Summary

Gene Name	Lrp8
Specie	Mus musculus
Full Name	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Also known as	4932703M08Rik|ApoER2|Lr8b
Coordinate	chr4:107659337-107734037
Strand	+
Gene summary	Enables several functions, including amyloid-beta binding activity; apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of CREB transcription factor activity; and regulation of dendrite development. Acts upstream of or within central nervous system development and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Lrp8

Retroname	Coord	Strand	Genomic Region	ENSG
Lrp8P1	chrY:1291006-1291953	+	Intragenic	N/A	UCSC

Expression

Transcript Sequences

>NM_001369054.1

TGACTATGTATCACTCCTGCGGCGTGGAGTACAGGGACTCACAGAGCCAAGAGGACCTGCGCGGACAGCGACTTCACCTGTGACAATGGCCACTGCATCCCAGAGCGGTGGAAGTGCGACGGCGAGGAGGAGTGTCCCGATGGCTCTGACGAATCGAAGGCCACGTGCTCCAGTGAAGAGTGTCCTGCCGAGAAGTTAAGCTGCGGACCCACCAGCCACAAGTGTGTGCCTGCCTCATGGCGCTGCGACGGAGAGAAGGACTGTGAGGGTGGTGCTGACGAGGCCGGCTGTCCCACCTCACCAGGACCCTGCCGCGAGAATGAGTTCCAGTGTGGGGATGGGACTTGCGTTCTTGCCATCAAACGGTGCAACCAGGAGCGGGACTGCCCGGACGGGAGTGACGAAGCGGGCTGCCTTCAGGGGCTAAATGAGTGTCTGCACAATAACGGCGGCTGTTCCCACATCTGCACTGACCTCAAGATCGGCTTTGAGTGCACGTGCCCAGCAGGCTTCCAGCTCTTGGACCAGAAGACCTGTGGTGACATTGATGAATGCCAGGACCCGGATGCCTGCAGCCAAATCTGCGTGAATTACAAGGGCTACTTTAAGTGTGAATGCCACCCTGGCTATGAGATGGATACACTGACCAAGAACTGCAAAGCTGTAGCCGGCAAGAGCCCATCTCTGATCTTCACGAACCGACACGAGGTGCGGAGGATAGACCTGGTGAAGCGGGACTACTCGCGCCTCATCCCCATGCTCAAGAATGTCGTGGCGCTGGACGTGGAAGTAGCCACCAATCGCATATACTGGTGCGACCTCTCCTACCGCAAGATCTACAGCGCCCACATGGACAAGGCCAGCATCCCGGACGAGCAGGTGGTCCTCATTGATGAGCAGCTGCACTCCCCGGAGGGCCTGGCGGTGGACTGGGTCCATAAGCACATCTACTGGACAGACTCAGGCAATAAGACCATCTCAGTGGCCACAACCGATGGACGCCGCCGCTGTACTCTCTTCAGCCGTGAGCTCAGTGAGCCCCGAGCCATTGCCGTTGACCCCCTGCGAGGGTTCATGTACTGGTCTGACTGGGGTTTCCAGGCAAAGATTGAGAAGGCTGGGCTCAATGGTGCAGACCGGCAAACACTGGTTTCAGACAACATTGAATGGCCCAATGGAATCACCCTGGactTGCTGAGCCAGCGTTTGTACTGGGTGGACTCCAAGCTGCACCAACTATCCAGCATTGACTTCAATGGAGGCAACAGAAAGATGCTGATCTTCTCCACTGACTTCCTGAGTCACCCTTTTGGGGTTGCTGTATTTGAGGACAAGGTATTCTGGACAGACCTGGAGAATGAGGCCATTTTCAGCGCAAATCGGCTCAATGGCCTGGAAATCGCCATCCTGGCCGAGAACCTCAATAACCCACATGACATTGTAATCTTCCACGAGCTGAAGCAGCCAAAGGCTGCAGATGCCTGTGACCTGAGTGCCCAGCCCAACGGCGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAAATCTCCAGCCACTCCCCCAAGTACACGTGTGCCTGTCCTGACACGATGTGGCTGGGCCCAGACATGAAGAGATGCTACCGAGCACCTCAGTCTACCTCAACTACAACCTTAGCCTCTGCCATGACAAGGACAGTACCTGCTACCACAAGAGCTCCTGGGACAACCATCCACGACCCTACCTACCAGAACCATAGCACAGAGACGCCAAGCCAGACAGCTGCCGCCCCTCACTCGGTTAACGTCCCTagggctcccagcaccagcccaTCCACCCCGAGCCCTGCTACCAGCAACCACTCCCAGCATTATGGGAATGAAGGCAGCCAGATGGGCTCAACAGTCACCGCTGCTGTCATTGGGGTCATCGTGCCCATAGTGGTAATAGCCCTGCTATGTATGAGTGGGTACCTCATCTGGAGGAACTGGAAGCGGAAGAACACCAAGAGCATGAATTTCGACAACCCAGTGTACAGGAAAAcgacagaagaggaagaggaagatgagctTCACATAGGGAGGACAGCTCAGATTGGCCACGTCTACCCCGCACGAGTGGCATTAAGTCTTGAAGATGATGGACTGCCCTGAGGATGGGCCCACCCACTTCGTGCCTCATGGAGTTCAGTCCTATGCACTACTCTCTCTGGATGGTGTGTGATTGGATGAGTGCCATTTCTATATAtgggtctgtgtgagtgtgtgtgtgtgtgtgtgtgagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatgtgactttttttaaatttatgttgcgGAAAGGTAACCACAAAGTTATGATGAACTGCAAACATCCAAAGGATGTGAAAGTTTTTATATGTATAATGTTTTATACACTTTTTAACTGGTTGCACTACCCGTGAAGAATTCATGGGACAGCCACTGCTGAGTGACTAACATGATGCACATAACCAAACGGGGCCAATGGTACAAACTTCACTCATCATTTGAATACAGTATTTACAGAGGATGTTTGAGTTGAGAGCTTTTTTAGGTTTGAGGGGCTtgatttttttgtaaataaaattatgCTTTGTGGCTATCCATCAACAtaagtataaaaagaaagaacGCTTCAACCCCCTTCCCCATTTAGATTATTTATTAACATATTTCGAAAGTAAGGTTAGCTCTATAAATAATTTAGAGAGGTGAGAGTATTTATTTTTGGTATGGCTGGCTCACTGCACAgactctgtgtttatgtgtgtgtgtctgtgtgagagaagAAAAATCTGTAGAGAAGAGGCACGCTTATGACTATtgttcaaatacataaaaacagTTATTTTAAAACAGTCCACAAGAGGGGTGTCTAGTTTTCAGAGACACTTCAGAAACTTTGCTCAGAAAACAGATGCTACAGTTTGTGCAGGCATGCGGTAGGAAAGGTAGATCACCTCTGGCTACTCCTGAGGCCCTGCTGAGCCAGCAAAATGCTTTCCAGTTCCTCTTTGGCTCTCACGATGCCCACCTAGGCTTTCTGGCCAGTGTACTGAACAGTGCTACAAGCCCTCAGGAGCTCAAGATAGCAGAGTCCTTCTTTCAAAGCCCAGCTTAGTGAGGACTTGGGTCAACTTCAGTAAGCTTCCTCTGAAGCAACTGAAGGCCGAGCCTTTAGAGCAACCATTGTCAACCTTTGTGGGTCGCCTAAGAGCATCGCaaaccagatatttacattatgattcataacagtgacaatcacagttatgaggtagaaaggaaagggattttatggttgggggttagtCCAACAAGAGGGACAGTGTTAATGCTTCtgaagcatcaggaaggttgaaagCCACTGCTCTAGAGCCAAGTGAGTGCATGTCTAGGGTTCCCATGTTTACAGTAAGGACCGGCTCAGGCACTGACCCTCTGAGTCACGTGAATGAGGACGAAGAATTTGGAATAGGTTTGGTTACATCTATTTCTCATCCCCTTATTTTccaccatttaaaaataataaacatgtttCTTACCACCGTATGTTCATATGGATAAGACTAAGTCCAAAAAGGTGACTACATCCAAATTTATATTTCGGGGAAATACCATGAGATAATTATAGCATACTGGGCATGTGTCCACACACGGATTGGTTTCACTGCTTTATAAATAAAAGGAACAACTCTGGGTATTTGTATAGAATTTTCTTCATATGTAACATCTTTCCATTTCCTgagccttgggggtggggtgggagaatgCCACTTGCTGTCTGTGAAGTCCACTGTTGGAAACATAATTCCATAGTCCCAGAAGGAATTCAGTCCCCACCAACTTACTCTTTCAAAGTGTGGTCTTCCCGCGACTCTGCAGCTCTGCAGTTCACTCCAGCTGAACGACCAGGGACAAGTACAACACAGGAGTTTGGCTTAAGTGGCAGCAGACTAATATCTAAAGTTGACATAACTGAAATCTGACATTTGAGGCATATGTCTCCGCGTCCCCACACACCGGCTTGAGTGGCTCACCTGCTTGATGTCCTTTCAACTTCCGGGGAGACCGTCTGGAGACCTGTCATCCTGTCATCCTGTTCCTAGGAGCTTGCTCTATGTCACTCATGTTTTCCTAACCTTTAAAAAATGGCTGTGTTCCAAGCCTGGCCATTATGTCTGACAATGCACGTGTTGATGGTCTTGAGATATACAGTGACTAAATGCAGCTGACCCCTGACCCATTCCAAACAGTCTCAAGGACAGGCAGCTGAGTCCCCTGCAGCTCGCCTGTCACTGTTCATCCAGGAATGGAGAGGAGAAATCAAGTTTACTAAAGAAAAAGGTTAGAAGTGAAATCATCAAAATTTACACAAGATAGGCAGGGTTTTTCCCTTTAATCTGCCTCCAAGGAAACTGAAGCAGTGATAGTGTATAGTTTCTGAACAAACGTTCATAGCCTAGCCTTCACAACAAGGCTGAAACATACCGTCTAGGGTTTCCGAAAGATGAAAGAATTCATATCAGAAATACCATGTTTCCTGAATGTGCCACAGCTGCAGTCTAAAAGCAGCCTACAGTAAACAGATGGGCAAATCCAGGGACGGCCGGAGAGCGGAAGCACTCTGAGGGACCAGACCGACCTCCTTCTATCCTTGGAAACTTTTTGAGCCTCATTCTGAGGTGTAATTCAGACTTCTGTTGCCTTTCGCCTCTGCCTATGTATCCACAGCCAATAACAGCTGAAAGGAAACTCAGTAATAAACCAAAAGGACAGAAAATTCAACAAACGTTACTTATTAAAACGAAGCCAACCCCTTCCTTCTCTAGAAGACAACTCTGAGCAGCCTGAACAAGGTCTCAGACCTGCATCCTCTCCACAGCTATCTGCCCAGTGGATTGAAGGCACTAACAGAAACGACTTTCCTGAAACAAGAAACTACAGCTTTGTTTACTCTtcagaatgtgtgtatgtgtgtgcacagagggACAGGATGAGACGGCTTCTGACAAGGAGTAAGAAGAATGAGACAGGATTTAAACTGATGTCAGTGAACACTGTTGAAGCCCTCCAGTTATCCTCATGTCTTAGTAACATACTCAGAGTATTCACTCGCTGCTGTGTGCCAGGCTTTGCAGACATTGCAGGTCAATTCAACAGTTTTCACCCTTTCCAAACTCACAGCAGTACATAtggatacaaaaagaaaaaaaaattttcccaTAGATTTCACCTAGACTACTCCCAAGGCACAACAAAAGAGATGGGCCATTTTACCTGAAGAGGTGGAAATAGGTCTACATAGGAATGACCCAAAGCAATGTCTTAAAACTTAAAAAGTGGTGTTCAGGCTGCTTCTATGAGAAGAGGCTGGGCTCAGACTGGGAGTGAATCAGCAGCAGGAATTTCAAGGAAAACATGGAGTTCCTTACACCTGGAATAAAGAACTTTAGCAGGGTTGGCAAGATGTGAAACTGGATGGAAAGACAAGTTCAACACAAGCACTTTATAAAATAGTCTGATGTAAGTAAGCAGACATTTGTTTGGTCGTCGGTTCCTGTGTGCAAGGCATCATGGGAAACTCCctgccagcacttggcaggcattATTCCACCTCAAGCTTTCCAGAGACCACAGGGAaatgactgttttctttatttgagcCAGAGGTTTTGATATGGTTCCTGAAGGCTAACAGAAGGGCGGTGGGCTTGTCAACAGAAGCACGCCATGTTGCCGAGCACCTGTGAGGTCCTCACGTGGGAGGAAGAGAACAAGGTGGTTAAGATAGAGAATCTGGAGAGGGTACCCCAATCACACTACAGTCGGGTGCTACTGGGTGGAGGAGAAAACCATCCTAACCCCACAGCACTGCAAAGACGCTCCTGTCCCGCCACACTCCCACCATCACGAACATCAGTAAGTCAGCAGTTTCAGATTCTGCCATTTCCTTCCCCATAAAAGCATGAAGATAGGGAGTCGGTGTCCTTACGCTTTATTTTTAGGGTATTTGGGAGTTTCCAGGATGTGAAGAAGTTAGGTGGAGGAAATTACGGCTTCAATTTTTTTCAGTTAACTACAGGACGCTTCATTCAGGCCGGGCACCATGTGCACAGTCTTAAGAAGCAGCAGGAACTGCATTTGCAAACACGTgttgtaaaaaattaattttaaaaaagctacctgtataaatataaatatatatatttaaagacaaggttttgatactttttttttaaaaaacaaaaactacaagaGAAGACTGTACAAACCACGGgcttttaaaatagcattttgcTCTCTACAAGCTGTTAATGtcaggggtgaggggtgagggacTGGTTTGCAAACACACTATCCAAATGGATTTGCTTGTTTTGTCAAGCCACCCTCCAAATTACCATATTTGGTGTAATAGTAGGGCATGTAAAGTTATTGGGTCCCATTAACCATTTCTGCTCTTGTCATGTCATTCCGGGTTCCGTTAGCTCCCGTACTCGGCAATCCAGCTTcttccagaggcagaggggctGAAGGAAGTGTGCTCCATTTCACTAGCTGTACTGACATCATCCACATGTGGACATTTGTAATATCAGTACACTATTTCTAGAGagattaaattcattttttaaaatc