Summary

Gene Name	VPS37A
Specie	Homo sapiens
Full Name	VPS37A subunit of ESCRT-I
Also known as	HCRP1|PQBP2|SPG53
Coordinate	chr8:17246927-17333455
Strand	+
Gene summary	This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Retrocopy(s) from VPS37A

Retroname	Coord	Strand	Genomic Region	ENSG
VPS37AP1	chr5:154493289-154495080	+	Intergenic	ENSG00000253886	UCSC

Expression

Transcript Sequences

>XM_017013021.2

ACGCAAGTGACGGCGGCGCGGGTGGTGGAGCGCTGGGCGGCCAGGCTCCCTGGCTGGCCGGTTTGGGCGTCTGGGCCGTGAAGGTGGGACCTCCTGTTCCGGGCCGCAAGTTTCCCTCTCCAGCCGCCCGCCGTTCGTAGCATGTCCCCCAGAACTCGGGGAGCGCAGGCAGGACAGGCTTAGAGAAGACGCGGTCCCCAGCGCTTGGGCCACGGACGTCCCACCCCGCTCCTCTGTCGCTGGAGAACCGCCGGGCCGAGCCACTGGGAGAAGCAGGCCAGAGCCTTCCAGGGCCTCCGGCCCGTGGACCCGAGGAGGATGAGCTGGCTTTTTCCCCTGACCAAGAGCGCCTCCTCCTCCGCGGCTGGGTCCCCCGGTGGCCTCACCAGCCTCCAGCAGCAGAAGCAGCGCCTGATCGAGTCCCTCCGGAACTCACACTCCAGTATAGCCGAAATACAGAAAGATGTGGAATACAGATTGCCATTCACCATAAACAACCTGACAATTAACATTAATATATTGCTTCCTCCACAGTTTCCTCAGGAAAAACCAGTGATCAGTGTTTATCCACCAATACGACATCACTTAATGGATAAACAAGGAGTGTATGTTACCTCTCCATTAGTAAACAATTTTACAATGCACTCAGATCTTGGAAAAATTATTCAGAGTCTGTTGGATGAGTTTTGGAAGAATCCTCCAGTTTTAGCTCCTACTTCAACAGCATTTCCTTATCTATACAGTAACCCAAGTGGGATGTCTCCTTATGCTTCTCAGGGTTTTCCATTTCTTCCTCCATATCCTCCACAAGAAGCAAACAGGAGTATCACTTCTTTATCTGTTGCTGACACTGTTTCTTCTTCAACAACAAGTCATACCACAGCCAAGCCTGCCGCTCCTTCATTTGGTGTCCTTTCAAATCTGCCATTACCCATTCCCACAGTGGATGCTTCAATACCGACAAGCCAAAATGGTTTTGGGTACAAGATGCCAGATGTCCCTGATGCATTTCCAGAACTCTCAGAACTAAGTGTGTCACAACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAACAGTTTCTGACTTTGCCTCAACTAAAACAAATTATTACCGACAAAGATGACTTAGTAAAAAGTATTGAGGAACTAGCAAGAAAAAATCTCCTTTTGGAGCCCAGCTTGGAAGCCAAAAGACAAACTGTTTTAGATAAGTATGAATTACTTACACAGATGAAGTCCACTTTCGAAAAGAAGATGCAAAGGCAGCATGAACTTAGTGAGAGCTGTAGTGCAAGTGCCCTTCAGGCAAGATTGAAAGTAGCTGCACATGAAGCTGAGGAAGAATCTGATAATATTGCAGAAGACTTCTTGGAGGGAAAGATGGAAATAGATGATTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCACTGTAGAAGAGCCAAGGAAGAGAAACTTCAGCAGGCGATAGCAATGCACAGCCAATTTCATGCTCCACTATAGACATACACTGTCAAACGGAAGAAATTAAAGCCACATCCTCAATATTAGGCAACAGAGTTTCTAAGAGTGGACAGCTCCAAGAAGGTTGTGAAGTGAGTTATGTTATGTTATAAAAATGTGAAAGCCATTACCACTATATCCTAAGTTTTATTTTAGCAAGGTATTCCCTATTACATATAGTATATTGCAGAAAATGAATAAACATTCCTTGTACTTAATTTGGGAACTGCTCAGCAGAGAATGCCCAAATTTTATATTCTGAAAGAATTAATTACACTTGCTTTATTTTTTACATTAACAGTACTTTTAAATCACAGTTCTCTAATATATTCTATATTTTTAAATATGATGAACACAATTAAATGTTTTCATTTATATATATTGCAACACTCCCTCCAAATCTTTCATACTAGAGAGATCAGCAATGTTGCTTTCTTGCCCTCGTCCTCATTTCAGCGAAATGTAATAATTCTCCCATTAAAAAAAATCAGATATTCAAAATATTGATGTAAATTGTAAAGTTTAAATTAATCCTTTCACATATTCAAAATATTGATCTAAATTGTAAAGTTTAATCCTTTTACATTCTAGAATGTACTAATATATTAAAACCATACAGTGTGAATACCATTTATTTATGTCCAAACATGGCCACTTTTCCCCACTAAGTTTAATTTAGGTCACCTAGTGAAGTCTTTTTTAACTCATAAGATAGGGGAGGGACTCTCCCTTAAATGTGCAGTGTAACAAAACAAAAATTCTTTTCAGAACTTTCAGCAGTCAGTGGTCATGAGATGTTACTAAGGTTAATTAAACCATATTAGCCAGTTACATAATTTCTAAAATGATAGATTACAAAACCTATTCCCTTCATTAAACAGACATGACAACCCAATTCTCTGGTTCTTGAAACTGGATTTTCACTCACAGATGTTTTATCTACTAACTTTATAATGTGATACTTTGAGATCAGGCTGGTGGCTGGCCCACACTGTCGGTAGTGTAGTCTCTAGAACAGTAATAAAAGGTTATTACAAGAAAGCTGATACTTAAATTCATATGTAAGACCAGGAGAATGAATGTTGCTTCTACCTCGTTAGCTATTAAATCAGTGTTAGAGAAAAAGTGAGATACAAGGTTTAGCATTTTTAAATAATGAGGAGAAACAGACTATAGATCTCAGAGAAAAGCAACAAAATTATTCTCACAATTCAAAATATATGCTCCAAGGAAAAGTTAAAGTGATGATTATGCCTGAAAGATAAGCAATTAAAAGCTCCTTAGGAATGCATCTATTAACTAAAAAGGGTGCATCTCACCAATGTGCCTGTTTTTAGAAATATGTATAAGAGGGTCGGAAAGGAGGATAATGTCAGATGCTTTAGAAAACACAAAATATGCATCTAGAAGTGAACTAAAAGAATCATGATGATCACAGATGTGAGGGAAAGGAGTGGAGGCTTTTTGAGAGATGCATGCTATGACAAGGAAGATAGATACTGATCACTTCAGGTAATGACAGAAGTAATTGCTCTGCAGTGAATATAATTTTCATAGTCTAGGGTGAGCTTCAAAATGGTGAATAATTTTCCTTATATTTGATAAATGAAATGACTACGTCCTCTTCAGTATCTAAGAAATCAAGAACTGGGCACTTTTTTCCCTTTTCATAGCTGCATTAAAGTAGTTCTCAATGACATGCACCATTTCCTGTTTTTACAATAAACCACCTTGTTCCCTTGTTTTTGGAAGTGTTGCTTATGTGTCCTTTACTTTGGAACTCCAAAGGGAAACTTCAGGCAGTGAGAAACACGGCTTCATCAGAATCCCGGTCCTTGCCACTATCTTCACTCGGTGCATGCTCACCACCACTTGGAGACCGACAGCTCAAATCCTCCACCCCGGACTCTTGGTCACTGTTGGCTGACAGATCTGGATCTGAACTTTTCAGATTGTCTTGGGTTAGAATCAGAGCAGAATCTTCATCGCCTTGTGAAGGGCTCCGGGATGGAAATGATTTCATATTCCCACTGTAATCCTGGGGAGTGTTGGCTATGCTGTTGTCTGAGGTAGAAAACCCTGAGTGCTTGCTGGGCTCACTTTGCTTACTCTTCACCTTAGTGCAATTTAACTGGACCTTTTGAATTTTTTCCAGCCTCTAA