Summary

Gene Name	BRAF
Specie	Homo sapiens
Full Name	B-Raf proto-oncogene, serine/threonine kinase
Also known as	B-RAF1|B-raf|BRAF-1|BRAF1|NS7|RAFB1
Coordinate	chr7:140713328-140924929
Strand	-
Gene summary	This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Retrocopy(s) from BRAF

Retroname	Coord	Strand	Genomic Region	ENSG
BRAFP1	chrX:75582653-75586517	+	Intergenic	ENSG00000224775	UCSC

Expression

Transcript Sequences

>NM_004333.6

CTTCCCCCAATCCCCTCAGGCTCGGCTGCGCCCGGGGCCGCGGGCCGGTACCTGAGGTGGCCCAGGCGCCCTCCGCCCGCGGCGCCGCCCGGGCCGCTCCTCCCCGCGCCCCCCGCGCCCCCCGCTcctccgcctccgcctccgcctccgcctcccccagctctccgcctccCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaacggggacatggagcccgaggccggcgccggcgccggcgccgCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGACAAATTTGGTGGGGAGCATAATCCACCATCAATATATCTGGAGGCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATTGGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGTGCTACCTTCATCTCTTTCAGTTTTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTTCCTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCTAATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGAAGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAAACGTTTTTCACCTTAGCATTTTGTGACTTTTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTGTGTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGGCGTCCTTAGCAGAGACTGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCATTCCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCATCAGCTCCCAATGTGCATATAAACACAATAGAACCTGTCAATATTGATGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGTGAACCAAAGAACACTTGTGTGGTTAAAGACTAGATATAATTTTTCCCCAAACTAAAATTTATACTTAACATTGGATTTTTAACATCCAAGGGTTAAAATACATAGACATTGCTAAAAATTGGCAGAGCCTCTTCTAGAGGCTTTACTTTCTGTTCCGGGTTTGTATCATTCACTTGGTTATTTTAAGTAGTAAACTTCAGTTTCTCATGCAACTTTTGTTGCCAGCTATCACATGTCCACTAGGGACTCCAGAAGAAGACCCTACCTATGCCTGTGTTTGCAGGTGAGAAGTTGGCAGTCGGTTAGCCTGGGTTAGATAAGGCAAACTGAACAGATCTAATTTAGGAAGTCAGTAGAATTTAATAATTCTATTATTATTCTTAATAATTTTTCTATAACTATTTCTTTTTATAACAATTTGGAAAATGTGGATGTCTTTTATTTCCTTGAAGCAATAAACTAAGTTTCTTTTTATAAATTTTGAGTGCAGGTGACCAAAAATATTGCTGAGGAGTGGCACGTTTGACATGAGTAAAATGTCTTAACTTCGGATTTTTAGCGGGAAAATGTTATAAATTGGAGTTTCTTTTAAATAGCTTTTTTTAAAATACATTAAGGATGTCTCGCTCATGTAGAAGTCAAATTTTGTTGCAAACGCATTGCTCCCTTCACACCCAATCTCTCCCCTGCAAAAAATCTTCACAGAATTCTGTGAGAACTTTTAGGTGTGTTTTTCTTTGAGATACCTCTGGTTGCCAAACACCAGGTAATAGATTTTTTAAAGTTGTTATTAGATTATTCTTACCTCTCATGATGCATATTTTAGCAATCACCTTATCATTGTGTCTCATGTTCTGTCCTCCTTATATTCTTTGCCCAGCAAGATTCTACTTATGATGAATGAATGCTCTTCTCCTTTTTTCATTCAATGGTATGAAGTATTTGTTAGGGTTCTTTAGTACTTACACTTTGTTGTGTAGAAAATGACTGTAATGTGGTGGTCAGTGTATTCTTACTGTGATTCAGAGGGAATCAAAAGTAGAAAGCAACAGCACGTGGTCCTATCAAAGATTTGGCCATCTCTGCTTCACTGTCAGCCTCTTAACTATATCTTCACTTACTCAATTTGGTTTTGTCATGATTTTTAAATGTAGCCAATAGATCAAGGTTCTTCCAGTAAACACATATCTGCATAAATGCCTCCTTGAAGTCAATAAAGAAGGAAATTGAGAAGACTTTAAATTAATGATAATTTAGTTTTTAAGTACCCACAAATAAATTTTTGAAACATTTTCTTTATTTGAATACTTAGATGTCATCCAGGAAAATCACTCAATAATAATTACGGCAAATCTTTAACCCCTCATTTGGGTAGCTTAAGATAAGTAATGCCATTATGAATCAGAATTGATTCATGACTTTAGTTAAGAAAATGAAAAGGAACATTTCACGTATTTTTAAAAATGATACTAAGGAATAAAGAAGTACAACTATTGGAAAATATCTAAGTATATGATTTTTAAATCCTCCAGTGGCATTAAATATATGATTATTAGTAATTGTTAGATAGGGTTTTATTCATTCACAAATAGAAGACTAGCAAGCATGTAACTAACAAAGTTTTTACAAAATTGACTTTGTGGAATGCTCCAAATGTTTGGCCATTTTGAGGCACAAGGTCAGGGGTCTCTTTATTGATAGAGCTCCTTCTATAATTTCCCAGCATACCTGCCTCACAGTTATCTTCCTTTCATTGTTCACTCTCTTTTTCTTCTCAATGCCATCCTGCCTAGGCTCCCATCATCTGCATCTGACACCTTTCCTTTCTTTCTTTACTAGTCTCCTTTGCGATGGGTGTGGCTAAGCTCTGTAGAGCCACTCAGAAACTCATTGTTCCATTCTGTAGCCAGTAAAACATGCCTCCAAAGTGTCACAGAGTAATTCTACTCTCTCTTTTAAATTAGGTCCACCGGAAATGTTAGTGAAAGGACATTAAAAATGTGACAGGTGACATGTTTAGCTAACATGGATCTGGAGAAATAGGAAGCAGTAGAATTAAATGTTTCCCTTTCAGGTTTAATTGTATTTGTTCTTGGGTTTTGTTTTATACTGAGTTTTAAATATATTCTCCAAATAAAAACATTATTTTTTCTAACCATATGTAGAGTTAATCTCTTTGACTAAGTAATTGAAACAAAAGAACATTTGTTCTTTTGTGACTGCTTTTTTCCTAAAACCTGAGCCCTCTTTTTTTTTTTTGAAATTAAAGTTGATTTCCtttttttttttttttttttttttttttttttttttttttttgagacagagtctcgctctgtcgcccaggctggagtgcagtggcgggatctcggctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccaagtagctgggactacaggcgcccgccactacgcccggctaattttttgtatttttagtagagacggggtttcaccgttttagccgggatggtctcgatctcctgacctcgtgatccgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgcccggccTTAAAAGTTGATTTCCTTCTTCAGTAAGGAAACCTTTTTATAAATTTGTTTTGCATTTTAAAAGTTTTACTAATCAATGATGAGGAAAAAGATTTGTCTTCTTGATTTTAAATAGTTTCAGGATCACAGGATGTAATCAGATGCTTCCAGTTTATTTATTTTCAGGTATTACACTAGCCatttaatcttttttatttatttatttTCTTCCTGCCCCTCGGATGGCATATACCAGCCATTTAGATACTAAACTCTAATAGTTAAACCAATAGTTAAAATTGTCCTCTCTAAAACATTGGCTATTTAATATACCAGCTTAAATGGCCTTTCTCTCAAGTGAGTCACTCTTAGTTTAAGAAAATTATGTGCCTTTTTAAAAAATATTATGAAATGGTACTTCATGACAGAAACATTTTATCAGTTATAGTCTTATTTGATTGAAAATTGTTGAGCATTTCTGTAAAACTTTTTACTTTACTAAATATTTCATCTTTCCTGTGACTGTTTTCTCAAAGAATTTAAAAGACTCGATGTGTCTATGCCAGAATGTTTCTCATCCTTTTGAAACTGCCTGggccaggcgtagtggctcacgctgtaatcccagcacttttggaggccaaggtgggcagatcgcgtgagcccaggagtttgagaccagcctggacaacatggcgaaacggtgtctctacagaaaaatttaaaaattagccaagcatagtggtgcacaactgtagccccagccactcgggaggctgacgtgggaggatcccttgaacctgggggcggaggctgctgtgagccttcatcatgccactgcactccagcctgggcaacaaagcaaaaccctgtctcaaaaaaagaaaagaaaaaaagaaaCTGCTTGAAAGTCATGACGAAGAATGTCAGGAGGGGACTTATTCTGGCTGCAGTTGACTTTCTCCTTAAATGTCAAGTAGTGATTGATTTGGATAAGAAGTAAACTGTTACTTTTCATAACATACTTTAAGGAATTTATCAAATTCTATGTATAATGCCCATTAAAATATACTCCATTCTGGAGTAAAGGGTAAGAGTAATATTTTTAAACTAGTTAATAAAGTCTTTAGCTTTCACATAAACCATGATATTTGAGGTGTCTAAAATCACAGGGTCTTTTTTTTTTTTTTCAGTCTTCCCAGTTGTTCTCTGCTCTATTCCTAAATAAAGTTAACTTGAAAATGCA