Summary

Gene Name	DFFB
Specie	Homo sapiens
Full Name	DNA fragmentation factor subunit beta
Also known as	CAD|CPAN|DFF-40|DFF2|DFF40
Coordinate	chr1:3857286-3885429
Strand	+
Gene summary	Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]

Retrocopy(s) from DFFB

Retroname	Coord	Strand	Genomic Region	ENSG
DFFBP1	chr9:32564450-32567187	-	Intragenic	ENSG00000232303	UCSC

Expression

Transcript Sequences

>NM_004402.4

ACCCGGCCTGTGCCAGCTTGCAGAGCTCACCAGGTGCAGACCCCTGCGGCCAGGGCGAGGACGGATCTGAGCAGCTGGGCAGCAGGTGCCACCGCCTGTGGGACCCAGAGGGCTTGAGGACATCTGCAATGCTCCAGAAGCCCAAGAGCGTGAAGCTGCGGGCCCTGCGCAGCCCGAGGAAGTTCGGCGTGGCTGGCCGGAGCTGCCAGGAGGTGCTGCGCAAGGGCTGTCTCCGCTTCCAGCTCCCTGAGCGCGGTTCCCGGCTGTGCCTGTACGAGGATGGCACGGAGCTGACGGAAGATTACTTCCCCAGTGTTCCCGACAACGCCGAGCTGGTGCTGCTCACCTTGGGCCAGGCCTGGCAGGGCTATGTGAGCGACATCAGGCGCTTCCTCAGTGCATTTCACGAGCCACAGGTGGGGCTCATCCAGGCCGCCCAGCAGCTGCTGTGTGATGAGCAGGCCCCACAGAGGCAGAGGCTGCTGGCTGACCTCCTGCACAACGTCAGCCAGAACATCGCGGCCGAGACCCGGGCTGAGGACCCGCCGTGGTTTGAAGGCTTGGAGTCCCGATTTCAGAGCAAGTCTGGCTATCTGAGATACAGCTGTGAGAGCCGGATCCGGAGTTACCTGAGGGAGGTGAGCTCCTACCCCTCCACGGTGGGTGCGGAGGCTCAGGAGGAATTCCTGCGGGTCCTCGGCTCCATGTGCCAGAGGCTCCGGTCCATGCAGTACAATGGCAGCTACTTCGACAGAGGAGCCAAGGGCGGCAGCCGCCTCTGCACACCGGAAGGCTGGTTCTCCTGCCAGGGTCCCTTTGACATGGACAGCTGCTTATCAAGACACTCCATCAACCCCTACAGTAACAGGGAGAGCAGGATCCTCTTCAGCACCTGGAACCTGGATCACATAATAGAAAAGAAACGCACCATCATTCCTACACTGGTGGAAGCAATTAAGGAACAAGATGGAAGAGAAGTGGACTGGGAGTATTTTTATGGCCTGCTTTTTACCTCAGAGAACCTAAAACTAGTGCACATTGTCTGCCATAAGAAAACCACCCACAAGCTCAACTGTGACCCAAGCAGAATCTACAAACCCCAGACAAGGTTGAAGCGGAAGCAGCCTGTGCGGAAACGCCAGTGACACGTACACACCACGTCCTGGTCTTTGTTTGAGGCCTGACGTGGGCATCATTTTAACAGGTGCCttttttgtttttttgtttttcgtttttttGGTCACTCCAGTAGCTCCTGGAAAAAACCTTAAAAAATGTTTCCTCCAAATCTGATTTCATTACATTTCTGAATTGTTGGGGTTTTTTttgttgttttgttttgttttgtagatggagtttcacttttgttgcccaggctggagtgtagtggcgcgatctcggctcagcctcccgagtagctgggattacaggcatgtgccaccacgcccggctaatgtttgtatttttagtagagacggggtttcaccatgttggtcaggctggtctcaaactcctgacctcaggtgatccgcccacctcagcctcccaaagtgctgggatgacaggtgtgagccactgcgcccagccTGAATCATTTCTTATACCTTCTGACAGCCCAACTTCCAGAGGACAGCTCTGGGGTACTCGTTGGATGTCTGTGAGTACCTGGTCATACGGGTCAGTAGGGATAAGAATTGTCTCTGGGCTGAGGAATTCTTCTGTTCTCTGGTTTCACCAGCGTTGGGTTTGCTCATGTAATGTGGTCACCATACTCAAATGGTGTCATGGCTGAAGTTGGCCACCTTGCTTGAGGGACAAGTTGTTTATGTATCAGCTCTCTGCTGGGTCTCCCTTTCCATGGCAAATGGGCAGCTCCATCCTCTTGACTCTTCTAAATGCCCAAAAGAGGTGTCATGCTTTGGGGGTACGATGTTTATACTCCGTAAAGAACATACAAGGACATTCACTGCTGAtttttttttttgtttgtttgagacagggtctcactctgtcgctcaggctggagtgcagtgatgcaatcttggctcactgcaacctccgcctctcaggttcaagtggttctccttcctcagcctcccaagtagctgggattacaggcacctaccaccagggccagctaatttttgtatgtttagtagaaacggggtttcaccatgttggccaggctgttctcgaactcctgacctcaggtgatctgcccgcctcggtctcccaaagtgctgggattacaggcatgagccactgcacctgaccTGCTGAATTGTTTATAATGGCAAGAAATAGGAAACCCCCCAATGTCTGTTGAACAGCTATCACgttgaaccacgtgaaactgctgttttctaggccaaaaatggtgagcgatcatttatttcatgattcaacctgaTACATTTACATAGTGCAAAACTGTGTCACAGTTTCAGGCTTTTATGAGGAAAGCGTTTCTGTGTAGAAACTGGAAGCTGTTCAGGGCATCGGCAGCTGAACCCTGCTCCGTTGGTCAGCGTTACTATCATCTCGGATCATATGGAGCTCATGTCAGCCGTGTGGGTGGCGGGTGCACAGAGACGGTCTGGAAGGAAACACGCGGATCTGAACAGCAGTAATCCTGGGGGATACGGGGGTTGGGCTAGATTACAGAGGGCTCATTTTCTACGTCATGTATTTTATGATACTTGAATTTTTTGAAATGGGCATTTATTTTATAACATGTTAAAATGTACTTTTTAAATTAAGTCATTTTGTAATATTTGAATTTTTACATTTGTTGTACAATCAGGAAAAGCAATAAAGATTTTTCAAAAATAGA