTGCTGTCTAATGATGGGATGACCACACTTTTCCATGTTCTAAAAGTGCTCCTCTCCCGCAGGGTCCCAGGGCTGGTGGTTGCTTTGGGTCTACAGCTACGTCTTACCCACCTCCTGCCTCAACAGCCTGTGTGGTGGCAAAGCCGGTGTGGGGCTGGGGAACGCAGCGTTCTCCAGGAGGGGGACCTGGCTCTCCTTCTGCAATGCAGGCGAAGGCCTAGATGCCAGTGTGACCTCCCACAAGGCGTGGCTTCCAGACTCCCCGGCCGGAAGTGATGCTTTTTTGCCTTGGGCCCTGGGTTTGAAGCAGCCTGGCTTTCTCTTGGTAAGTGGCTGGTGTCTTAGCAGCTGCAATCTGAGCTCAGCCACCTACACACCACCGTGGCCGACACTTTCATTAAAAAGTTTCCTGAGACGA