Summary

Gene Name	ABI1
Specie	Homo sapiens
Full Name	abl interactor 1
Also known as	ABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1
Coordinate	chr10:26746596-26860986
Strand	-
Gene summary	This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Retrocopy(s) from ABI1

Retroname	Coord	Strand	Genomic Region	ENSG
ABI1P1	chr14:55546578-55550298	+	Intergenic	ENSG00000271484	UCSC

Expression

Transcript Sequences

>NM_001178124.2

GGTTTGTATCCGGGCTGTGAGGTGCTCGGAGCCTCGGCGGACCTTGCTGCCTCTGTCTCTTTAACGCGAGAGGAAGCGATGCAGAGGGGTGGAAAATGGCAGAGCTGCAGATGTTACTAGAGGAGGAGATCCCGTCTGGCAAGAGGGCGCTGATCGAGAGTTACCAGAACCTGACTCGGGTGGCAGACTACTGTGAAAACAACTACATACAGGCTACAGACAAGAGAAAAGCTTTAGAGGAGACCAAAGCCTATACAACCCAATCTCTAGCTAGTGTTGCTTATCAAATAAATGCATTGGCCAACAATGTACTCCAGTTGCTGGATATCCAAGCCTCTCAGCTTCGGAGAATGGAGTCTTCCATCAATCATATCTCACAGACTGTGGATATTCATAAGGAGAAAGTGGCACGAAGAGAGATTGGTATTTTGACAACAAATAAGAATACATCAAGAACTCACAAAATAATAGCACCTGCGAATATGGAGCGCCCTGTAAGGTATATTCGGAAACCTATCGATTACACAGTTCTGGATGATGTGGGCCATGGTGTCAAGCATGGAAATAACCAGCCTGCAAGAACTGGCACACTGTCGAGAACAAATCCTCCTACTCAGAAACCGCCAAGTCCTCCCATGTCAGGCCGGGGAACACTGGGACGGAATACTCCTTATAAAACCCTGGAACCTGTTAAACCCCCAACAGTTCCTAATGACTATATGACCAGTCCTGCTAGGCTTGGAAGTCAGCATAGTCCAGGCAGGACAGCATCTTTAAATCAGAGACCAAGGACACACAGTGGAAGTAGTGGAGGAAGTGGAAGTCGAGAAAACAGTGGTAGCAGTAGTATTGGCATTCCCATTGCTGTGCCTACACCTTCGCCACCCACTATTGGACCAGTTGCTGATAGTCCAACTCCACCGCCACCACCTCCACCAGATGACATTCCCATGTTTGATGACTCTccacctcccccaccaccaccaccaGTGGATTATGAAGATGAGGAGGCTGCAGTAGTTCAGTATAATGATCCATATGCAGATGGGGATCCTGCTTGGGCCCCCAAGAATTATATTGAGAAAGTTGTTGCAATATATGATTATACAAAAGACAAGGATGATGAGCTGTCATTTATGGAGGGTGCAATCATTTATGTTATAAAGAAGAATGATGATGGCTGGTATGAAGGAGTCTGCAATCGAGTGACTGGTCTGTTCCCTGGGAACTATGTTGAATCAATCATGCACTATACTGATTAATTTTTTTTTTTCTTTTGAAGTAGATTCTTATTACTCAGTCATACTGTGGGACTATTATGGTTAACAGAACTGTCTTAATATGTTTTAAAATGTGCCCATATTTTCAGAACATGCTGTTTTATTGGTAAATTGAATGTCTACCTGTAAGCATAAATCTTTGAGGCAGTTTATGTATTGCTGAATAGCAATTTATACAAGAAGCTGTCCATAACTGATTATGCTTATGTACTTACTTACACATTTTTAACTTTATGACCAGCCTAAATATTCTGGGGGAAGTGGGGTATAATATTTAACGAATCATGATTCAGATTGTACCATTACATGTTTCAGTGCAGCATGGTTACTAACGCTATGTCAGACTAATATTAAAATCAGAAAATTTAAATGCTGGTGCTGGTCAGACTTTTTTTGTTAGATTCTCTCATTTAAAAAAAATACTGTTTGTTTAAAGCATGCATAAAAATTTATGTATTGAAATATACTTAAAAATTCAAGATGCTTCCCATTTGTGTAATATTTACCTGGAGGACTCGTACTTAGGTGTCTTAACGTGAATTGAGTCTCCAAGGTCTCCATGTGAAACAAGCAAAAAGAGAATTATCTGTAATGTTGTAATTTGTACCTAAGTTTTTTAATGAGTGAAATTTGCATTATAAACTTTTTCCATTCATAAATACATAAGTGAACCAAAGGTTTTTGTCCTTTCCTTCACTGATTTGCTTTAAAAAAAATAAAAGATAATGATTTATTGCAGAATTATGATTCTATTTTCTCAATATGTTAACTTGGAAAAAAATTTTAGCCTTATCTTAATCTGTCCCAACAGCAATGTGACGGATTTTTGCAGATTCAAAATCTGCAATGGTTATTTACAAGTCAATCTACTGAATTCCTTTTTTAAATAATCTTTTGAAACTAAGAAAATGTGTCAAATTGTGTGCATTCATTCTGTAGGTAAAATTCTTAAGGATTGCCATGTCAGTCCTTCAGTTGTACAGTGAACTGTTGTACACTGGTTCAATGAAAGGAAGTTAAAAGTACCTTTTACATATTGTAAAAGTGGATACAGTTGATTTGTGAGTAGGCACTCTTTAATCCATTACCTGGCACTAGCAACATTAGAATTTTAAAATAAAATAATTGGGAAAGAAGGTGGGTCATGTATTAATCAGTGAACAGAGATTTACCTAACCAACAGACTTGGATTGTCTTTTGACATAATCAAAATGCAACACATGCACTTTGTGTGTCTCCTCTTAATTGAAGGGAGGGCTGAGGGATGTTTTCTCTTCTTGTCTTGTGTATAATTCTCTATTGCTTAGGATATTAAAGTAGAGCACTCAAGTGTGGGTTTCTGTGTTATTGAGGATTTGTTTGGAATTCAAATTACAGTTATGTACTGGATGCTACAGACTTATAACAGCATAGTGAATGGTAAGACTAGTGCAAAACAGTTATTTCTGAAAATTAAAGACCATTATTGCTACCAAATCAATGTGACTATTTCATATGCATTTTGCCTTTGTTAATTTTAAACAAACAAAGTATCATTAGTGATCAGCTAGCTACCTTCTACTTTCCATTTTTCAAGTGGATTGTTCTCTTAATTTGTATATAACCTGTTGTCTAAATTTTATGTACAGTCTTTTATAATAAACCATTCTCCTATATGAAATTTTGGATACTGTTAAAATATAACTCATGTGGACTTCAATGCAGACTTCACATTTTTCTGACCTTTACTCCTACGGTAAATCAAGACAAACCATTTGAATTTTAACATTGGTTATTTATTTGTGTAATGGCCTTACATGTGGATATTAACAGTGTAAACAATACCACATATAACCATCAAGATACCTTGATTATAATTTATAGGACTAGAATGACAGATTCAGGTGGTTTATTAATTACATTTAAAAAGTTTTCTGAAAAAACTTTTGCAATAAAAAAAAATAAATTGCCCATCAA