Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name VPS37AP1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:154493289-154495080  UCSC
Coordinates (T2T) chr5:155027240-155029031  UCSC
Coordinates (hg19) chr5:153872849-153874640  UCSC
Strand +
Parental Sequence XM_017013021.2
Parental seq. overlap 1665 bp
Parental seq. overlap (%) 45.2%
Genomic Region Intergenic
Retrocopy Summary VPS37AP1, located on chr5:154493289-154495080, is a retrocopy of the parental gene VPS37A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name VPS37A
Full Name VPS37A subunit of ESCRT-I
Also known as HCRP1|PQBP2|SPG53
Coordinate chr8:17246927-17333455
Strand +
Gene summary This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes VPS37AP1
Bonobo Pan paniscus VPS37AP1
Gorilla Gorilla gorilla VPS37AP1
Orangutan Pongo abelii VPS37AP1
Gibbon Nomascus leucogenys VPS37AP1
Green monkey Chlorocebus sabaeus VPS37AP1
Crab-eating macaque Macaca fascicularis VPS37AP1
Rhesus Macaca mulatta VPS37AP1
Baboon Papio anubis VPS37AP1
Golden snub-nosed monkey Rhinopithecus roxellana VPS37AP1
Marmoset Callithrix jacchus VPS37AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>VPS37AP1
AGGTGGTGGAGCGCTGGGCGATCAGGCTGCCTAACTGGCCGGCTTGGGCGTCTGGGCGGTGAAGGTGGGACTGCCTGTTCTGGGCAGCAAGTTCCCCTCTCCAGCTGCCCGCCATTCATAACATGTCCGCCAGAACCCGGGAAGCACAGGCAGGGCTGGCTTAGAGAAGACGCGGTCCCCAGCGCTTGGGCCACGGACGTCCCAGCCCGGTCCTCTGTCGCAGGAGAACCGCTGGGCCGAGCCGCTGGGAGAAGCAGGCCAGAGCCTTCCAGAGCCTCCGCCCGAGGACCTGACAAAGAGCGCCTCCTCCTCCGCAGCCGGGTTCCCGGTGGCCTTACCAGCCTCCAGCAGCAGAAGCAACGCCTGATCGAGTCCCTCCGGAACTCACACTCCAGTATAGCTAAAATACAGAAAGATGTGGAATACAGATTGCCATTCACCATAAACAACCTGACAATTAACATATATTGCTTCCTCCACAATTTCCTCAGGAAAAACCAGTGATCAGTGTTTTTCCACCAATACGACATCACTTAATGGATAAACAAGGAGTGTATGTTACTTCTCCATTAGCAAACAATTTTACAATGCACCCAGATCTTGGAAAAATTATTCAGAGTCTGTTGGATGAGTTTTGGAAGAATCCTCCAGTTTTAGCTCCTACTGCAACAGCATTTCCTTACCTATACAGTAACCCAAGTGGGATGCCGCTTTATGCTTCTCAATGTTTTCCATTTCTTCCTCCATATCCCCCAGAAGAAACAAAGAGGAGTTATCACTTCTTTATCTGTTGCTAATACTGTTTCTTCTTCAACAACAAGTCATACCACAGCCAAGCCCGTCGCTCCTTCATTTGGTGTCCTTTCAAATCTGCCATTACCCATTTCCACAACAGATGCTTCAATATTGACAAGCCAAAATGGTTTTGGTTACAAGATGCCAGATGTCTCTGATGCATTTCCAGAACTCTCAGAACTAAGCGTGTCACGACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAACAGTTTCTGACTTTGTCTCAACTAAAACAAATTATTACTGACAAAGATGACTTAGTAAAAAGTATTGAGGAACTAGCAAGAAAAAAATATCCTTTTGGAGCCCAGCTTGGGAGCCAAAAGGCAAACCGTTTTAGATAAGTATGAATTACTTAAACAAATGAAGTCTGCTTTCAAAAAGAAGATGCAAAGGCAGTGTGAACTTAGTGAGAGCTGTAGTGCAAGTGCCCTACAGGCAACATTGAAAGTAGCTGCACATGAAGCTGGGGAAGAACCTGATAATATTGTGGAAGACTTTGTGGAGGGAAAAATGGAAATAAATGATTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCACTGTAGAAGAGCCAAGGAAGAGAAACTTCAGCAGGCAATAGCAATGCATAGCCAATTTCATGCTCCACTATAGACATACACTGCCAAATGGAAGAAATTAAAGCCGCTTCCTCAATATTAGGCAACAAAGTTTCTAAGAGTGGGCAGCTACAAGAATGGCGTGTAGTGAGTTATGTTATAAAAATGTGAAAGCCATTACCACTATATCCTAAGTATTTATCATTTTAGCAAGGTATTCCCTGTTACATACAGTATATGGCAGAAAATGAATATACATTCCTTGTACTTAATTTGGGAACTGCTCAGCAGGTAATGCTCAAATTTTATATTCTAAAAGAATTACACTTGCTTTATTTTTTACATTAACAGAGTACTTTTATATCACAGTTCTTTAGTATA
>XM_017013021.2
ACGCAAGTGACGGCGGCGCGGGTGGTGGAGCGCTGGGCGGCCAGGCTCCCTGGCTGGCCGGTTTGGGCGTCTGGGCCGTGAAGGTGGGACCTCCTGTTCCGGGCCGCAAGTTTCCCTCTCCAGCCGCCCGCCGTTCGTAGCATGTCCCCCAGAACTCGGGGAGCGCAGGCAGGACAGGCTTAGAGAAGACGCGGTCCCCAGCGCTTGGGCCACGGACGTCCCACCCCGCTCCTCTGTCGCTGGAGAACCGCCGGGCCGAGCCACTGGGAGAAGCAGGCCAGAGCCTTCCAGGGCCTCCGGCCCGTGGACCCGAGGAGGATGAGCTGGCTTTTTCCCCTGACCAAGAGCGCCTCCTCCTCCGCGGCTGGGTCCCCCGGTGGCCTCACCAGCCTCCAGCAGCAGAAGCAGCGCCTGATCGAGTCCCTCCGGAACTCACACTCCAGTATAGCCGAAATACAGAAAGATGTGGAATACAGATTGCCATTCACCATAAACAACCTGACAATTAACATTAATATATTGCTTCCTCCACAGTTTCCTCAGGAAAAACCAGTGATCAGTGTTTATCCACCAATACGACATCACTTAATGGATAAACAAGGAGTGTATGTTACCTCTCCATTAGTAAACAATTTTACAATGCACTCAGATCTTGGAAAAATTATTCAGAGTCTGTTGGATGAGTTTTGGAAGAATCCTCCAGTTTTAGCTCCTACTTCAACAGCATTTCCTTATCTATACAGTAACCCAAGTGGGATGTCTCCTTATGCTTCTCAGGGTTTTCCATTTCTTCCTCCATATCCTCCACAAGAAGCAAACAGGAGTATCACTTCTTTATCTGTTGCTGACACTGTTTCTTCTTCAACAACAAGTCATACCACAGCCAAGCCTGCCGCTCCTTCATTTGGTGTCCTTTCAAATCTGCCATTACCCATTCCCACAGTGGATGCTTCAATACCGACAAGCCAAAATGGTTTTGGGTACAAGATGCCAGATGTCCCTGATGCATTTCCAGAACTCTCAGAACTAAGTGTGTCACAACTCACAGATATGAATGAACAAGAGGAGGTATTACTAGAACAGTTTCTGACTTTGCCTCAACTAAAACAAATTATTACCGACAAAGATGACTTAGTAAAAAGTATTGAGGAACTAGCAAGAAAAAATCTCCTTTTGGAGCCCAGCTTGGAAGCCAAAAGACAAACTGTTTTAGATAAGTATGAATTACTTACACAGATGAAGTCCACTTTCGAAAAGAAGATGCAAAGGCAGCATGAACTTAGTGAGAGCTGTAGTGCAAGTGCCCTTCAGGCAAGATTGAAAGTAGCTGCACATGAAGCTGAGGAAGAATCTGATAATATTGCAGAAGACTTCTTGGAGGGAAAGATGGAAATAGATGATTTTCTCAGTAGCTTCATGGAAAAGAGAACAATTTGCCACTGTAGAAGAGCCAAGGAAGAGAAACTTCAGCAGGCGATAGCAATGCACAGCCAATTTCATGCTCCACTATAGACATACACTGTCAAACGGAAGAAATTAAAGCCACATCCTCAATATTAGGCAACAGAGTTTCTAAGAGTGGACAGCTCCAAGAAGGTTGTGAAGTGAGTTATGTTATGTTATAAAAATGTGAAAGCCATTACCACTATATCCTAAGTTTTATTTTAGCAAGGTATTCCCTATTACATATAGTATATTGCAGAAAATGAATAAACATTCCTTGTACTTAATTTGGGAACTGCTCAGCAGAGAATGCCCAAATTTTATATTCTGAAAGAATTAATTACACTTGCTTTATTTTTTACATTAACAGTACTTTTAAATCACAGTTCTCTAATATATTCTATATTTTTAAATATGATGAACACAATTAAATGTTTTCATTTATATATATTGCAACACTCCCTCCAAATCTTTCATACTAGAGAGATCAGCAATGTTGCTTTCTTGCCCTCGTCCTCATTTCAGCGAAATGTAATAATTCTCCCATTAAAAAAAATCAGATATTCAAAATATTGATGTAAATTGTAAAGTTTAAATTAATCCTTTCACATATTCAAAATATTGATCTAAATTGTAAAGTTTAATCCTTTTACATTCTAGAATGTACTAATATATTAAAACCATACAGTGTGAATACCATTTATTTATGTCCAAACATGGCCACTTTTCCCCACTAAGTTTAATTTAGGTCACCTAGTGAAGTCTTTTTTAACTCATAAGATAGGGGAGGGACTCTCCCTTAAATGTGCAGTGTAACAAAACAAAAATTCTTTTCAGAACTTTCAGCAGTCAGTGGTCATGAGATGTTACTAAGGTTAATTAAACCATATTAGCCAGTTACATAATTTCTAAAATGATAGATTACAAAACCTATTCCCTTCATTAAACAGACATGACAACCCAATTCTCTGGTTCTTGAAACTGGATTTTCACTCACAGATGTTTTATCTACTAACTTTATAATGTGATACTTTGAGATCAGGCTGGTGGCTGGCCCACACTGTCGGTAGTGTAGTCTCTAGAACAGTAATAAAAGGTTATTACAAGAAAGCTGATACTTAAATTCATATGTAAGACCAGGAGAATGAATGTTGCTTCTACCTCGTTAGCTATTAAATCAGTGTTAGAGAAAAAGTGAGATACAAGGTTTAGCATTTTTAAATAATGAGGAGAAACAGACTATAGATCTCAGAGAAAAGCAACAAAATTATTCTCACAATTCAAAATATATGCTCCAAGGAAAAGTTAAAGTGATGATTATGCCTGAAAGATAAGCAATTAAAAGCTCCTTAGGAATGCATCTATTAACTAAAAAGGGTGCATCTCACCAATGTGCCTGTTTTTAGAAATATGTATAAGAGGGTCGGAAAGGAGGATAATGTCAGATGCTTTAGAAAACACAAAATATGCATCTAGAAGTGAACTAAAAGAATCATGATGATCACAGATGTGAGGGAAAGGAGTGGAGGCTTTTTGAGAGATGCATGCTATGACAAGGAAGATAGATACTGATCACTTCAGGTAATGACAGAAGTAATTGCTCTGCAGTGAATATAATTTTCATAGTCTAGGGTGAGCTTCAAAATGGTGAATAATTTTCCTTATATTTGATAAATGAAATGACTACGTCCTCTTCAGTATCTAAGAAATCAAGAACTGGGCACTTTTTTCCCTTTTCATAGCTGCATTAAAGTAGTTCTCAATGACATGCACCATTTCCTGTTTTTACAATAAACCACCTTGTTCCCTTGTTTTTGGAAGTGTTGCTTATGTGTCCTTTACTTTGGAACTCCAAAGGGAAACTTCAGGCAGTGAGAAACACGGCTTCATCAGAATCCCGGTCCTTGCCACTATCTTCACTCGGTGCATGCTCACCACCACTTGGAGACCGACAGCTCAAATCCTCCACCCCGGACTCTTGGTCACTGTTGGCTGACAGATCTGGATCTGAACTTTTCAGATTGTCTTGGGTTAGAATCAGAGCAGAATCTTCATCGCCTTGTGAAGGGCTCCGGGATGGAAATGATTTCATATTCCCACTGTAATCCTGGGGAGTGTTGGCTATGCTGTTGTCTGAGGTAGAAAACCCTGAGTGCTTGCTGGGCTCACTTTGCTTACTCTTCACCTTAGTGCAATTTAACTGGACCTTTTGAATTTTTTCCAGCCTCTAA

Publications

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