Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ABI1P1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:55546578-55550298  UCSC
Coordinates (T2T) chr14:49752279-49756000  UCSC
Coordinates (hg19) chr14:56013296-56017016  UCSC
Strand +
Parental Sequence NM_001178124.2
Parental seq. overlap 2676 bp
Parental seq. overlap (%) 81.3%
Genomic Region Intergenic
Retrocopy Summary ABI1P1, located on chr14:55546578-55550298, is a retrocopy of the parental gene ABI1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ABI1
Full Name abl interactor 1
Also known as ABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1
Coordinate chr10:26746596-26860986
Strand -
Gene summary This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ABI1P1
Bonobo Pan paniscus ABI1P1
Gorilla Gorilla gorilla ABI1P1
Orangutan Pongo abelii ABI1P1
Gibbon Nomascus leucogenys ABI1P1
Green monkey Chlorocebus sabaeus ABI1P1
Crab-eating macaque Macaca fascicularis ABI1P1
Rhesus Macaca mulatta ABI1P1
Baboon Papio anubis ABI1P1
Golden snub-nosed monkey Rhinopithecus roxellana ABI1P1
Marmoset Callithrix jacchus ABI1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ABI1P1
TGGTTTGGATCCAGGCTATGAGGTGCTGGGAGCCTCAGTAGAACTTTCTGCCTCTGTTTCTTTAATGCAAGAGGAACCGATACAGAAGGGTGGAAAATGGCAGAGCTGCAGATGTTACTAGAGGAGATCCTGTCTCACAAGAGGGCACTGATAGAGAGTTACCAGAACCTGAACCAGGTGGCGAACTACTGTGAAGACAAGAGAAAAGCTTTAGAAGAGACCAAAGCCTACATAACCGGACCTCCAGTTAGTGTCACTTATCAAAAAACTACAGTGTCTAACAATGTACTCCAGTTGGTGAACATCCAAGCCTTTCAACTTTGAAGAATGGAGTCTTTCATCAATCATATCTCACAGATCATGGATATTAATAAAGAGAAAGTAGCTCGAAGAGATATTGGTATTTGGACAACAAATAAGACTACATCAAGAATTCACAAAATAATAGCGCCTGCAAATATGGAGCGTCTTATAAGGTATGTTTGGATACCTATTGCCTACACAGTTCTGAATGATGTGAACCATGGTGCCAAGCATGTAAATAACCAGCCTGCAAGAATTGGCACACTGCCATTGGCACACTGCCAAGAACAAGAGCAAATCCTTCTTTCCAAAACCACCAAGTCCTCTCGTATGAGGCCAGGGATTACTGGGACAGAATACTCCTTATAAAACCCTGGAACCCATTAAACCCCAACTGTTCCTAATGACTATATGATGCATCCTGCTAGGTTTGGAAGTCATCATAGTCCAGGCAGGTCAGCTTCATTAAATCAGAAACCAAGGCAGACAATGAAAGTAGTGGAGGAAGGGAAGTCAAGAAAACAGAGGAAGCAGTAGTGTTAGTATTCACATAGCTGTACCTATACCTTCACCCCCTATTATTGGATAGTTTAACTCCTCCACCACCGACACCACCAGATAATGTTCTCATGTTTGATGACTTTCCACCTCCACCATCACCCACTCCAGTGGATTATGAAGACGAGGAGGCTGCAATAGTTCAGTATAATGTTTCATATGCAGATAAGGATACTGCAAGGTCCCCAAAGAATTATATTGAGAACATCATTGCAGTGTATGATTATACAAAAGACAAGGATGATGAGCTGTCATTTATGGAGGGTGCAGTCATTTATGTTATAAAGAATGTTAATGGCTTATATGAAGGAGTCTTCAATCAGGTGACTGGTCTGTTCCCTGGGAGCTGTGTTGAATCAATCATTCACTATGCCGATTAATTTTTTTTTTTGCTTTTAAAGTAGATTCTTGTTATTACTCAGTCATACTGTGGGACTGTTGTGGTTAACAGAATCATCTTAGTATGTTTTAAAATGTGCTCATATTTTCAGGACATGCTATTTTATTGATATAATTGAATGTCTACCCATAAGCATAAATCTTTGAAGCAGTTTGTGTATTGCTAAACAGCAATTTATACAAGAGGCTGTCCATAACTGATGATGCTTATGTACTTACTTACACATTTCTAACTTTATGACCAGCCTAAATGTTCTGGGGAAGTAGGGTGTAATATTTAACAAATCATGGTTCAGATTGTACATGTTTAGGGCCGCTTGGTTACTAATGAATGCTGTGTCAGACTACTTAAATGCTAAAGTCAGAAAACTTAAATGCTAGTGCTCATCATACTTTCTGTTTAGATTCTCTTATTTTAAAAAATACTGTTTGTTTAAAGCATGCATAAAAATATATGTTTTGGAATATACTTAAAAGTTCCAAGATGCTTCCAGTTTGTGTAATATTTCCCTGGAGGACTCATACTTAGGTATCTTAAAATGAGTTGAATCTCCAAGGTCTTCATGAAACAAAAGAAGCAAATGGAGGGTTATCTGTAGTGCTGTAATTTGTACCTAAGTTTTTTAAGGAGTGGGATTTACATTATAATTTTTTTCCACTCATAAATATATAACTGAACCAAAGGTTTTTGTTTTTCTTTCACTGATTTGCTTTAAAAAAATAAACGATAGTGACTTATTGTAGAAGTACAGTTCTATTTTCTCAATATATTAACTTGGAAAAAATTGTAGCCTTATCTCAATTTGTCCCAACAACAATGTGATGAATTTTTATAGATTCAAAATCTGAGATGACTATTTAGAAGTTAATCTACTGAATTCCATTTTTAAATAACCAcTTAAATAAACTTTTAAAGCTAAGAGAATTTGCCAAAGTGTGCACAATCATTTTGTAGGTAAAATTCTTGAAGATTGTCACATCATTCCTTCAGTTTTACAGTGGACTGTGGTATACCAATTCAACAAAAGGTAATTATAAGGGTCTTTTACATATTGTAAAACTGGATGTAATTGACTTGTGAATAGGCACTATTTATTCCATTTCCTGACGCTAACAACATTAAGGTTTTAAAATAAAATAATTGGGAAAGAAGGTAGATCAGGTATTATTCTGTGAACAGAGATATACCTAACCAACAGATTTGTATTGTCCTTTGACATAATTGAAATGTAACACATGTACTTTGTGTGTCTTCTCTTAATTTAAGGCAGGGCTAAAGGAGTGTTTTCTCTTGTTATCGTGTATGTAATTCTATATTGCTTAGGATATTAAAGTAGAACACTCAAGTGTGAGTTTTGGTGTATTGAGGATTTGTTTGGATTTCAAATTATGGTTGTATACTGGATGTTACAGACTTATAACAGCATAATGAACGGTAAGACTAGTGCAAAACATTTATTTTTGAAAATTAAAGGCCATTATTGCTGCCAAATCAATGTGATTGTTTTAACTTTAAACAAAGTGTCATTAGTGATCAGTTAGCTGTCTTCTGCTTTTCATTTTTCAAGTGGATTGTTCTCTTAATTTATATACAAACTTTTTGTCTAAATTTTACATAGTCTTTTTTAATAAACCATTCTCCTGTATGAAATTTGGGATAGTGTTAAAATACAACTAATGTGGACTTAAATGCAGACTTCACAATTTTCTAATCTTCACCCTGTGGTGAAATAACACAAACCATTTGAATTTTAACATTAATTATTTATTTGTGTAATGGCTTTACATGTGAATATTAGTAGTGTAAACATACCACATATAACCACCAAGATATCTTAATTAGAATTTATAGGACTAGAATGA
>NM_001178124.2
GGTTTGTATCCGGGCTGTGAGGTGCTCGGAGCCTCGGCGGACCTTGCTGCCTCTGTCTCTTTAACGCGAGAGGAAGCGATGCAGAGGGGTGGAAAATGGCAGAGCTGCAGATGTTACTAGAGGAGGAGATCCCGTCTGGCAAGAGGGCGCTGATCGAGAGTTACCAGAACCTGACTCGGGTGGCAGACTACTGTGAAAACAACTACATACAGGCTACAGACAAGAGAAAAGCTTTAGAGGAGACCAAAGCCTATACAACCCAATCTCTAGCTAGTGTTGCTTATCAAATAAATGCATTGGCCAACAATGTACTCCAGTTGCTGGATATCCAAGCCTCTCAGCTTCGGAGAATGGAGTCTTCCATCAATCATATCTCACAGACTGTGGATATTCATAAGGAGAAAGTGGCACGAAGAGAGATTGGTATTTTGACAACAAATAAGAATACATCAAGAACTCACAAAATAATAGCACCTGCGAATATGGAGCGCCCTGTAAGGTATATTCGGAAACCTATCGATTACACAGTTCTGGATGATGTGGGCCATGGTGTCAAGCATGGAAATAACCAGCCTGCAAGAACTGGCACACTGTCGAGAACAAATCCTCCTACTCAGAAACCGCCAAGTCCTCCCATGTCAGGCCGGGGAACACTGGGACGGAATACTCCTTATAAAACCCTGGAACCTGTTAAACCCCCAACAGTTCCTAATGACTATATGACCAGTCCTGCTAGGCTTGGAAGTCAGCATAGTCCAGGCAGGACAGCATCTTTAAATCAGAGACCAAGGACACACAGTGGAAGTAGTGGAGGAAGTGGAAGTCGAGAAAACAGTGGTAGCAGTAGTATTGGCATTCCCATTGCTGTGCCTACACCTTCGCCACCCACTATTGGACCAGTTGCTGATAGTCCAACTCCACCGCCACCACCTCCACCAGATGACATTCCCATGTTTGATGACTCTccacctcccccaccaccaccaccaGTGGATTATGAAGATGAGGAGGCTGCAGTAGTTCAGTATAATGATCCATATGCAGATGGGGATCCTGCTTGGGCCCCCAAGAATTATATTGAGAAAGTTGTTGCAATATATGATTATACAAAAGACAAGGATGATGAGCTGTCATTTATGGAGGGTGCAATCATTTATGTTATAAAGAAGAATGATGATGGCTGGTATGAAGGAGTCTGCAATCGAGTGACTGGTCTGTTCCCTGGGAACTATGTTGAATCAATCATGCACTATACTGATTAATTTTTTTTTTTCTTTTGAAGTAGATTCTTATTACTCAGTCATACTGTGGGACTATTATGGTTAACAGAACTGTCTTAATATGTTTTAAAATGTGCCCATATTTTCAGAACATGCTGTTTTATTGGTAAATTGAATGTCTACCTGTAAGCATAAATCTTTGAGGCAGTTTATGTATTGCTGAATAGCAATTTATACAAGAAGCTGTCCATAACTGATTATGCTTATGTACTTACTTACACATTTTTAACTTTATGACCAGCCTAAATATTCTGGGGGAAGTGGGGTATAATATTTAACGAATCATGATTCAGATTGTACCATTACATGTTTCAGTGCAGCATGGTTACTAACGCTATGTCAGACTAATATTAAAATCAGAAAATTTAAATGCTGGTGCTGGTCAGACTTTTTTTGTTAGATTCTCTCATTTAAAAAAAATACTGTTTGTTTAAAGCATGCATAAAAATTTATGTATTGAAATATACTTAAAAATTCAAGATGCTTCCCATTTGTGTAATATTTACCTGGAGGACTCGTACTTAGGTGTCTTAACGTGAATTGAGTCTCCAAGGTCTCCATGTGAAACAAGCAAAAAGAGAATTATCTGTAATGTTGTAATTTGTACCTAAGTTTTTTAATGAGTGAAATTTGCATTATAAACTTTTTCCATTCATAAATACATAAGTGAACCAAAGGTTTTTGTCCTTTCCTTCACTGATTTGCTTTAAAAAAAATAAAAGATAATGATTTATTGCAGAATTATGATTCTATTTTCTCAATATGTTAACTTGGAAAAAAATTTTAGCCTTATCTTAATCTGTCCCAACAGCAATGTGACGGATTTTTGCAGATTCAAAATCTGCAATGGTTATTTACAAGTCAATCTACTGAATTCCTTTTTTAAATAATCTTTTGAAACTAAGAAAATGTGTCAAATTGTGTGCATTCATTCTGTAGGTAAAATTCTTAAGGATTGCCATGTCAGTCCTTCAGTTGTACAGTGAACTGTTGTACACTGGTTCAATGAAAGGAAGTTAAAAGTACCTTTTACATATTGTAAAAGTGGATACAGTTGATTTGTGAGTAGGCACTCTTTAATCCATTACCTGGCACTAGCAACATTAGAATTTTAAAATAAAATAATTGGGAAAGAAGGTGGGTCATGTATTAATCAGTGAACAGAGATTTACCTAACCAACAGACTTGGATTGTCTTTTGACATAATCAAAATGCAACACATGCACTTTGTGTGTCTCCTCTTAATTGAAGGGAGGGCTGAGGGATGTTTTCTCTTCTTGTCTTGTGTATAATTCTCTATTGCTTAGGATATTAAAGTAGAGCACTCAAGTGTGGGTTTCTGTGTTATTGAGGATTTGTTTGGAATTCAAATTACAGTTATGTACTGGATGCTACAGACTTATAACAGCATAGTGAATGGTAAGACTAGTGCAAAACAGTTATTTCTGAAAATTAAAGACCATTATTGCTACCAAATCAATGTGACTATTTCATATGCATTTTGCCTTTGTTAATTTTAAACAAACAAAGTATCATTAGTGATCAGCTAGCTACCTTCTACTTTCCATTTTTCAAGTGGATTGTTCTCTTAATTTGTATATAACCTGTTGTCTAAATTTTATGTACAGTCTTTTATAATAAACCATTCTCCTATATGAAATTTTGGATACTGTTAAAATATAACTCATGTGGACTTCAATGCAGACTTCACATTTTTCTGACCTTTACTCCTACGGTAAATCAAGACAAACCATTTGAATTTTAACATTGGTTATTTATTTGTGTAATGGCCTTACATGTGGATATTAACAGTGTAAACAATACCACATATAACCATCAAGATACCTTGATTATAATTTATAGGACTAGAATGACAGATTCAGGTGGTTTATTAATTACATTTAAAAAGTTTTCTGAAAAAACTTTTGCAATAAAAAAAAATAAATTGCCCATCAA

Publications

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