Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Gene Name SELENOK
Plot displaying the genomic locations of a parental gene (in chr22) and its retrocopy(ies). Each line represents a retrocopy.
Specie Bos taurus
Full Name N/A
Also known as SELK
Coordinate chr22:47024433-47031660
Strand +
Gene summary The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A pseudogene of this locus has been identified on chromosome 5. [provided by RefSeq, Aug 2017]

Retrocopy(s) from SELENOK

Retroname Coord Strand Genomic Region ENSG
SELENOKP1 chr5:101661117-101661630 - Intergenic
 ENSBTAG00000050124 UCSC

Expression

Transcript Sequences

>NM_001037489.3
ACCGTTTTGTCGATTCACGGCCTGTGATGTAAGAGGGAGGCGCGGAGGGAGATAAGGAATCCAAGAGGGGTCAGGCGTCGCCGTCGCCCTGAAGACGGAGGAGGGGCAAGATGGTTTACATCTCGAATGGACAAGTGTTGGACAGCAGGAGTCAGTCCCCATGGAGATTATCTTTTATAACAGATTTCTTCTGGGGAATAGCTGAGTTTGTGGTTTTGTTTTTCAGAACTCTGCTTCAACAAGATGTGAAAAAGAGAAGAGGCTACGGAAGCTCATCTGATTCCAGATATGATGACGGAAGAGGGCCACCAGGAAACCCCCCCAGAAGAAGAATGGGTCGAATTAATCATCTGCAGGGCCCTAATCCTCCTCCAATGGCCGGTGGATGAGGAAGGTAAATGTCTGCTCTAAGAAGCAGACAACTGGACGTGCACATTAATAGCAGAAGGAAACCATCAAGAAATGGAGTATGGATCATGCTGGACAAGTTAGATGAATGTGTACGTCTAAACAAGGATTGCTCTGTGTCCTCACAGACGAATGAGGTCATGCTGGGAATTCCCTCCGCAGGGATCTGGCATGACTGACATGCAGTTCTATAAATGCACGTTTGTCTCATCTTTTTTGTATCGTCTGTGAAAGTGTTAATATAGTTTTAATAAGTAAATATTTTTAGGTTACAAAGCTGACTTCTCATCTTTATAAAATTAAAACTCAAAAAGCTGCAAATTTGAAGGAAAATAAAAGACTGTATATTGATTACTATTAGTGTCACCTTTTTCAACTTATGAAATATTGTTCGTTGTTGGGTTTTTTGTTCTCATTTATAAATAAATCACTGTGCTTATTTCAGTAGTATGCA