| Gene Name | Selenot |
|
| Specie | Mus musculus | |
| Full Name | selenoprotein T | |
| Also known as | 2810407C02Rik|5730408P04Rik|Selt | |
| Coordinate | chr3:58484057-58500965 | |
| Strand | + | |
| Gene summary | This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| SelenotP1 | chr8:19629908-19631065 | + |
Intergenic |
ENSMUSG00000081920 | UCSC |
| >NM_001040396.3 |
| GACCTTGGCGGAGCGCGCCTGCGCAGTGGGGAGCAGTTCGTGGCTAGGTTTTGGGCTGCAGTCTGGGTCTGAAGGCGGCCGGAGCGGCTGTCTCAATTACGATGAGgctcctgctgcttctgctggtgGCGGCGTCGGCGGTGGTCCGCAGCGAGGCCTCTGCCAACCTGGGCGGCGTGCCCAGCAAGAGATTAAAGATGCAGTACGCCACCGGGCCGCTGCTCAAGTTCCAGATTTGTGTATCCTGAGGGTACCGGCGGGTGTTTGAGGAGTACATGCGGGTTATCAGCCAGCGGTATCCAGACATCCGCATTGAAGGCGAGAATTATCTCCCTCAACCAATTTATAGaCACATAGCATCTTTCCTGTCAGTCTTCAAACTAGTATTAATAGGCTTAATAATTGTTGGCAAAGATCCTTTTGCTTTTTTCGGCATGCAAGCTCCTAGCATCTGGCAGTGGGGCCAAGAAAATAAGGTTTATGCATGTATGATGGTTTTCTTCCTGAGCAACATGATTGAGAACCAGTGTATGTCAACAGGTGCATTTGAGATAACTTTAAATGATGTGCCAGTGTGGTCTAAGCTGGAATCTGGACATCTTCCATCCATGCAACAACTTGTTCAAATTCTTGACAATGAAATGAAACTCAATGTGCATATGGATTCAATCCCACATCATCGATCATAGCCCTACCTATCAGCACCGAAAACTCTTTTACACTAAGGGATTTTGCAAGAGCAGCGTGACTGACATTATGAAGGCCTGTACTGAAGACAGCAAGCTGTTAGTACAGACCAGATGTTTCTTGGCAGGCTCGTTGTACCTCTTGGAAAACCTCAGTGCAAGACAGTTTTCCATGCTGGCCCATGCTGAATTCTGCACATACATGTAGTGCAGTGATCCTGTGTAGCTTCCCCAGCCCACTGGTCATAGTTTCTTCTTGACACAGCATTACTACTTGTAATTCTTTTCTTGGTCATGTGTGAGAAAGCACAGCATTGAGTTATAACTTGAGTTTTTTTCAACATGTGTGTTAAGTCGGTTGTGTTTTTAtatgaattttcattttttttttaaatagtcaaaCATCAGTTTTCTTGGGGCAACACCTGAAGTTCCCAAATAATTTTTAAGAGGTTCTCGGATAGCTCTAATTGGCCATGGTTAATACATAGTTTTGAAAACATTGCAGATTGTGAACAGTAAATTATACAGGATTATGGAGAGGAAATCCAATATCCAGAATactctactctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgagagagagagggggggggtggggtggggtgggggaagattaTCAAGAACAGCAAAACCAACTACTTTAAAAATCCTATTGTGTAGTTCAAATGTCTTGCCGTGACCAAtctaatgaattaattaatggGCCCTTTATACTAAACTAATTTAAACTGAGCAGATGTTAAGTTAAATGAAAGTTTACTGCTCAGTGCCTCTCTTAGCATTATTTTTAACAACCATCtgcctaagttttttgtttttgacttacAGATAATCTCATAAAGAACATACTTTAGATTCACACATAAGTAATGAGCTAATTTACTGTTTTTAGAACGGTTGAAACTCACCTCACTAAAGAAAAATTCAGCGAAACCTCTTTACAAAGTGTATTATGTAAACAGAGATCATTTGTCTAGTAATTGAATTATCTTAACATCATATATCAGAATTTTATTGTATTtgaaagacaaaattaaaaatatttttaatgttttcatattGTTCCAGAGTTCTAAAGAGAAATTTAGAGTTGATAAAGACAATAAGAATGATTTCTCAGAAATAGAGCATAATTTTGAATAGCAGTTACATAGCAGCTGTGGCAACAGAAAGGGATTAAGTGGAAGAGCCAAATGTAATCCTGGACTTGTGAGTGGAAGTTATGAGCTGAGGGAAGGAACTGCAATGGGAGACTTGATGTTGATGCCACCTGACTCTTAGATGTTGAGAGCAGCTTGACTACTGGACACACACTGAGTGCATTCAGGCAATGCCTCTTACAGCCTAAAGTGGAATCTACTGTGATCTTCAGATAGCAGGAAGATAGTCTAGTGATGGAATGTTACCCTTTTGACTAGTATCATAGCACTGCTAGCCTAGGTTCTTTTGGTAATAGACATTGTAATTTAAACGGAAagttccatatatatgtatatattgactAGATCTTAAAACCTTGCTAATATGGTTGCCTACCACTTCAGACTCCACATCTTGCAAAGTTTAACATCGGAGGGGCCTTTCTTCAAGTAATAGGCATTCCATTTGTGATGCAGTTAGCTTTATGGCACATAGACATTCATAATTTGAGCCATGGATGTTCATGTGTACTTGACAGGTCAAACTATGAAGGACAATGTCAAATCTAACTTTCTCCATGTATGCCTTAGGTTGAATTTGTTTCCAAGTTAATAGCTTTTACTGGCTTAGACATTCACACtcatctctgttttattttatgcttaGTCATATTTAAATCCAGAATTTAATAGTCTACTAGACAGATAAATGAGAtgcatgaatataaaaatatataagggaAAGGAGATGGTAAACTATTTATAACTTTATTATATTACTAACATTTCAAAGTTTATTAGTTGCTTATAAATTGTATAGTTACAAAATGTCTGTGCTCCATTAATCAGAAGATCGCAACGTATCAGCAGGCTGGCTAATTTTACTGGTGTTTTCAACACAGTTGCTATTGTGGAAGGTTTTTTGCATTAATTAAAAAGTTGGTAAAACCTGGCTTTTACCTCAGCGTGTCAGATGTAGAGAACACGTGCTCTCAGTGTGTGAGTGGCAGTGGCTGTGCACTCGCATTCGTGACAGCTGCTCAGCCTGAACAGCTGTGCAATGCGGTGAGCTCCAGTCATGGTTCATTCTTACTTCAGAGCTTTAGTAGTTTGGAAGTTTGACTGACTGGCACATTCTATCATTGTCATAACTTAAATAATTcagttaaaattttttaaaacatgatttgATATTtagggcttttcttttttaaaaaatgagaagcaaGTAAAGAATTGTAAAGATTTGGGACTTCTTTGTGGCATTGTGAAATAAATAAGCCAATGTGAAAGGAACCCTGCTTTGTGAAAATGATTCTGTCCTAGTGTActttatgtagcagatgtgttgAGGGGATTCTGCACTGTAAAGGCTGTCATCCAGTGAATGGTGTTTGCTTTCTCGGGCATCTTAAGCCAACCAGTTTGTTTAACACCTATTTCTGACTCTAAATCTTACCTGTTTTAGAACTTAAAGTTGTTTTCCTAAGCTTTATAATTTGCAGGTACAGTACTGAGCCATTGACAGTGTTGTGATTTATTCTTGTCTGGAACATAAAGGAATAACATACGTTGTCCCATCTTAAGTTTTCCTGAGAAATGTATGTATTAACACACCCAAATCTAAAGAGAAAACGACCACTTTTCTTGTCTTGACCAGCAAGTAATTaattctagaagaaaataaagatcaCTTGGTTTTTAA |