Summary

Gene Name	Pfn1
Specie	Rattus norvegicus
Full Name	profilin 1
Also known as	-
Coordinate	chr10:57273003-57275708
Strand	-
Gene summary	Enables phosphatidylinositol-4,5-bisphosphate binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of nucleobase-containing compound metabolic process; positive regulation of stress fiber assembly; and positive regulation of viral transcription. Located in cytoplasm; neuron projection; and synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Pfn1

Retroname	Coord	Strand	Genomic Region	ENSG
Pfn1P1	chr2:60880138-60880463	+	Intergenic	N/A	UCSC
Pfn1P2	chr9:95800856-95801302	-	Intergenic	N/A	UCSC
Pfn1P3	chr16:20531917-20532232	-	Intergenic	N/A	UCSC

Expression

Transcript Sequences

>NM_022511.2

CAGCCGCGTTCCGGACGGCAGCGCGTGCCCCGAGCTCTCTGCCTTCCCCCGCCCGTCAGCCCGAGCCCAGCCCGCGATcccagcagcagcccgcagagcagccccagcagcagcGCCATGGCCGGGTGGAACGCCTACATCGACAGCCTTATGGCGGACGGGACCTGTCAGGACGCGGCCATCGTAGGCTACAAGGACTCGCCCTCCGTCTGGGCCGCTGTCCCCGGGAAGACCTTCGTTAGCATTACGCCAGCTGAGGTTGGTGTCCTGGTAGGCAAAGACCGGTCAAGTTTTTTCGTGAATGGGCTGACACTTGGGGGCCAGAAATGTTCTGTGATCCGGGACTCACTGCTGCAAGACGGGGAATTTACAATGGATCTTCGTACCAAGAGCACCGGGGGAGCCCCCACCTTCAATGTCACTGTCACCATGACTGCCAAGACGCTAGTCCTGCTGATGGGCAAAGAAGGTGTCCACGGTGGTTTGATCAACAAGAAATGTTATGAAATGGCCTCTCACCTGCGGCGTTCCCAGTACTGACCTCATCTGTCCCTTCCCCCACCGCTCCCTTTGGCTTTTGCACCCCCTTCTTTCCATACACACACACACCATTATTTTTTGGGCCATTACCCCATTTCCCTTATTGCTGCCAAAACCACATGGGCTGGGGGCTGGGGCTGGATGGACAGATACCTCCCCCTACCCATACCCCCTCCTGTGTGTGTTTGGGAAAAAATTGTTTTTGGGTTTCATTTTTGTTTTACTTTTTTTTTGTTTTGTTCTTTTTTTTTTTTCTGAATAAAAAAAGATTCTACTAA