| Gene Name | DUSP8 |
|
| Specie | Homo sapiens | |
| Full Name | dual specificity phosphatase 8 | |
| Also known as | C11orf81|HB5|HVH-5|HVH8 | |
| Coordinate | chr11:1554051-1572839 | |
| Strand | - | |
| Gene summary | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| DUSP8P1 | chr10:47564030-47565576 | + |
Intragenic Intragenic |
ENSG00000215065 | UCSC |
| DUSP8P6 | chr10:46774859-46776405 | - |
Intergenic |
ENSG00000215097 | UCSC |
| DUSP8P5 | chr10:73731603-73735340 | + |
Intergenic |
ENSG00000235316 | UCSC |
| >NM_004420.3 |
| ACTCGCGGCCGAGCGCGGCGGCCGAGCCGGCTCCCCCCACGACGCCCCGCCGGACGCCGGACgcccgagcccgagcccgagcccgagcccgagccGCGCCGGAACCTCCCGGCCGCGCCCGCCGAGCCGCGGGGCTGGGATGCGCGCCGCGAGCGCGCGTGCCCGCCCGCAGTGCGCGCGCCCCGGCCCGAGCGAGCGCTCCCCGcggcgttggcggcggcgacggcggcgacggcgacgCGGCCCGCGCGCTCCCCCGGCCCCTGCCCCGGCTGCGCGGGCCCCCGCCGGGCCCATGGACGGCGCGGCCGAGCGGGCGCCCTGAGCGCGGCGCGGGTCCCCGGAGCGCCCCCGAGGCGAGCGCGAGCGAGGTCCAGCACCATGTGCTAGGTCACTCCCAGCGCGAGGCCACACCTGGGCCGTCGGAGCAGCCCCTCCTCACTTCAGGGGTCACCCTCCCCAGCACCCATTGCCCCACCATGGCTGGGGACCGGCTCCCGAGGAAGGTGATGGATGCCAAGAAGCTGGCCAGCCTGCTGCGGGGCGGGCCTGGGGGGCCGCTGGTCATCGACAGCCGCTCCTTCGTGGAGTACAACAGCTGGCATGTGCTCAGCTCCGTCAACATCTGCTGCTCCAAGCTGGTGAAGCGGCGGCTGCAGCAGGGCAAGGTGACCATTGCGGAGCTCATCCAGCCGGCTGCACGCAGCCAGGTGGAGGCTACGGAGCCACAGGACGTGGTGGTCTATGACCAGAGCACGCGGGACGCCAGCGTGCTGGCCGCAGACAGCTTCCTCTCCATCCTGCTGAGCAAGCTGGACGGCTGCTTCGACAGCGTGGCCATCCTCACTGGGGGCTTCGCCACCTTCTCCTCCTGCTTCCCCGGCCTCTGCGAGGGCAAGCCTGCTGCCCTGCTACCCATGAGCCTCTCCCAGCCCTGCCTGCCTGTGCCCAGCGTGGGCCTGACCCGCATCCTGCCTCACCTCTACCTGGGCTCGCAGAAGGACGTCCTAAACAAGGATCTGATGACGCAAAATGGAATAAGCTACGTCCTCAACGCCAGCAACTCCTGCCCCAAGCCTGACTTCATCTGCGAGAGCCGCTTCATGCGGGTCCCCATCAACGACAACTACTGTGAAAAACTGCTGCCCTGGCTGGACAAGTCCATCGAGTTCATCGATAAAGCCAAGCTCTCCAGCTGCCAAGTCATCGTCCACTGTCTGGCTGGCATCTCCCGCTCTGCCACCATCGCCATCGCCTACATCATGAAGACCATGGGCATGTCCTCCGACGACGCCTACAGGTTCGTGAAGGACAGGCGCCCGTCCATCTCGCCCAACTTCAACTTCCTGGGCCAGCTGCTGGAGTACGAGCGCAGCCTGAAGCTGCTGGCCGCCCTGCAGGGCGACCCGGGCACCCCCTCAGGGACGCCGGAGCCTCCGCCCAGTCCTGCCGCCGGGGCCCCGCTGCCACGGCTGCCACCACCTACCTCAGAGAGCGCTGCCACAGGGAATGCGGCTGCCAGGGAGGGCGGCCTGAGCGCGGGCGGGGAGCCCCCCGCGCCCCCCACGCCCCCGGCGACCAGCGCACTGCAGCAGGGCCTGCGCGGCCTGCACCTCTCCTCGGACCGCCTGCAGGACACTAACCGCCTCAAGCGCTCCTTCTCCCTGGACATCAAGTCTGCCTACGCCCCTAGCAGGCGGCCCGACGGCCCCGGGCCCCCCGACCCCGGCGAGGCCCCGAAGCTCTGCAAGCTGGACAGCCCGTCGGGGGCCGCGCTGGGCCTGTCCTCGCCCAGCCCGGACAGCCCGGACGCCGCGCCTGAGGCGCGCCCACGGCCCCGCCGGCGGCCCCGGCcccccgccggctcccccgcgcgctcccccgcgcACAGCCTCGGCCTGAACTTCGGCGATGCGGCCCGGCAGACTCCGcggcacggcctctcggccctgtcggcgcccgggctgcccggccctggccagccggccggccCCGGGGCCTGGGCACCGCCGCTCGACTCCCCAGGCACGCCGTCGCCCGACGGGCCCTGGTGCTTCAGCCCCGAGGGCGCACAGGGGGCGGGCGGGGTGCTGTTTGCGCCCTTCGGCCGGGCGGGCGCCCCGGGACCAggcggcggcagcgacctgcggcggcgggaggcagcgAGGGCTGAGCCCCGGGACGCGCGGACCGGCTGGCCCGAGGAGCCGGCCCCGGAGACGCAGTTCAAGCGCCGCAGCTGCCAGATGGAGTTCGAGGAGGGCATGGTGGAGGGGCGCGCGCGCGGCGAGGAGCTGGCCGCCCTGGGCAAGCAGGCGAGCTTCTCGGGCAGCGTGGAGGTCATCGAGGTGTCCTGACCCCTCCGCTGCCCTCGGCCCCGCCGCCCGCAGCCAGGCCCGTTATAAATGTATATTATATATAATGCAAAGAAAGGTAAATGGTTTTACTGGGATTTTTATCGAGAAGTAAATATTTCGATTTTTTATTTATTTAAGCTGTTCATTCTGGCAATGATTTGGCAACAGTGCGGGTGGTCCTCGAGCTCTATTTTTACTGTCTGGTATTTAAACTGAAACATACGTTTCTAAGCAATACGAGGCCACCTTCAGTCGCAAGCTGGGTGCCAGGCCTGGGGCCCCTCCCAGTTCCCCCGCCCCAGGAAACACTGCTGACCTTTGCAAAGGCTGCCGAGCTTTCGTGCACTTTTTACATAACAAAAAGGTGAAAAAAAGGAAAAAAAAACTTCTTTGCCACAAACTGAGCCGCAGAACCCCCCTTCTCCCCCCACCCACCTCCCCTGCTCCCTCCCTTCTCTGCGCCGGCCTAGGGCTCTGCACCAAAGCCATAGGATGGAGGAGCAGGAGCTGGTGTGCCCCGGAGAGGTGCGGCCAGCCCTCCATCAGCTCCAGGCACCAAATCTTGGTGGCAAGGAGGGCACCCCGCTGCCCGTTGCCCCAGAGCTGTTCTCTGGCAGGGGAGGACAGGCATTGGGCTTCATGGTGCCAGGGTGTTCAGAGGGGCTGAGAAATAGAACAGTGTGTGTAGGGGCTTCGGGCAGGGGGTTCTGGAACGTCAGATGAGGTGCAGCCCAGGGGAGGACAGAGGTGTTAGTGCCCCCAACTCCTGCCAGAGCCCCAGTCCAGCCACAGAGTGGCTCAGAAAGGCCATTCCTAGAGGGCTGCGGCCCTCCCTTCTCCCTTGCCCATGCCCCCAGAGCTGCCTGCCGGGCAGGGTGGCACCATTGCAGGAGAGGAGCTTGGCCTCCGGGGGTCAGGCAGGAGGCGCCTGGCTAGCCAGTGCTGGCTCCACTGGGCAGGAAGCCCTGGACCCCCAGGTATGAGGAGGGGGTGGTCTTAGGGTTCTGTTCCAGGTCTGCCCCGCCCCCCTCCCAGCCATGCCCCAGGCAGAACTTGGAATTCAGGTGTGCACCTGCAGGCTGAGGGGCTCTGTGAGCAGGTGCTGCTCACACAGGGAGTTCAGGCGCCAGCCAAGCCCCTGTGCTGCTGGGATAGGCCTGCTTCACTTAGGGAGCACTGCCTCAAGACAGGTAAAGCCCCCTCGTTTGCCCCCACCCCCATGGGGCCGCTCAGGAGAGAAACTCCCATTCACCCCTTTCCCAGGGTGCTCTCTCTCTAGGTGGCATGCCAGCCCCCAAACACAAGTGGCTTTTGGGCCCAGGTGGGTCAGCCTGCTGCCCCTGCCCCATACCCCCTCGGGCCATTGGGACCCCTGCCCTTCAGATGTCCTAGGGTCTAGGAGTGGGGCCAGTCACTGTGGGAAGAGGCCAGGGGCTTGGCCGGAGAGGCAGCCCAGGGCAGGACCCAGTCCTGAGTCCTGGAGCAGGGCCAGGGAGGCGCCCATCCCGCCCCAGCCAGCCGCCCTCTCTGCTGTTTCTTCTATTTGTTCTTCTTTTCACCCACAGCTCTGTGTTCCTGTCATCCCTCCTTTCAGCAAAAGTCCTGTTCCCGTTCCCTCTGTCCCCACCCACTCCTGTTCCCCCAAGAAAATAAGCTATCGTTGTATTTGCAATCTATGGATTAGAGGTTTAAGTATttattattattggttaattattattaattatGTAAATTTGCCTCCCATATGTCTGTTGCGTTGGGTTTCTGAGGAGACCCTGGGTGAGGAGGATGCACTGGCTTCCCGCTTCTCGCCCCCCACCCCTGTGCTGTCCGGGAGACAGTGGTCTGGGGCCACTGGTTGGGcccccttctcccttcccccttccccttgtcccttcTGCAGGCCGTTGAGGGGGGCTGTCTGTCTCAGTCTGTCTCTGCTCCCACTCTTGAGGCACTGGTTACCGCAAAGTGAGCAGCCAGCAGGGGGGCGAAGGTCCTGTGTTGGCCACTGCCTCCTCCAGTGCTGCAGGAGGCGGGCTGAGGCCCCACCTGGTGGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCTCCTCCAGTGCTGCGGGAGGCGGGCCAGGGCCCCACCTGGTGGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCTGGCATTGGGATCGCCCCAAAATGGACCCGGCCCCTCCTGTTATTTGCTGGGAAGTCCAGCGGAGGAGAGGGTGCAGGTCCCCCGCTGAGCCTCCAGTCTCTGTAGACTGGGCTGCCGGCCCTTCAGCCCCCCTTGGAGCCCCTCCCGCCACAGCCGCACCTTCTGCTCCCGGCCCCTCCCTTTGTATTTGGAGACAATGTGTTGTAATAAAGCTTAAAGTGGATGTTTTC |
| >NM_004420.3_2 |
| ACTCGCGGCCGAGCGCGGCGGCCGAGCCGGCTCCCCCCACGACGCCCCGCCGGACGCCGGACgcccgagcccgagcccgagcccgagcccgagccGCGCCGGAACCTCCCGGCCGCGCCCGCCGAGCCGCGGGGCTGGGATGCGCGCCGCGAGCGCGCGTGCCCGCCCGCAGTGCGCGCGCCCCGGCCCGAGCGAGCGCTCCCCGcggcgttggcggcggcgacggcggcgacggcgacgCGGCCCGCGCGCTCCCCCGGCCCCTGCCCCGGCTGCGCGGGCCCCCGCCGGGCCCATGGACGGCGCGGCCGAGCGGGCGCCCTGAGCGCGGCGCGGGTCCCCGGAGCGCCCCCGAGGCGAGCGCGAGCGAGGTCCAGCACCATGTGCTAGGTCACTCCCAGCGCGAGGCCACACCTGGGCCGTCGGAGCAGCCCCTCCTCACTTCAGGGGTCACCCTCCCCAGCACCCATTGCCCCACCATGGCTGGGGACCGGCTCCCGAGGAAGGTGATGGATGCCAAGAAGCTGGCCAGCCTGCTGCGGGGCGGGCCTGGGGGGCCGCTGGTCATCGACAGCCGCTCCTTCGTGGAGTACAACAGCTGGCATGTGCTCAGCTCCGTCAACATCTGCTGCTCCAAGCTGGTGAAGCGGCGGCTGCAGCAGGGCAAGGTGACCATTGCGGAGCTCATCCAGCCGGCTGCACGCAGCCAGGTGGAGGCTACGGAGCCACAGGACGTGGTGGTCTATGACCAGAGCACGCGGGACGCCAGCGTGCTGGCCGCAGACAGCTTCCTCTCCATCCTGCTGAGCAAGCTGGACGGCTGCTTCGACAGCGTGGCCATCCTCACTGGGGGCTTCGCCACCTTCTCCTCCTGCTTCCCCGGCCTCTGCGAGGGCAAGCCTGCTGCCCTGCTACCCATGAGCCTCTCCCAGCCCTGCCTGCCTGTGCCCAGCGTGGGCCTGACCCGCATCCTGCCTCACCTCTACCTGGGCTCGCAGAAGGACGTCCTAAACAAGGATCTGATGACGCAAAATGGAATAAGCTACGTCCTCAACGCCAGCAACTCCTGCCCCAAGCCTGACTTCATCTGCGAGAGCCGCTTCATGCGGGTCCCCATCAACGACAACTACTGTGAAAAACTGCTGCCCTGGCTGGACAAGTCCATCGAGTTCATCGATAAAGCCAAGCTCTCCAGCTGCCAAGTCATCGTCCACTGTCTGGCTGGCATCTCCCGCTCTGCCACCATCGCCATCGCCTACATCATGAAGACCATGGGCATGTCCTCCGACGACGCCTACAGGTTCGTGAAGGACAGGCGCCCGTCCATCTCGCCCAACTTCAACTTCCTGGGCCAGCTGCTGGAGTACGAGCGCAGCCTGAAGCTGCTGGCCGCCCTGCAGGGCGACCCGGGCACCCCCTCAGGGACGCCGGAGCCTCCGCCCAGTCCTGCCGCCGGGGCCCCGCTGCCACGGCTGCCACCACCTACCTCAGAGAGCGCTGCCACAGGGAATGCGGCTGCCAGGGAGGGCGGCCTGAGCGCGGGCGGGGAGCCCCCCGCGCCCCCCACGCCCCCGGCGACCAGCGCACTGCAGCAGGGCCTGCGCGGCCTGCACCTCTCCTCGGACCGCCTGCAGGACACTAACCGCCTCAAGCGCTCCTTCTCCCTGGACATCAAGTCTGCCTACGCCCCTAGCAGGCGGCCCGACGGCCCCGGGCCCCCCGACCCCGGCGAGGCCCCGAAGCTCTGCAAGCTGGACAGCCCGTCGGGGGCCGCGCTGGGCCTGTCCTCGCCCAGCCCGGACAGCCCGGACGCCGCGCCTGAGGCGCGCCCACGGCCCCGCCGGCGGCCCCGGCcccccgccggctcccccgcgcgctcccccgcgcACAGCCTCGGCCTGAACTTCGGCGATGCGGCCCGGCAGACTCCGcggcacggcctctcggccctgtcggcgcccgggctgcccggccctggccagccggccggccCCGGGGCCTGGGCACCGCCGCTCGACTCCCCAGGCACGCCGTCGCCCGACGGGCCCTGGTGCTTCAGCCCCGAGGGCGCACAGGGGGCGGGCGGGGTGCTGTTTGCGCCCTTCGGCCGGGCGGGCGCCCCGGGACCAggcggcggcagcgacctgcggcggcgggaggcagcgAGGGCTGAGCCCCGGGACGCGCGGACCGGCTGGCCCGAGGAGCCGGCCCCGGAGACGCAGTTCAAGCGCCGCAGCTGCCAGATGGAGTTCGAGGAGGGCATGGTGGAGGGGCGCGCGCGCGGCGAGGAGCTGGCCGCCCTGGGCAAGCAGGCGAGCTTCTCGGGCAGCGTGGAGGTCATCGAGGTGTCCTGACCCCTCCGCTGCCCTCGGCCCCGCCGCCCGCAGCCAGGCCCGTTATAAATGTATATTATATATAATGCAAAGAAAGGTAAATGGTTTTACTGGGATTTTTATCGAGAAGTAAATATTTCGATTTTTTATTTATTTAAGCTGTTCATTCTGGCAATGATTTGGCAACAGTGCGGGTGGTCCTCGAGCTCTATTTTTACTGTCTGGTATTTAAACTGAAACATACGTTTCTAAGCAATACGAGGCCACCTTCAGTCGCAAGCTGGGTGCCAGGCCTGGGGCCCCTCCCAGTTCCCCCGCCCCAGGAAACACTGCTGACCTTTGCAAAGGCTGCCGAGCTTTCGTGCACTTTTTACATAACAAAAAGGTGAAAAAAAGGAAAAAAAAACTTCTTTGCCACAAACTGAGCCGCAGAACCCCCCTTCTCCCCCCACCCACCTCCCCTGCTCCCTCCCTTCTCTGCGCCGGCCTAGGGCTCTGCACCAAAGCCATAGGATGGAGGAGCAGGAGCTGGTGTGCCCCGGAGAGGTGCGGCCAGCCCTCCATCAGCTCCAGGCACCAAATCTTGGTGGCAAGGAGGGCACCCCGCTGCCCGTTGCCCCAGAGCTGTTCTCTGGCAGGGGAGGACAGGCATTGGGCTTCATGGTGCCAGGGTGTTCAGAGGGGCTGAGAAATAGAACAGTGTGTGTAGGGGCTTCGGGCAGGGGGTTCTGGAACGTCAGATGAGGTGCAGCCCAGGGGAGGACAGAGGTGTTAGTGCCCCCAACTCCTGCCAGAGCCCCAGTCCAGCCACAGAGTGGCTCAGAAAGGCCATTCCTAGAGGGCTGCGGCCCTCCCTTCTCCCTTGCCCATGCCCCCAGAGCTGCCTGCCGGGCAGGGTGGCACCATTGCAGGAGAGGAGCTTGGCCTCCGGGGGTCAGGCAGGAGGCGCCTGGCTAGCCAGTGCTGGCTCCACTGGGCAGGAAGCCCTGGACCCCCAGGTATGAGGAGGGGGTGGTCTTAGGGTTCTGTTCCAGGTCTGCCCCGCCCCCCTCCCAGCCATGCCCCAGGCAGAACTTGGAATTCAGGTGTGCACCTGCAGGCTGAGGGGCTCTGTGAGCAGGTGCTGCTCACACAGGGAGTTCAGGCGCCAGCCAAGCCCCTGTGCTGCTGGGATAGGCCTGCTTCACTTAGGGAGCACTGCCTCAAGACAGGTAAAGCCCCCTCGTTTGCCCCCACCCCCATGGGGCCGCTCAGGAGAGAAACTCCCATTCACCCCTTTCCCAGGGTGCTCTCTCTCTAGGTGGCATGCCAGCCCCCAAACACAAGTGGCTTTTGGGCCCAGGTGGGTCAGCCTGCTGCCCCTGCCCCATACCCCCTCGGGCCATTGGGACCCCTGCCCTTCAGATGTCCTAGGGTCTAGGAGTGGGGCCAGTCACTGTGGGAAGAGGCCAGGGGCTTGGCCGGAGAGGCAGCCCAGGGCAGGACCCAGTCCTGAGTCCTGGAGCAGGGCCAGGGAGGCGCCCATCCCGCCCCGGCCAGCCGCCCTCTCTGCTGTTTCTTCTATTTGTTCTTCTTTTCACCCACAGCTCTGTGTTCCTGTCATCCCTCCTTTCAGCAAAAGTCCTGTTCCCGTTCCCTCTGTCCCCACCCACTCCTGTTCCCCCAAGAAAATAAGCTATCGTTGTATTTGCAATCTATGGATTAGAGGTTTAAGTATttattattattggttaattattattaattatGTAAATTTGCCTCCCATATGTCTGTTGCGTTGGGTTTCTGAGGAGACCCTGGGTGAGGAGGATGCACTGGCTTCCCGCTTCTCGCCCCCCACCCCTGTGCTGTCCGGGAGACAGTGGTCTGGGGCCACTGGTTGGGcccccttctcccttcccccttccccttgtcccttcTGCAGGCCGTTGAGGGGGGCTGTCTGTCTCAGTCTGTCTCTGCTCCCACTCTTGAGGCACTGGTTACCGCAAAGTGAGCAGCCAGCAGGGGGGCGAAGGTCCTGTGTTGGCCACTGCCTCCTCCAGTGCTGCAGGAGGCGGGCTGAGGCCCCACCTGGTGGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCTCCTCCAGTGCTGCGGGAGGCGGGCCAGGGCCCCACCTGGTGGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCTGGCATTGGGATCGCCCCAAAATGGACCCGGCCCCTCCTGTTATTTGCTGGGAAGTCCAGCGGAGGAGAGGGTGCAGGTCCCCCGCTGAGCCTCCAGTCTCTGTAGACTGGGCTGCCGGCCCTTCAGCCCCCCTTGGAGCCCCTCCCGCCACAGCCGCACCTTCTGCTCCCGGCCCCTCCCTTTGTATTTGGAGACAATGTGTTGTAATAAAGCTTAAAGTGGATGTTTTC |