Summary

Gene Name	Cyld
Specie	Mus musculus
Full Name	CYLD lysine 63 deubiquitinase
Also known as	2010013M14Rik|2900009M21Rik|C130039D01Rik|CDMT|CYLD1|EAC|mKIAA0849
Coordinate	chr8:89423506-89478574
Strand	+
Gene summary	This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Retrocopy(s) from Cyld

Retroname	Coord	Strand	Genomic Region	ENSG
CyldP1	chr1:108697863-108700511	+	Intergenic	ENSMUSG00000101097	UCSC

Expression

Transcript Sequences

>NM_001276279.1

AGTTCGGAGGCGGGGCAGGTGGGGGCGGGCCCAGGTAGCAGGTTCGGCTGCGCGGGGGCCCGCGCGCCTGAGTGAGCTCCTATGTCATGGATTCTGAACTGGCTTATAATATCTGGCATGGATTCCTTTTAGCAGAGCAGGCCTCAAATCCGATAGAGCATGGTTGCTTGATCCCATTGCAGCCCTGCCACTAGTGGCTCCTGGCACTTTGAATTGCTGTCTTTTTACAACATGGATGCCAGGTTGCTAAAATCTTGCTTTGGGACTTACAGCGAGTTCATTTTTTTGGATTTTATGACAGATTTACTAGTGGCTCCTTTTTGCCAGTCAATGTTCTGAAAGTTACTGTCACAATGAGTTCAGGCCTGTGGAGCCAAGAGAAAGTTACTTCACCCTACTGGGAAGAACGGATTTTTTATCTGCTTCTTCAAGAATGCAGTGTAACAGACAAACAAACTCAGAAGCTGCTGAAAGTACCCAAAGGGAGTATAGGACAGTACATCCAAGACCGTTCTGTGGGGCATTCAAGAGTTCCTTCCACAAAAGGCAAGAAAAATCAGATTGGATTAAAAATCTTGGAGCAACCGCATGCAGTTCTGTTTGTTGATGAAAAGGATGTtgtagaaataaatgaaaaattcacAGAGTTACTGTTGGCAATTACCAACTGTGAGGAGAGGCTCAGCCTATTTAGAAACAGACTCCGACTAAGTAAAGGCCTCCAGGTAGACGTGGGCAGTCCTGTGAAAGTACAGCTGCGATCTGGGGAAGAGAAATTTCCAGGAGTTGTACGCTTCAGAGGACCTTTATTAGCGGAGAGGACGGTGTCGGGGATTTTCTTTGGAGTAGAATTATTGGAAGAAGGTCGTGGTCAAGGTTTCACGGATGGGGTATATCAAGGGAAGcagcttttccagtgtgatgagGACTGTGGCGTGTTTGTTGCATTGGACAAACTAGAACTTATAGAAGATGATGACAATGGATTGGAAAGTGATTTTGCAGGCCCAGGAGATACAATGCAGGTTGAACCTCCCCCTTTGGAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGAAAGTACAGAATCTGGAACAGTAATATTCTGTGATGTTTTACCAGGAAAAGAGAGTCTAGGATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGGTTTGATGGAGTACAGCTCTGTAGTTTTGCAAGTGTTGAAAGTACAATTCTCCTGCACATCAATGACATCATCCCAGATAGCGTGACACAGGAAAGGAGGCCTCCCAAACTTGCCTTTATGTCAAGAGGTGTAGGTGACAAAGGTTCATCTAGTCATAATAAACCAAAGGTTACAGGATCTACCTCAGACCCTGGAAGTAGAAACAGATCTGAATTATTTTATACCTTAAATGGGTCATCTGTTGACTCACAACAATCCAAGTCCAAAAATCCATGGTACATTGATGAAGCATTTGGGGGCTATTTAAGTGAAGTAGTAGAAGAAAATACTCCACctaaaatggaaaaggaaggttTAGAGATAATGattggaaagaagaaaggcatcCAGGGCCATTACAATTCTTGTTACTTAGACTCAACTTTATTCTGctTATTTGCTTTTAGTTCTGCCCTGGACACTGTGTTACTTAGACCCAAAGAGAAGAATGATATAGAGTATTACAGTGAGACTCAGGAGCTACTGAGGACAGAGATAGTCAATCCTCTGAGAATatatggatatgtgtgtgccaCAAAGATTATGAAACTGAGGAAAATACTTGAAAAAGTTGAGGCTGCATCAGGTTTTACCTCTGAAGAAAAAGaTCCTGAAGAATTCTTAAATATCCTGTTTCATGATATTTTAAGGGTTGAACCATTGTTAAAAATAAGATCAGCAGGTCAAAAAGTTCAAGACTGTAACTTCTATCaaatttttatggaaaaaaatgagaaagttgGAGTACCCACAATTCAGCAGTTATTAGAATGGTCTTTTATCAACAGCAACCTGAAATTTGCAGAGgcACCATCATGCTTGATTATCCAGATGCCTCGGTTTGGAAAAGActttaaactatttaaaaaaatttttcctTCCCTGGAATTAAATATAACAGATTTACTTGAAGACACTCCCAGGCAGTGCCGCATCTGTGGAGGACTTGCGATGTACGAGTGCAGGGAGTGCTATGACGATCCGGACATCTCAGCTGGGAAGATCAAGCAGTTCTGTAAGACCTGCAGCACTCAGGTTCACCTTCATCCCAGGAGGTTGAATCATTCTTATCATCCAGTATCACTTCCCAAAGACTTGCCTGACTGGGACTGGAGACACGGCTGCATCCCCTGTCAGAAGATGGAGTTATTTGCTGTTCTCTGCATAGAAACGAGCCACTATGTTGCTTTTGTGAAGTATGGGAAGGATGACTCTGCCTGGCTTTTCTTTGACAGCATGGCGGATCGAGATGGTGGTCAGAATGGCTTCAACATTCCACAAGTGACGCCCTGCCCAGAAGTGGGAGAGTACTTGAAGATGTCTCTGGAGGACCTGCACTCTTTGGATTCCAGAAGGATTCAAGGCTGTGCGCGCAGACTTCTTTGcgatgcatacatgtgcatgtaccaGAGTCCAACCATGAGCCTGTACAAATAACCAGGTTATCCGCAGTGGGCAGAGACAGCACAAACCTTAGTGCTGTGTCTTCCTCCAGCTTGTGGTTCTGTCCGGCACCCATTGCCGGCAATGGGTGTCTCTTTTGATGATGGCCCTTCAGCAAAGGATTCCTGTGTTTCCAAACAAATTGCTTTTGTGTTCCTGAAGTATTTAATAAGAAGCATTTTGCACTCTAGGAAGTATGTTTGTGTTGATTTTTTAAGAAGTCTAAATGGATTTATTAATATCTGACACTTTAAGTTAACTGCATTGATGATACGATATTTTTGGAAGCATACAATTTTAATTGTGACGTCTAAAACCTCTTTTAGTCCATTgaggatgtaaataaatatttcttcttaTGGACCAGGGATATGAAATCATTTTCCTTTTGTAGCTAATGATTGCCTTGAGAAAGACATAATATGATTTTATTAAGAGTCTGCCTTTACTCCAATTGTTGAAGGTGTGCTGAGTTTAATTGTTAATTTTCCTATATAGTGCTGATTTCCTGCATGTCTGTACTTTGCTGAGTTTCTGTGTTCCTGCAGCAGTGGTCAGAACATGCTGAAATTCCTTTCATggtgttattttttatttgttctagTTTTGAGATAAATGAGTGACTCTGTCATAAAATGTCcatttttgatttgttcttgaagAATTAGGGTACAAAACAAGTATCGTAGTCATAGTAACAACTGTTACTGAACAGGTCTTCTGTAGGGGCTCCTAAGTATGAGACAACATGCAGTGGTTTCTGAAATGACTGAGCGATAAGtaaattatatattctttttttaaaagatttattttatttatatgagtacactgtagctgtcttcagacacaccagaagagggcatcagatcttattacagatggttgtgagccaccatgtggttgctgggaattgaactcaggacctttggaagggcagtcagtgctcttaactgctgagctatctctctagccccaaattatatattcttatacAGACCCACAGTCCAGAGAAAGTGAAGCTGGCTCAGAGTTAGCACCAACATTTCCCTGAAAAAATGTGTTAGGTGTTTAAAAATCTCAtcgtaaataaattattttatttttagtttaagtGAATTTCTCTTAATTTAAATAAGACTAATATTTTTGTTTGACTGAAGACCCTTGTACTCTCTGGTGTCAGTTTGGTGTCACTTGAAACAATGACAACCACGTCAGCATGTTACTGCAATGTCAGTGATGGtttcaaaggagaaaatggaTGTCATCTTAGGACtgcttgtgtgtgtatagacCGTGGTGGATGCTGTAGAGTGCTTGTTGTCTGAGTGTTGTTTTGTGGTATGGCTGTCTCTCTGAATAATGTCAACCTTACAGAAAGAGAAGGTGTTATATGTGTAACATATGGCTTTATAAAAGATTTAATGTCAAAAGAGTCTATAAATATTGCTGTTATTTTTAAAGGCACTTTACTCCTTGGTTTTATTATTCCATTTTGCTGGCGTGTATTAGCTTTATATAAATCACAACACACAAAACTCGTCCATCTTGTAATCTTTGTACTTTTGCAATGGAAAAGTGTGTATACTGTGCACAGACTTTTATATAGCTGAGTGCCTAGACTGGGTGGAGAGGCCATGAGTAGATAGCAGTAAAGTCCTCCAGCTATAGGCTAGCCTTGTCTTCATCATCCTGGGACAGGTGAGAACGGTGAGCACAGGTGAGTCTGAGCTTGCACACTGACCAGAATTCAGTCACCCTGTAATAAGTATGTATTTAATGAGTCTGTTAGTGTGGTAGTGTGATTTTGAAAGGTTTAACTAAGGAATGGTGAGGTCTTTGTTTATAGGCAAGCCTGGCTTAACAGTGAAGGGGAGGGGGCTGagggaaagctttttttttttttaatttcagaaatgGAAGCAAAATCCATGTGCAAAGAGACTAGCTACTTGGCTTTCAGAGCAGAGGACTCAAAGCTTGTTTGCAGTGGTTCTGAAGTTGGGGTGGCACTTTGTGAGTGAGGAGGACCATGTCCACAGGCAATCCCTAAGCAAGATCGTCTCGAAATTGCACTGTGTTCTTTAGCAGTAGTGGCTGGGTAGGGGCACACAGCGGAACACCCACTTGCAGTGGCTGGGGAGGCCTGAGAAGCACAGGCCAGCGGGAGCTCTCTCCCATGCCTTCTTGTCCCTCTGGACAGCCCCTCCTCATTCCTTGTCCCAGCAGAGCCTGGTTTGCCCCTGGGGCAATAGGGTTGGACTGTGTGGTGCAGATAGCCCTCGTGCCTGTGGATTACTTTAATTTTGTAATCTTAGGTTTTCTGTACGGTTTTCCCattgccttttaaaatattttgagtgtCCTTCTCCTTATcaagatggtagtgtagtaggATTGTTTTACTCACAACATGGTTTAGGAGCCATAGCTACAAATAGGAAATATAAGAATTCTATTTCTCTACTGTGAGGCaaatctgtatatatgtatggagaGTCAGGAGGATGAacaagggagaggaaaggggccCAGGCACATTTTTAATCCAAAAGCTACAAAGTGTCGAGCTCCTCAGGGCCAGCTTCACAGAGAGTCCAGCTCAGTTCACAAAGTATTTTCTAAGTTGGGGAAATGCATTGAGAAACAGAGCGAGATATCTGTGTAGTGCAGCTGTGGGTGGTTGCTATGCATTTTATCCTCAGAGTAGCCtggggtttttattttatgtttgccaAGTGCTTAGGTAAATGGCCGGGCTCCTCTTACCTCTGACTTCTGGAGCGTGTCCATTCTCTGGTTGACTGAATGTGGCATTTTCATAAATCTAGGAGCAGCAGCCCTCCCAACTGCAATTTAGTAAGCAGGTAGATAAGCTTGCATCTGTTTGCATCTTCCTGCACTGAGTTGGGAGTGCAAAACCCCGTACTTGGCCTGGTGAGTAACTGCCAACAAGTATTTATGGGTCATTTGCTAGGTGGCTAGCATACGGCACGGGGCTAATGAGACCTGGGGCCTGCTCTCATATAGCTTACTGCTCAGTTTCTATACCAGAGCATCCGTTGGTGCTTCTTAGCCTAGGCATGGGTGACAGGCATGTCTGGGGACCACTTTGGGAGACAACCTAGTGTAACCTTATTGCAAAGGACTAAGAGACAAAAATCCTGGGTTCTTTCTCCATCACTTGCTCTGTAGCTGAATGAACACCACCTCGATttcttgagtttcagtgtctTGTTCTGTCTGATGAAAGGGTTGGATATGTAGTTGGATAAGCGGTACAAATTGTTAGGGTTCCAGGCCATGCCTGATACATCTGAGTTTTTGCTGGAGGTAGGAAATTTCAACTCAGAAGCTCATCCACAGAAAACAGTGACCAGCAGCAGGTATGGAGCCATAAGGCTGGAAGGCTTCAAAGACCCCTTCTTCTGTTACTGTTATCCACGGCAGTTATTCTGTGTAGGTGTGAAGGAGTGGCTACTGACTCTGTGTGGATCAGCGTTTACATATGACCTGATGGGAGTGCATCTGGTATGTGTTCCTCCCCCCTGTATTGCTGGAGAGATTGGCAATCGTAGGTATACACGGAAGTGTCGGGATGTTCAGTGGCGCGCACTTGGATGTTTCTTTTCACTTTATTTCTATAGAAACAGGTTCCAGGAGCCAGAGAAGTAGGGGAAAAAATCCCTGAGCTCATCTCTCTCTACTACTTAATAATGCAAACATTTAAATTCTTGGGAAGATTTTCCCGCCCCACTCCCTACCCCCAGTCACAGGTCAGAATAGGATTTCCTTCTTAGAGAAGGTAGGTCATGGGGCCTgcgattaaaaaaacaaaaacataaaacaaacaaacaaacaaggtggcTTTCCTTGGTCTTTGTGATTCCAGCTCTTCACCAGTGAAGGAATTCTTTAGTTCCATAGTGCAGCCTGGGTGGGTGGAGAAGAGGCTGTTATAGTGGGAGCCAGTGAGCAAAGAGGgttggaggaggcagaggacaggGCTCAGGGAAGGCAAGCCTGTGGCTCTGGGCATTGGCCCTCTTGTCAAAGGTGTCAGAGCATGGCTTCCTGTGAGGGGCTTTCCCTTGCTCCTGTGTGAGAATCTGTGCGTTGTCTTACTGGATGGGGGACCTGGATGGAGATGTTAGGGGAGATAGCTTAGTCTTGTTCTAAACTCTAGACTTGCTAAAAAGGGTTCTCTTGAGTCCAAATGCAGTGCCAGAGGGTGAGAAGCAGAATTGGCCAGTAGTGAACAGTGGTATTGTGGGTGATAAGCCCTTTCTGGTGGCCTTAAATAGCAGTGCTAGTCCTTGAGTGCCACAGGGTCCCCTACCTCCGTCCTGGCAGTGCTGATGGGTTTGTTTCAGCATATTTTGGTTCTCATTCTCATTTAGGGAAAAGGGCTGTTGATGAAGGGATTATCCTCCCAGGCACCAGGGGCCTCAGCACAGTTCCCTGTGCTTTTAAACACTGTTGACTTTCATTAGTTATTCTAAAGGGATTTATATTGGAGATACAACTCCCTTTGGTTTCATATTATGAAATAGCTTTGTACTGTGGAATGCTAACTCTGGAAAGTCTCCCTCATACCAGAACCaaacattcatttcttttatatatatatatatattatctccCTGGTACTCTCCAGGGAGGTGGTTATTATCAAGCTGACCCAAAGGAGTGCAGTATGTGTTCTAGTTCCTTTTCTGGTACCTTGTTCAACATTCTTTTTTCCTGAAGAACATCCTTTTGTTTATGAAAACGTGAATAGCATCATGTAAAACAATCCCTTGCTATCAGAATGCTCCAGTTTGGCCTTAATTTTGTAAACCTTGGAGAGGAGTGGAGCGCGGCTGTGAGAAGAGATGTACCATGTACTCTTTCTGTATCATTAAAGTGCAGTTTTTATGCTTCT