| Gene Name | Mdh1 |
|
| Specie | Mus musculus | |
| Full Name | malate dehydrogenase 1, NAD (soluble) | |
| Also known as | B230377B03Rik|KAR|MDH-s|MDHA|Mor-2|Mor2 | |
| Coordinate | chr11:21506692-21521934 | |
| Strand | - | |
| Gene summary | This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. A pseudogene has been identified on chromosomes 12. [provided by RefSeq, Feb 2016] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| Mdh1P1 | chr12:100045976-100046645 | - |
Intergenic |
ENSMUSG00000112999 | UCSC |
| >NM_001316675.1 |
| GTTTAGCACTGTCAGGAATGCACGAAGGTGGGCGCCAGAGGTCGCCGGAAGAACTACACTTCCCAGAAAGGGCCGTGTCTCCAGCCGAACCTTTGCGGGCCAGCCCCGCGTTCTCTCCCAGAGTCTGTTCCGCTGTAGAGGTGACCTGACTGCTGGAGACTGCCTTTTGCAGGTGCAGAGATCGGCCTTGCAGTTTGCAATAATGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGTTGTACAGTATTGGAAATGGATCTGTCTTTGGGAAAGACCAGCCCATCATTCTTGTGCTGTTGGACATCACCCCCATGATGGGTGTTCTGGACGGTGTCCTGATGGAACTGCAAGACTGTGCCCTTCCCCTTCTGCAGGATGTCATTGCAACGGACAAAGAAGAGATTGCCTTCAAAGACCTGGATGTGGCTGTCCTAGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGGAAGGACCTACTGAAAGCCAATGTGAAAATCTTCAAATCCCAGGGCACAGCCTTGGAGAAATACGCCAAGAAATCAGTTAAGGTCATTGTTGTGGGAAACCCAGCCAATACGAACTGCCTGACAGCCTCCAAGTCAGCGCCATCGATCCCCAAGGAGAATTTCAGTTGCCTGACTCGCTTGGACCACAACCGAGCAAAATCTCAAATTGCTCTTAAACTCGGTGTAACCgctgatgatgtaaagaatgtcATTATCTGGGGAAATCATTCATCGACCCAGTATCCAGATGTCAATCATGCCAAGGTGAAACTGCAAGGAAAGGAAGTCGGTGTGTATGAAGCCCTGAAAGACGACAGCTGGCTGAAGGGAGAGTTCATCACGACTGTGCAACAGCGTGGTGCTGCTGTCATCAAGGCTCGGAAGCTGTCCAGTGCAATGTCTGCTGCGAAAGCCATCGCAGACCACATCAGAGACATCTGGTTTGGAACCCCAGAGGGAGAGTTCGTGTCGATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTCCCTGATGACCTGCTCTACTCATTCCCTGTCGTGATCAAGAATAAGACCTGGAAGTTTGTTGAAGGCCTCCCCATTAATGACTTCTCCCGTGAAAAGATGGACCTGACAGCAAAGGAGCTGACCGAGGAAAAGGAGACCGCTTTTGAGTTTCTCTCCTCTGCGTGACTAGACACTCGTTTTGACATCAGCAGACAGCCGAAGGCTGAGGAATCAAAATGTCGTCTTTGAGCCTAGTACCAAACAGTAATAATGCTACATTCAAATTGTGaacagcaaaatattttaaatagtgtGTGCTTTATGATTTGTGAAAGTCTATCATGTTGTTAGTGCTGCAATctaaataaaagtatattcaaGTGAAAATCTCTCAGACTCTGTTTCTACTTTATATTTAGTATCTTCAGGAAAACAAGTTTGCCCAATAgattataattttacttttttaattgactaaaagaaataaagatggaaaatATTATGAAGTAAAGCATTAGTCTCTAACATAAACAAGGAAGCCCAATCAATTTCAGAGGGATCCCATTACTTAAGTCCTTAAAGGTTGGTTCATGTTTTGCTcataatttgattttaaaattagcTGTAAGAAGGTTGCAGATAATCTATCTTCTTTATATTCTATAGCAGAATAATGAAGTCATTAATATTTGATAGCCAATAATACCACACTATTAATATTTGTAAGCTAAGATTATTAGAAACATAAAACTGTTTTTGAGTCAGTCTGTTTTCCATGAGAAGACATGCATcatctttgtgtgttttgtgcatTACTCAGTGCAATAAATAACCATAATCTCAAAGCTGGCTGTAATTTGCTTTGTGGATATTCAAATACTTGTTGGTTAGATTTGCTGTTTACCTGTATTAGTAAATATTATCTATATTAAAGTGC |