Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Gene Name TDG
Plot displaying the genomic locations of a parental gene (in chr12) and its retrocopy(ies). Each line represents a retrocopy.
Specie Homo sapiens
Full Name thymine DNA glycosylase
Also known as hTDG
Coordinate chr12:103965842-103988874
Strand +
Gene summary The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

Retrocopy(s) from TDG

Retroname Coord Strand Genomic Region ENSG
TDGP1 chr12:25803192-25806259 + Intergenic
 ENSG00000255725 UCSC

Expression

Transcript Sequences

>NM_003211.6
AGAAGCCTGGAGGAGGAGCTTGAGTCCAGCCACTGTCTGGGTACTGCCAGCCATCGGGCCCAGGTCTCTGGGGTTGTCTTACCGCAGTGAGTACCACGCGGTACTACAGAGACCGGCTGCCCGTGTGCCCGGCAGGTGGAGCCGCCCGCATCAGCGGCCTCGGGGAATGGAAGCGGAGAACGCGGGCAGCTATTCCCTTCAGCAAGCTCAAGCTTTTTATACGTTTCCATTTCAACAACTGATGGCTGAAGCTCCTAATATGGCAGTTGTGAATGAACAGCAAATGCCAGAAGAAGTTCCAGCCCCAGCTCCTGCTCAGGAACCAGTGCAAGAGGCTCCAAAAGGAAGAAAAAGAAAACCCAGAACAACAGAACCAAAACAACCAGTGGAACCCAAAAAACCTGTTGAGTCAAAAAAATCTGGCAAGTCTGCAAAATCAAAAGAAAAACAAGAAAAAATTACAGACACATTTAAAGTAAAAAGAAAAGTAGACCGTTTTAATGGTGTTTCAGAAGCTGAACTTCTGACCAAGACTCTCCCCGATATTTTGACCTTCAATCTGGACATTGTCATTATTGGCATAAACCCGGGACTAATGGCTGCTTACAAAGGGCATCATTACCCTGGACCTGGAAACCATTTTTGGAAGTGTTTGTTTATGTCAGGGCTCAGTGAGGTCCAGCTGAACCATATGGATGATCACACTCTACCAGGGAAGTATGGTATTGGATTTACCAACATGGTGGAAAGGACCACGCCCGGCAGCAAAGATCTCTCCAGTAAAGAATTTCGTGAAGGAGGACGTATTCTAGTACAGAAATTACAGAAATATCAGCCACGAATAGCAGTGTTTAATGGAAAATGTATTTATGAAATTTTTAGTAAAGAAGTTTTTGGAGTAAAGGTTAAGAACTTGGAATTTGGGCTTCAGCCCCATAAGATTCCAGACACAGAAACTCTCTGCTATGTTATGCCATCATCCAGTGCAAGATGTGCTCAGTTTCCTCGAGCCCAAGACAAAGTTCATTACTACATAAAACTGAAGGACTTAAGAGATCAGTTGAAAGGCATTGAACGAAATATGGACGTTCAAGAGGTGCAATATACATTTGACCTACAGCTTGCCCAAGAGGATGCAAAGAAGATGGCTGTTAAGGAAGAAAAATATGATCCAGGTTATGAGGCAGCATATGGTGGTGCTTACGGAGAAAATCCATGCAGCAGTGAACCTTGTGGCTTCTCTTCAAATGGGCTAATTGAGAGCGTGGAGTTAAGAGGAGAATCAGCTTTCAGTGGCATTCCTAATGGGCAGTGGATGACCCAGTCATTTACAGACCAAATTCCTTCCTTTAGTAATCACTGTGGAACACAAGAACAGGAAGAAGAAAGCCATGCTTAAGAATGGTGCTTCTCAGCTCTGCTTAAATGCTGCAGTTTTAATGCAGTTGTCAACAAGTAGAACCTCAGTTTGCTAACTGAAGTGTTTTATTAGTATTTTACTCTAGTGGTGTAATTGTAATGTAGAACAGTTGTGTGGTAGTGTGAACCGTATGAACCTAAGTAGTTTGGAAGAAAAAGTAGGGTTTTTGTATACTAGCTTTTGTATTTGAATTAATTATCATTCCAGCTTTTTATATACTATATTTCATTTATGAAGAAATTGATTTTCTTTTGGGAGTCACTTTTAATCTGTAATTTTAAAATACAAGTCTGAATATTTATAGTTGATTCTTAACTGCATAAACCTAGATATACCATTATCCCTTTTATACCTAAGAAGGGCATGCTAATAATTACCACTGTCAAAGAGGCAAAGGTGTTGATTTTTGTATATGAAGTTAAGCCTCAGTGGAGTCTCATTTGTTAGTTTTTAGTGGTAACTAAGGGTAAACTCAGGGTTCCCTGAGCTATATGCACACTCAGACCTCTTTGCTTTACCAGTGGTGTTTGTGAGTTGCTCAGTAGTAAAAACTGGCCCTTACCTGACAGAGCCCTGGCTTTGACCTGCTCAGCCCTGTGTGTTAATCCTCTAGTAGCCAATTAACTACTCTGGGGTGGCAGGTTCCAGAGAATGCAGTAGACCTTTTGCCACTCATCTGTGTTTTACTTGAGACATGTAAATATGATAGGGAAGGAACTGAATTTCTCCATTCATATTTATAACCATTCTAGTTTTATCTTCCTTGGCTTTAAGAGTGTGCCATGGAAAGTGATAAGAAATGAACTTCTAGGCTAAGCAAAAAGATGCTGGAGATATTTGATACTCTCATTTAAACTGGTGCTTTATGTACATGAGATGTACTAAAATAAGTAATATAGAATTTTTCTTGCTAGGTAAATCCAGTAAGCCAATAATTTTAAAGATTCTTTATCTGCATCATTGCTGTTTGTTACTATAAATTAAATGAACCTCATGGAAAGGTTGAGGTGTATACCTTTGTGATTTTCTAATGAGTTTTCCATGGTGCTACAAATAATCCAGACTACCAGGTCTGGTAGATATTAAAGCTGGGTACTAAGAAATGTTATTTGCATCCTCTCAGTTACTCCTGAATATTCTGATTTCATACGTACCCAGGGAGCATGCTGTTTTGTCAATCAATATAAAATATTTATGAGGTCTCCCCCACCCCCAGGAGGTTATATGATTGCTCTTCTCTTTATAATAAGAGAAACAAATTCTTATTGTGAATCTTAACATGCTTTTTAGCTGTGGCTATGATGGATTTTATTTTTTCCTAGGTCAAGCTGTGTAAAAGTCATTTATGTTATTTAAATGATGTACTGTACTGCTGTTTACATGGACGTTTTGTGCGGGTGCTTTGAAGTGCCTTGCATCAGGGATTAGGAGCAATTAAATTATTTTTTCACGGGACTGTGTAAAGCATGTAACTAGGTATTGCTTTGGTATATAACTATTGTAGCTTTACAAGAGATTGTTTTATTTGAATGGGGAAAATACCCTTTAAATTATGACGGACATCCACTAGAGATGGGTTTGAGGATTTTCCAAGCGTGTAATAATGATGTTTTTCCTAACATGACAGATGAGTAGTAAATGTTGATATATCCTATACATGACAGTGTGAGACTTTTTCATTAAATAATATTGAAAGATTTTAAAATTCATTTGAAAGTCTGATGGCTTTTACAATAAAAGATATTAAGAATTGTTATCCTTAA