Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name DFFBP1
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Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:32564450-32567187  UCSC
Coordinates (T2T) chr9:32580635-32583372  UCSC
Coordinates (hg19) chr9:32564448-32567185  UCSC
Strand -
Parental Sequence NM_004402.4
Parental seq. overlap 1128 bp
Parental seq. overlap (%) 31.6%
Genomic Region Intragenic (NDUFB6)
Retrocopy Summary DFFBP1, located on chr9:32564450-32567187, is a retrocopy of the parental gene DFFB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DFFB
Full Name DNA fragmentation factor subunit beta
Also known as CAD|CPAN|DFF-40|DFF2|DFF40
Coordinate chr1:3857286-3885429
Strand +
Gene summary Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DFFBP1
Bonobo Pan paniscus DFFBP1
Gorilla Gorilla gorilla DFFBP1
Orangutan Pongo abelii DFFBP1
Gibbon Nomascus leucogenys DFFBP1
Green monkey Chlorocebus sabaeus DFFBP1
Crab-eating macaque Macaca fascicularis LOC102142800P1
Rhesus Macaca mulatta DFFBP1
Baboon Papio anubis DFFBP1
Golden snub-nosed monkey Rhinopithecus roxellana DFFBP1
Marmoset Callithrix jacchus DFFBP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.51
log10(TPM+1)

Related Sequence

>DFFBP1
GATACATTTACATAGTGCAAAAGGATGTTGTAGTTTCAAGCTTTTATGAAGAAAGTGTTTCTGTGTAGAAACTGGAAGCTGTTCAGTGCACTGGCAGCTGAACCCTGCTCCTGCTCCATTTATCAGAGTTACTATCATCTCAGATAATATGGAGCTCATGTCAGCAGTGCAGGTGGTGAGTGCGCAGAGACAATCTGGAAGGAAACGCTGATCTGAACAGCAGTAATCCTGGGGGACATGGGGGTGGGACTGGATTACAGAGGACTCATTTTCTAAATCATGTATTTTATGATACTTGAATTTTTTTGAAATGGGCATTTATTTAATGACATGTTATAATGTACTTTTTTTTAAAAAAGTGTAATATTTGAATTTTTACATTTGTTGTGTAATCAGCAGAAGCAATAAAGATTTTTCAGTGAATCATTTTTTGTACCTTCTGACAGCCCAACTTCCAGAGGACAACTTTGGGGTACTCACTGGATGTCTTGTGAGTCGTCAGTAGGGATAAGAATTGTCCTGAGCTGAGGAATTCTTCTGTTCTCTGGTTTTACCAGTATTTGGTTTGCTCATGTGGTGTGGTCACCATACTAAAACGGTGTCATGGCTGAAGTTAGCCACTCTTGTTTGAGGGACAAGTTGTTTATGCATCAGCTGTCTGCTGGCTCTCCATTTCCATGGCAAATGGGCAGCTCCATCCTTCTTGACTGTTCTAAATGCCCAAAAGAGAGGTGTCATGCTTTGGGGGTAAGATGTTTGTACTCCATAAAGAACATAAAAGGACATTCACTGCTGAATGAGCAGCTGGCCAGCGGGTGCCACTGCCTGCGGGGCCCAGAGGCGTTGAGTACATCTGCAGTGCTCCAGAAGCACAAGACTGTGAAGCTGCGGGCCCTGTGCAGCCCGAGGAAGTTTGGCATGGCGGGCAGGAGCTGCCGGGAGATGCTGCGCAAGGGCTACCTCTGCTTCTAGCTCCCTCGTACGAGGATGGCATGGAGCTGACCGAAGCGTCCTCGACGATGCCGAGCTGGTGCTGCTCACCTCACGCCAGGCCTGGCAGGGCTATGTGAGTGACATCGGGTGCTTCCTCAGTGCTTTTCGCCAGCCGCACGCGTGGCTCATCCAGGCCGCCCGGCAGCTACTGTGTGATGAGCAGGCCCCCACAGAGGCAGAGACTGCTGGCCGACCTCCTGTACAACGTCAGCCAGAACGTCGCAGCCGACACCCGGGCTGAGGACCCGCTGTGGTTTGAAGGCTTGGAGTCCCGATTTTGGAATAAGTCTGGCTATCTGAGATACAGCTGTGAAAGCCGGATCCGGAGTTACCTGAGAGAGGTGAGCTCCTGCTCCTCCATGGTGGGTGCAGAGGCTCAGGAGGAATTCCTGCGGGTCCTCCGCTCCATGTGCCAGAAGCTCCAGTCTGTGCAGTACGACGGCAGCTATACAACAGAGGAGCCAAGGGTGGCAGCCGTCTCTGCACACCGGAAGGCTAGTTCTCCTGCCAGGGTCCCTTCGACATGGACGGCTGCTTGTCAAGATACTCCATCAACCCCTACAGTAACAGGGAGAGCAGGCTCCTCTTCTGGACCTGGAACCTGGATCACATAGTGGAAACAAAAACGCACCATCATTCCTACACTGGTGGAAGCAGTTAAAGAACAAGATGGAAGAGAAGTGGACTGGGAATATTTTTATGGCCTGCTTTCTACCTCAGAGAACCTAAAATTAGTGTTGTCTGCCATAAGAAAACCACCCACAAAACCAGCTATGACCTGAACAGAATCTACAAACCCCAGACAAGGTTGAAGAGGAAGTGGCCTGTGTGAAAGCGCCAGTGACATATACACACCATATTCTCGTCTTTGTTCGAGGCCTGTCGTGGGCATAATTTTAACAGGTGCCTTTTTTTTTTTTTGGTCACTCCAGTAGCTCCTGGAAAAAACCTTAAAAAATATTTCCGGCAAATCTGATTTCAGTACATTTCTGAATCATTGt
>NM_004402.4
ACCCGGCCTGTGCCAGCTTGCAGAGCTCACCAGGTGCAGACCCCTGCGGCCAGGGCGAGGACGGATCTGAGCAGCTGGGCAGCAGGTGCCACCGCCTGTGGGACCCAGAGGGCTTGAGGACATCTGCAATGCTCCAGAAGCCCAAGAGCGTGAAGCTGCGGGCCCTGCGCAGCCCGAGGAAGTTCGGCGTGGCTGGCCGGAGCTGCCAGGAGGTGCTGCGCAAGGGCTGTCTCCGCTTCCAGCTCCCTGAGCGCGGTTCCCGGCTGTGCCTGTACGAGGATGGCACGGAGCTGACGGAAGATTACTTCCCCAGTGTTCCCGACAACGCCGAGCTGGTGCTGCTCACCTTGGGCCAGGCCTGGCAGGGCTATGTGAGCGACATCAGGCGCTTCCTCAGTGCATTTCACGAGCCACAGGTGGGGCTCATCCAGGCCGCCCAGCAGCTGCTGTGTGATGAGCAGGCCCCACAGAGGCAGAGGCTGCTGGCTGACCTCCTGCACAACGTCAGCCAGAACATCGCGGCCGAGACCCGGGCTGAGGACCCGCCGTGGTTTGAAGGCTTGGAGTCCCGATTTCAGAGCAAGTCTGGCTATCTGAGATACAGCTGTGAGAGCCGGATCCGGAGTTACCTGAGGGAGGTGAGCTCCTACCCCTCCACGGTGGGTGCGGAGGCTCAGGAGGAATTCCTGCGGGTCCTCGGCTCCATGTGCCAGAGGCTCCGGTCCATGCAGTACAATGGCAGCTACTTCGACAGAGGAGCCAAGGGCGGCAGCCGCCTCTGCACACCGGAAGGCTGGTTCTCCTGCCAGGGTCCCTTTGACATGGACAGCTGCTTATCAAGACACTCCATCAACCCCTACAGTAACAGGGAGAGCAGGATCCTCTTCAGCACCTGGAACCTGGATCACATAATAGAAAAGAAACGCACCATCATTCCTACACTGGTGGAAGCAATTAAGGAACAAGATGGAAGAGAAGTGGACTGGGAGTATTTTTATGGCCTGCTTTTTACCTCAGAGAACCTAAAACTAGTGCACATTGTCTGCCATAAGAAAACCACCCACAAGCTCAACTGTGACCCAAGCAGAATCTACAAACCCCAGACAAGGTTGAAGCGGAAGCAGCCTGTGCGGAAACGCCAGTGACACGTACACACCACGTCCTGGTCTTTGTTTGAGGCCTGACGTGGGCATCATTTTAACAGGTGCCttttttgtttttttgtttttcgtttttttGGTCACTCCAGTAGCTCCTGGAAAAAACCTTAAAAAATGTTTCCTCCAAATCTGATTTCATTACATTTCTGAATTGTTGGGGTTTTTTttgttgttttgttttgttttgtagatggagtttcacttttgttgcccaggctggagtgtagtggcgcgatctcggctcagcctcccgagtagctgggattacaggcatgtgccaccacgcccggctaatgtttgtatttttagtagagacggggtttcaccatgttggtcaggctggtctcaaactcctgacctcaggtgatccgcccacctcagcctcccaaagtgctgggatgacaggtgtgagccactgcgcccagccTGAATCATTTCTTATACCTTCTGACAGCCCAACTTCCAGAGGACAGCTCTGGGGTACTCGTTGGATGTCTGTGAGTACCTGGTCATACGGGTCAGTAGGGATAAGAATTGTCTCTGGGCTGAGGAATTCTTCTGTTCTCTGGTTTCACCAGCGTTGGGTTTGCTCATGTAATGTGGTCACCATACTCAAATGGTGTCATGGCTGAAGTTGGCCACCTTGCTTGAGGGACAAGTTGTTTATGTATCAGCTCTCTGCTGGGTCTCCCTTTCCATGGCAAATGGGCAGCTCCATCCTCTTGACTCTTCTAAATGCCCAAAAGAGGTGTCATGCTTTGGGGGTACGATGTTTATACTCCGTAAAGAACATACAAGGACATTCACTGCTGAtttttttttttgtttgtttgagacagggtctcactctgtcgctcaggctggagtgcagtgatgcaatcttggctcactgcaacctccgcctctcaggttcaagtggttctccttcctcagcctcccaagtagctgggattacaggcacctaccaccagggccagctaatttttgtatgtttagtagaaacggggtttcaccatgttggccaggctgttctcgaactcctgacctcaggtgatctgcccgcctcggtctcccaaagtgctgggattacaggcatgagccactgcacctgaccTGCTGAATTGTTTATAATGGCAAGAAATAGGAAACCCCCCAATGTCTGTTGAACAGCTATCACgttgaaccacgtgaaactgctgttttctaggccaaaaatggtgagcgatcatttatttcatgattcaacctgaTACATTTACATAGTGCAAAACTGTGTCACAGTTTCAGGCTTTTATGAGGAAAGCGTTTCTGTGTAGAAACTGGAAGCTGTTCAGGGCATCGGCAGCTGAACCCTGCTCCGTTGGTCAGCGTTACTATCATCTCGGATCATATGGAGCTCATGTCAGCCGTGTGGGTGGCGGGTGCACAGAGACGGTCTGGAAGGAAACACGCGGATCTGAACAGCAGTAATCCTGGGGGATACGGGGGTTGGGCTAGATTACAGAGGGCTCATTTTCTACGTCATGTATTTTATGATACTTGAATTTTTTGAAATGGGCATTTATTTTATAACATGTTAAAATGTACTTTTTAAATTAAGTCATTTTGTAATATTTGAATTTTTACATTTGTTGTACAATCAGGAAAAGCAATAAAGATTTTTCAAAAATAGA

Publications

PMID - Link Title
No publications available for this retrocopy