Summary

Gene Name	Selenok
Specie	Mus musculus
Full Name	selenoprotein K
Also known as	1110001C03Rik|HSPC030|Hsp30|Selk
Coordinate	chr14:29690337-29697031
Strand	+
Gene summary	The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Sep 2017]

Retrocopy(s) from Selenok

Retroname	Coord	Strand	Genomic Region	ENSG
SelenokP4	chr13:61947630-61948357	+	Intergenic	ENSMUSG00000095905	UCSC
SelenokP1	chr2:166935596-166935896	+	Intergenic	ENSMUSG00000083436	UCSC
SelenokP2	chr5:145559531-145560250	-	Intergenic	ENSMUSG00000105474	UCSC
SelenokP3	chr11:23508089-23508809	-	Intergenic	ENSMUSG00000085415	UCSC
SelenokP5	chr19:15436329-15437036	-	Intergenic	N/A	UCSC

Expression

Transcript Sequences

>NM_019979.2

ATGGGCTCGACCCACCTCTAGCCTGACTTGGGTCTGTCAGTGGCCTGTGACGTACAGGGCGGGGCGGGAGGCTAGGTACGGCGACAACAGGGGCGTCCGGTCTTCTCTGTCGCTAGGAAGCAGGCAACCGGAGGGAAGATGGTTTACATCTCGAATGGTCAGGTGTTGGACAGCAGGAATCAGTCCCCATGGAGAGTGTCTTTCCTAACAGACTTCTTCTGGGGAATAGCAGAATTCGTGGTTTTCTTTTTCAAAACTCTGCTTCAGCAAGATGTGAAGAAAAGAAGAGGCTACGGGAGCTCCTCTGATTCCAGATACGACGATGGAAGAGGGCCACCAGGAAACCCTCCACGAAGAATGGGTAGGATCAGTCACCTTCGTGGCCCCAGCCCTCCTCCAATGGCTGGTGGATGAGGAAGGTAAATGTCTGCTCTGAGAAGCAGACAACTAGACATACACACGTGTAGAAGGAAGCCATCAAGCGGTGAAGAGCGGCTCGTGCAGGAGAAGATGGTGTATGTCCAAACAAGGATTGCTCTGTGTCCCCACAGATGAATGAGGTCATGCTGGGAATTCCCTCTGCAGGATCTAGCCTGACTGATACGCAGTTCTATAAATGTACATGTttgtctccttatcttttttttgtatagtttacTAAAGTATTAATATAGTTTTAAGAAGTAAATATTTCTAGGTTGCAAAACTTAATTGTTCGTCTTTATATGATCATACCCAAAATCTTTGATCCGGAAGAAATAAAGGCCATGTATTTAGTCCTggagttttgtttggttggttttgtttgattggttttgtttttgtctggctTTTCCAAGCCATCACCCCCTTCTCCAGTGTATATAGTTCTGTTAATTTTGCCTTTTCTCAGCTTTTGAAATACTGCTCACTGTTACTTTGCTCTCATttataaataaaccaaaacataATTATTTCAGTAGTACATGTAAATTTGcttttgaatttttaatctttaatatACTTACTTTGTAAATGC