Summary

Gene Name	Ctsh
Specie	Mus musculus
Full Name	cathepsin H
Also known as	-
Coordinate	chr9:89936320-89958148
Strand	+
Gene summary	This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]

Retrocopy(s) from Ctsh

Retroname	Coord	Strand	Genomic Region	ENSG
CtshP1	chrX:76333229-76334462	-	Intergenic	ENSMUSG00000084202	UCSC

Expression

Transcript Sequences

>NM_007801.3

GAAGGCCAGGGAGCTATGGTTCAAGAAACCTTCACGGAGACGGAGTTACCAGAGATGGGGACAGACAGGAAACTGGGGATTAGGCTGCGCTTCCTCCCACTTGGCAGGGACTAGCCTTCAGGGTCAGACCCTGAGAACCCTTCTTCCCAAGAGCAGGAGTGTAATGGCCACAGGGGGCAGGAGAGGAACCATCATCACCTAGGCGGAGGCCAGAGTCGCCCCACCTCCTTTCCACAGGCTGGGCTCAGAGGGCACTCGGTGGGACCGGGCAGTGAGCGCCGAGATGTGGGCTGCGCTGCCGCTGCTGTGCGCTGGGGCCTGGCTGCTGAGTACTGGGGCCACCGCCGAGCTGACCGTGAACGCCATAGaaaaGTTTCACTTTAAGTCATGGATGAAACAGCATCAAAAGACGTACAGCTCGGTGGAGTACAACCACAGACTGCAGATGTTTGCCAACAACTGGAGGAAGATTCAAGCCCACAACCAGAGGAACCACACATTTAAAAtggcATTGAACCAGTTTTCAGATATGAGCTTTgctgaaataaaacacaaattccTTTGGTCAGAGCCTCAGAATTGCTCAGCCACCAAAAGTAACTACCTCCGAGGTACAGGCCCCTACCCTTCCTCCATGgactggaggaagaaaggaaatgttGTTTCGCCAGTGAAAAATCAGggGGCCTGTGGCAGCTGCTGGACTTTCTCTACCACGGGGGCCCTAGAGTCAGCTGTGGCTATTGCCAGtgggaaaatgctgtctttgGCTGAGCAGCAGCTGGTGGATTGTGCCCAAGCCTTCAACAATCATGGCTGCAAAGGAGGTCTCCCCAGCCAGGCCTTCGAGTACATCCTATACAACAAGGGCATCATGGAAGAAGACAGCTACCCTTACATAGGCAAGGATAGTTCATGCAGATTCAACCCCCAAAAAGCTGTTGCATTCGTCAAGAATGTTGTCAACATCACACTCAATGACGAGGCTGCAATGGTTGAGGCTGTGGCTCTATACAACCCTGTGAGCTTCGCCTTTGAGGTGACTGAAGATTTTTTGATGTATAAAAGTGGCGTCTACTCCAGtaaATCCTGTCATAAAACTCCAGATAAAGTAAACCATGCAGTCCTGGCGGTTGGCTATGGAGAACAGAATGGATTACTCTACTGGATTGTGAAAAACTCTTGGGGCTCCCAGTGGGGGGAGAATGGGTACTTCCTCATTGAACGTGGGAAGAACATGTGTGGCCTGGCTGCTTGTGCCTCCTATCCCATTCCTCAGGTATAAGCCACGGCTGCACGGGCAACTGATTGGCAGACCAAGGGAGGAACTGGTCCTTCGATGAGAATGCCACCCTGGAGAAAATTGTGTGGAAATCCACCCAGAGGCCCTCTCACTCCTGAGTCTAGACGCCTAAAGACAGGAAGGACAAACTTGAATAGCGACAAGCCCACCCACGTGACATCATCACCAGAAATACGCTTGGATTGTGGTTTTTTAATGACCCAAACCCACGTGGACCTAGAATCGTCTCTCTTTCCAGCTCTCTTCATGTACTGGGAGCTGTAATGGTTACCTTTTCTATGTTGTGTATTCAATAAACACACAGTAAATACCTCCCTGGG