| Gene Name | CDK2AP1 |
|
| Specie | Homo sapiens | |
| Full Name | cyclin dependent kinase 2 associated protein 1 | |
| Also known as | DOC1|DORC1|ST19|doc-1|p12DOC-1 | |
| Coordinate | chr12:123260976-123271856 | |
| Strand | - | |
| Gene summary | The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| CDK2AP1P2 | chr3:120484074-120484422 | - |
Intergenic |
ENSG00000240774 | UCSC |
| CDK2AP1P1 | chr2:7324007-7325074 | - |
Intergenic |
ENSG00000213774 | UCSC |
| >NM_001270433.2 |
| ACTTGTGGGCTCGGAGTCCCAAAGAGCAAACAGCCACtgtttttttctcaaacattctcacctcctctggggtccgcagaccttacaaagacgggctttgttgccagCTGGGAGTGTCCACTCGCCTTCCACCAGCATGGCAACGTCTTCACAGTACCGCCAGCTGCTCAGTGACTACGGGCCACCGTCCCTAGGCTACACCCAGGGAACTGGGAACAGCCAGGTGCCCCAAAGCAAATACGCGGAGCTGCTGGCCATCATTGAAGAGCTGGGGAAGGAGATCAGACCCACGTACGCAGGGAGCAAGAGTGCCATGGAGAGGCTGAAGCGCGGCATCATTCACGCTAGAGGACTGGTTCGGGAGTGCTTGGCAGAAACGGAACGGAATGCCAGATCCTAGCTGCCTTGTTGGTTTTGAAGGATTTCCATCTTTTTACAAGATGAGAAGTTACAGTTCATCTCCCCTGTTCAGATGAAACCCTTGTTTTCAAAATGGTTACAGTTTCGTTTTTCCTCCCATGGTTCACTTGGCTCTGAACCTACAGTCTCAAAGATTGAGAAAAGATTTTGCAGTTAATTAGGATTTGCATTTTAAGTAGTTAGGAACTGCCCAGGTTTTTTTTGTTTTTTAAGCATTGATTTAAAAGATGCACGGAAAGTTATCTTACAGCAAACTGTAGTTTGCCTCCAAGACACCATTGTCTCCCTTTAATCTTCTCTTTTGTATACATTTGTTACCCATGGTGTTCTTTGTTCCTTTTCATAAGCTAATACCACTGTAGGGATTTTGTTTTGAACGCATATTGACAGCACGCTTTACTTAGTAGCCGGTTCCCATTTGCCATACAATGTAGGTTCTGCTTAATGTAACTTCTTTTTTGCTTAAGCATTTGCATGACTATTAGTGCTTCAAAGTCAATTTTTAAAAATGCACAAGTTATAAATACAGAAGAAAGAGCAACCCACCAAACCTAACAAGGACCCCCGAACACTTTCATACTAAGACTGTAAGTAGATCTCAGTTCTGCGTTTATTGTAAGTTGATAAAAACATCTGGAAGAAAATGACTAAAACTGTTTGCATCTTTGTATGTATTTATTACTTGATGTAATAAAGCTTATTTTCATTAACAATTTGTATTAAAATGTGGGTTCCTTGAA |
| >NM_004642.4 |
| AAAGTTTGCGGCCGCCCCTGCGCCGCACCCGGGGCCTGGGTGAGACTGCGGCGGCGGCAGGGCGCGGACGGCCATATTTGCCGGCGCGGCCCGAGCCGCCGACAACAAAAAGTGCgcgggcgctcggcgggcgctcggacgggcgcGGGGCTGCAGCGCTAccgcccggcctcgccgccgccgccgccgccctcgcggcctggccccgccgcgcccggcgcgcccgccgccCGGGGGGATGTCTTACAAACCGAACTTGGCCGCGCACATGCCCGCCGCCGCCCTCAACGCCGCTGGGAGTGTCCACTCGCCTTCCACCAGCATGGCAACGTCTTCACAGTACCGCCAGCTGCTCAGTGACTACGGGCCACCGTCCCTAGGCTACACCCAGGGAACTGGGAACAGCCAGGTGCCCCAAAGCAAATACGCGGAGCTGCTGGCCATCATTGAAGAGCTGGGGAAGGAGATCAGACCCACGTACGCAGGGAGCAAGAGTGCCATGGAGAGGCTGAAGCGCGGCATCATTCACGCTAGAGGACTGGTTCGGGAGTGCTTGGCAGAAACGGAACGGAATGCCAGATCCTAGCTGCCTTGTTGGTTTTGAAGGATTTCCATCTTTTTACAAGATGAGAAGTTACAGTTCATCTCCCCTGTTCAGATGAAACCCTTGTTTTCAAAATGGTTACAGTTTCGTTTTTCCTCCCATGGTTCACTTGGCTCTGAACCTACAGTCTCAAAGATTGAGAAAAGATTTTGCAGTTAATTAGGATTTGCATTTTAAGTAGTTAGGAACTGCCCAGGTTTTTTTTGTTTTTTAAGCATTGATTTAAAAGATGCACGGAAAGTTATCTTACAGCAAACTGTAGTTTGCCTCCAAGACACCATTGTCTCCCTTTAATCTTCTCTTTTGTATACATTTGTTACCCATGGTGTTCTTTGTTCCTTTTCATAAGCTAATACCACTGTAGGGATTTTGTTTTGAACGCATATTGACAGCACGCTTTACTTAGTAGCCGGTTCCCATTTGCCATACAATGTAGGTTCTGCTTAATGTAACTTCTTTTTTGCTTAAGCATTTGCATGACTATTAGTGCTTCAAAGTCAATTTTTAAAAATGCACAAGTTATAAATACAGAAGAAAGAGCAACCCACCAAACCTAACAAGGACCCCCGAACACTTTCATACTAAGACTGTAAGTAGATCTCAGTTCTGCGTTTATTGTAAGTTGATAAAAACATCTGGAAGAAAATGACTAAAACTGTTTGCATCTTTGTATGTATTTATTACTTGATGTAATAAAGCTTATTTTCATTAACAATTTGTATTAAAATGTGGGTTCCTTGAA |