Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DUSP8P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:47564030-47565576  UCSC
Coordinates (T2T) chr10:48455329-48456875  UCSC
Coordinates (hg19) chr10:48962956-48964502  UCSC
Strand +
Parental Sequence NM_004420.3
Parental seq. overlap 1406 bp
Parental seq. overlap (%) 29%
Genomic Region Intragenic (ANXA8)
Intragenic (ANXA8L1)
Retrocopy Summary DUSP8P1, located on chr10:47564030-47565576, is a retrocopy of the parental gene DUSP8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DUSP8
Full Name dual specificity phosphatase 8
Also known as C11orf81|HB5|HVH-5|HVH8
Coordinate chr11:1554051-1572839
Strand -
Gene summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DUSP8P1
Bonobo Pan paniscus DUSP8P1
Orangutan Pongo abelii DUSP8P1
Gorilla Gorilla gorilla Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DUSP8P1
GCCCCAGCCCCCGCCCCAGCTGCGCGGGCCCCCGCCTGGCCCATGGACTGCACAGCCGAGCGGGCGCCTTGAGCGCGGTGCGGGTCCTCGGAGCACCCCCGAGGTGAGCGCAAGCAAGGTCCGGCATCATGTGCTAGGTTATTCCCAGTGCGAGGCCACACTTGGGCCGTCGGAGCAGCCCCTCCTCACTTCAGGGGTCACCCTCCCCAAGACCCATTGCCCCATCATGGCCGGGGACCGGCTCCCCAGGAAGGTGATGGACGCCAAGAAGCTGGCCAGCCTGCTGCGGGGCGGGCCTGGGGGGGCCTGGTCATCGACAGTCACTCCTTCCTGGAGTACAACAGCTGGCATGTGCTCAGCTCCGTCAACATCTGCTGCTCCAAGCTGGTGAAGTGGCGGTTGCAGAAGGGCAAGGTGACCATTGTGGAGTTCATCCAGCCGGCCGCACGCAGCCAGGTGGAGGCCACTGAGCCACAGGACGTGGTGGTCTATGACCAGAGCACGCGGCCGCAGACAGCTTCCTCTCCATCCTGCTGACCAAGCTGGATGGCTGCTTCCACAGCGTGGCCGGCTGCTTCCACAGCATGGCCATCATCACGGGGGGCTTCGCCACCTTCTCCTCCTGCTTCCCCGACCTCTGCAAGGGTGAGCCTGCTGCCCTGCTACCCATGAGCCTCTCCCAGTCCTGCCTGCTCGTGCCCAGCGTGGGCCTGACCCTCATCCTGCCTCACCTCTACCTGGGCTCGCAGGAAGACGTCCTGAACAAGGATCTGATGACGCAGAATGGAATAAGCTACGTCCTCTATGCCAGCAACTCCTGCCCCAAGCCTGACTTCATCTACCAGAGCCACTTCTTGCGGGTCCCCATCAACGACAACTACTGTGAAAAGCTGCTGCCCTGGCTGGACAAGTCCATCGAGTTCGTCGATAAAGCCAAGCTGTCCAGCTGCCAAGTCATCGTCCACCGTCTGGCCGGCATCTCCTGCTGTGCCACTATCGCCATCGCCTACATCATGAAGACCATGGGCATGTCCTCCGAAGACGCCTACAGGTTTGTGAAGGACCAGCGCCCGTCCATCTCGCCCAACTTCAACTTCCTGGGCCAGCTGCTGGAGGACCAGAGCAGCCCGAAGCTGCTGGCCGCCGTGCAGGGCGACGCGGGCACCCCCTCAGGAATGCAGGAGCCTCCCCCCAGCCCTGCGGCCGGGGCCCCACTGCCATGGCTGCCACCACCTACCTCAGAGACCGCTGCCACCAGGAGTGCAGCTGCCAGGGAGGGCGGCCCGAGCGCGGGCAGGAAGCCCCCGGCGCCCCCCACGGCCACCAGCACGCTGCAGCAGGGCCTGCGCAGCCTGCGCCTCTCCTCGGACCACCTGCAGGACACCAGCCGCCTCAAGCCCTCCTTCTCTCTGGACATCAAGTCGGCCTACGCCCCCAGCAGGCGGCCCGGCGGCCCGGGCCCAGCGACCCCGGCGAGGCCCCGAAGCTCTCTGAAAGCTGGACAGCCAGTCGGGGCCATGCTGGGCCTGCCCTCGCCCTGCCCGGAC
>NM_004420.3
ACTCGCGGCCGAGCGCGGCGGCCGAGCCGGCTCCCCCCACGACGCCCCGCCGGACGCCGGACgcccgagcccgagcccgagcccgagcccgagccGCGCCGGAACCTCCCGGCCGCGCCCGCCGAGCCGCGGGGCTGGGATGCGCGCCGCGAGCGCGCGTGCCCGCCCGCAGTGCGCGCGCCCCGGCCCGAGCGAGCGCTCCCCGcggcgttggcggcggcgacggcggcgacggcgacgCGGCCCGCGCGCTCCCCCGGCCCCTGCCCCGGCTGCGCGGGCCCCCGCCGGGCCCATGGACGGCGCGGCCGAGCGGGCGCCCTGAGCGCGGCGCGGGTCCCCGGAGCGCCCCCGAGGCGAGCGCGAGCGAGGTCCAGCACCATGTGCTAGGTCACTCCCAGCGCGAGGCCACACCTGGGCCGTCGGAGCAGCCCCTCCTCACTTCAGGGGTCACCCTCCCCAGCACCCATTGCCCCACCATGGCTGGGGACCGGCTCCCGAGGAAGGTGATGGATGCCAAGAAGCTGGCCAGCCTGCTGCGGGGCGGGCCTGGGGGGCCGCTGGTCATCGACAGCCGCTCCTTCGTGGAGTACAACAGCTGGCATGTGCTCAGCTCCGTCAACATCTGCTGCTCCAAGCTGGTGAAGCGGCGGCTGCAGCAGGGCAAGGTGACCATTGCGGAGCTCATCCAGCCGGCTGCACGCAGCCAGGTGGAGGCTACGGAGCCACAGGACGTGGTGGTCTATGACCAGAGCACGCGGGACGCCAGCGTGCTGGCCGCAGACAGCTTCCTCTCCATCCTGCTGAGCAAGCTGGACGGCTGCTTCGACAGCGTGGCCATCCTCACTGGGGGCTTCGCCACCTTCTCCTCCTGCTTCCCCGGCCTCTGCGAGGGCAAGCCTGCTGCCCTGCTACCCATGAGCCTCTCCCAGCCCTGCCTGCCTGTGCCCAGCGTGGGCCTGACCCGCATCCTGCCTCACCTCTACCTGGGCTCGCAGAAGGACGTCCTAAACAAGGATCTGATGACGCAAAATGGAATAAGCTACGTCCTCAACGCCAGCAACTCCTGCCCCAAGCCTGACTTCATCTGCGAGAGCCGCTTCATGCGGGTCCCCATCAACGACAACTACTGTGAAAAACTGCTGCCCTGGCTGGACAAGTCCATCGAGTTCATCGATAAAGCCAAGCTCTCCAGCTGCCAAGTCATCGTCCACTGTCTGGCTGGCATCTCCCGCTCTGCCACCATCGCCATCGCCTACATCATGAAGACCATGGGCATGTCCTCCGACGACGCCTACAGGTTCGTGAAGGACAGGCGCCCGTCCATCTCGCCCAACTTCAACTTCCTGGGCCAGCTGCTGGAGTACGAGCGCAGCCTGAAGCTGCTGGCCGCCCTGCAGGGCGACCCGGGCACCCCCTCAGGGACGCCGGAGCCTCCGCCCAGTCCTGCCGCCGGGGCCCCGCTGCCACGGCTGCCACCACCTACCTCAGAGAGCGCTGCCACAGGGAATGCGGCTGCCAGGGAGGGCGGCCTGAGCGCGGGCGGGGAGCCCCCCGCGCCCCCCACGCCCCCGGCGACCAGCGCACTGCAGCAGGGCCTGCGCGGCCTGCACCTCTCCTCGGACCGCCTGCAGGACACTAACCGCCTCAAGCGCTCCTTCTCCCTGGACATCAAGTCTGCCTACGCCCCTAGCAGGCGGCCCGACGGCCCCGGGCCCCCCGACCCCGGCGAGGCCCCGAAGCTCTGCAAGCTGGACAGCCCGTCGGGGGCCGCGCTGGGCCTGTCCTCGCCCAGCCCGGACAGCCCGGACGCCGCGCCTGAGGCGCGCCCACGGCCCCGCCGGCGGCCCCGGCcccccgccggctcccccgcgcgctcccccgcgcACAGCCTCGGCCTGAACTTCGGCGATGCGGCCCGGCAGACTCCGcggcacggcctctcggccctgtcggcgcccgggctgcccggccctggccagccggccggccCCGGGGCCTGGGCACCGCCGCTCGACTCCCCAGGCACGCCGTCGCCCGACGGGCCCTGGTGCTTCAGCCCCGAGGGCGCACAGGGGGCGGGCGGGGTGCTGTTTGCGCCCTTCGGCCGGGCGGGCGCCCCGGGACCAggcggcggcagcgacctgcggcggcgggaggcagcgAGGGCTGAGCCCCGGGACGCGCGGACCGGCTGGCCCGAGGAGCCGGCCCCGGAGACGCAGTTCAAGCGCCGCAGCTGCCAGATGGAGTTCGAGGAGGGCATGGTGGAGGGGCGCGCGCGCGGCGAGGAGCTGGCCGCCCTGGGCAAGCAGGCGAGCTTCTCGGGCAGCGTGGAGGTCATCGAGGTGTCCTGACCCCTCCGCTGCCCTCGGCCCCGCCGCCCGCAGCCAGGCCCGTTATAAATGTATATTATATATAATGCAAAGAAAGGTAAATGGTTTTACTGGGATTTTTATCGAGAAGTAAATATTTCGATTTTTTATTTATTTAAGCTGTTCATTCTGGCAATGATTTGGCAACAGTGCGGGTGGTCCTCGAGCTCTATTTTTACTGTCTGGTATTTAAACTGAAACATACGTTTCTAAGCAATACGAGGCCACCTTCAGTCGCAAGCTGGGTGCCAGGCCTGGGGCCCCTCCCAGTTCCCCCGCCCCAGGAAACACTGCTGACCTTTGCAAAGGCTGCCGAGCTTTCGTGCACTTTTTACATAACAAAAAGGTGAAAAAAAGGAAAAAAAAACTTCTTTGCCACAAACTGAGCCGCAGAACCCCCCTTCTCCCCCCACCCACCTCCCCTGCTCCCTCCCTTCTCTGCGCCGGCCTAGGGCTCTGCACCAAAGCCATAGGATGGAGGAGCAGGAGCTGGTGTGCCCCGGAGAGGTGCGGCCAGCCCTCCATCAGCTCCAGGCACCAAATCTTGGTGGCAAGGAGGGCACCCCGCTGCCCGTTGCCCCAGAGCTGTTCTCTGGCAGGGGAGGACAGGCATTGGGCTTCATGGTGCCAGGGTGTTCAGAGGGGCTGAGAAATAGAACAGTGTGTGTAGGGGCTTCGGGCAGGGGGTTCTGGAACGTCAGATGAGGTGCAGCCCAGGGGAGGACAGAGGTGTTAGTGCCCCCAACTCCTGCCAGAGCCCCAGTCCAGCCACAGAGTGGCTCAGAAAGGCCATTCCTAGAGGGCTGCGGCCCTCCCTTCTCCCTTGCCCATGCCCCCAGAGCTGCCTGCCGGGCAGGGTGGCACCATTGCAGGAGAGGAGCTTGGCCTCCGGGGGTCAGGCAGGAGGCGCCTGGCTAGCCAGTGCTGGCTCCACTGGGCAGGAAGCCCTGGACCCCCAGGTATGAGGAGGGGGTGGTCTTAGGGTTCTGTTCCAGGTCTGCCCCGCCCCCCTCCCAGCCATGCCCCAGGCAGAACTTGGAATTCAGGTGTGCACCTGCAGGCTGAGGGGCTCTGTGAGCAGGTGCTGCTCACACAGGGAGTTCAGGCGCCAGCCAAGCCCCTGTGCTGCTGGGATAGGCCTGCTTCACTTAGGGAGCACTGCCTCAAGACAGGTAAAGCCCCCTCGTTTGCCCCCACCCCCATGGGGCCGCTCAGGAGAGAAACTCCCATTCACCCCTTTCCCAGGGTGCTCTCTCTCTAGGTGGCATGCCAGCCCCCAAACACAAGTGGCTTTTGGGCCCAGGTGGGTCAGCCTGCTGCCCCTGCCCCATACCCCCTCGGGCCATTGGGACCCCTGCCCTTCAGATGTCCTAGGGTCTAGGAGTGGGGCCAGTCACTGTGGGAAGAGGCCAGGGGCTTGGCCGGAGAGGCAGCCCAGGGCAGGACCCAGTCCTGAGTCCTGGAGCAGGGCCAGGGAGGCGCCCATCCCGCCCCAGCCAGCCGCCCTCTCTGCTGTTTCTTCTATTTGTTCTTCTTTTCACCCACAGCTCTGTGTTCCTGTCATCCCTCCTTTCAGCAAAAGTCCTGTTCCCGTTCCCTCTGTCCCCACCCACTCCTGTTCCCCCAAGAAAATAAGCTATCGTTGTATTTGCAATCTATGGATTAGAGGTTTAAGTATttattattattggttaattattattaattatGTAAATTTGCCTCCCATATGTCTGTTGCGTTGGGTTTCTGAGGAGACCCTGGGTGAGGAGGATGCACTGGCTTCCCGCTTCTCGCCCCCCACCCCTGTGCTGTCCGGGAGACAGTGGTCTGGGGCCACTGGTTGGGcccccttctcccttcccccttccccttgtcccttcTGCAGGCCGTTGAGGGGGGCTGTCTGTCTCAGTCTGTCTCTGCTCCCACTCTTGAGGCACTGGTTACCGCAAAGTGAGCAGCCAGCAGGGGGGCGAAGGTCCTGTGTTGGCCACTGCCTCCTCCAGTGCTGCAGGAGGCGGGCTGAGGCCCCACCTGGTGGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCTCCTCCAGTGCTGCGGGAGGCGGGCCAGGGCCCCACCTGGTGGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCTGGCATTGGGATCGCCCCAAAATGGACCCGGCCCCTCCTGTTATTTGCTGGGAAGTCCAGCGGAGGAGAGGGTGCAGGTCCCCCGCTGAGCCTCCAGTCTCTGTAGACTGGGCTGCCGGCCCTTCAGCCCCCCTTGGAGCCCCTCCCGCCACAGCCGCACCTTCTGCTCCCGGCCCCTCCCTTTGTATTTGGAGACAATGTGTTGTAATAAAGCTTAAAGTGGATGTTTTC

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