| Gene Name | Pea15a |
|
| Specie | Mus musculus | |
| Full Name | proliferation and apoptosis adaptor protein 15A | |
| Also known as | Mat1|PEA-15|Pea15|Pkcs15 | |
| Coordinate | chr1:172024295-172034371 | |
| Strand | - | |
| Gene summary | This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| Pea15aP2 | chr12:49545799-49546260 | + |
Intergenic |
ENSMUSG00000112079 | UCSC |
| Pea15aP1 | chr5:77658995-77659358 | - |
Intergenic |
ENSMUSG00000047652 | UCSC |
| >NM_001329869.1 |
| gccccccgcccctccccggCTCTGACATCACCGGCCAGTCGGGTGGGGTGAGGCGGTGCTGGGCTCAAGCTCTGCTCCACGGGCGGAAGAGGCGGCGGCGGCAGGATCGGCGGCAGCGGTGGCAGGAGCCAAGGAGCAGGCTCCAGACGCTGCTTAGGAACCGGGGACCCGGGAGTGCCCGCACCCTGAGCTCTCAGCTCCGGAGGCGGtgagaggggcagagggaagatGTGTCGTGGGGAGGAGtCATGGCAGAGTACGGAACTCTCCTTCAGGACCTGACCAACAACATCACCCTTGAAGATCTGGAACAGCTCAAGTCAGCCTGCAAGGAGGACATCCCCAGTGAGAAGAGTGAGGAGATCACCACAGGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGACAAAGACAACCTCTCCTACATTGAGCACATCTTTGAGATATCTCGCCGTCCTGACCTCCTCACTATGGTGGTTGACTACAGAACCCGTGTGCTGAAGATCtctgaggaggaggagctggacaCCAAGCTAACCCGTATTCCCAGTGCCAAGAAGTACAAAGacattaTCCGGCAGCCCTCTGAAGAAGAAATCATCAAATTGGCTCCCCCACCAAAGAAGGCCTGAacaagggggaggaagaggaggaaggttgGATCTTCATCAGACCACTCCCTTCCCCATCCTCAATGGGAGGGGCTAGGGCAACCCCCTGCTCCGTACCCATTTACTAACTTGGTCCTAACCCTTActatgcgcgtgtgtgtgcgtgtgcgcacgctctggctgtctgtctgtctagctcATCTAGTTCCTCCTCCTCATGAGGGGATTGGAGGCAAGGGAGGGGGGGCTTAAATCCCCCCACTATAGGGGGAGGTGGACGCTTTTTCTATGTAAACAGAAATTGGcacattcctcctccttctcccctttcctccacTCTTCCCCCACATCTTTATGGAAGCAGAAAGGACCTGCATTTTCCTACACTGAGGAGCTATGGTGAAGATGAGGTATGGGAGAGATGGTTGTATCTAAAGAAAACCAGTGGGGAAGGAAGGTAAAGAGGCCACTCAACCTCCACCTGGTAAGGGACAAAGAAAAGCCAGGACTCAGTGTTTGTATCTCTATGCTGGACTGGTTAGAAGCCAGCTTCCTGCTGTTCCCTTAGGCTGAGGTCCTGAGTGCCAATGGGCCCTCCTTATGCCCTTGTTATGGGCCTGGGATGCGGATGAGCCAGAAATCTTAATGAGAAGACCACTCGATCCTTTCCTGGTCCCAAAGATCaaaccccaatggagaagccagCATTTACTGTCCCCCAACCTTCTGCTCTGGAGAGACGATGCCGGGACCATGCACTACTGAGCCTGAGCTAGGGacgcaggcagagacaggcccaCTTTCTGCTCCTCAGTTTCTAAATACAGACTGTTGGATAAACTgacctggagcctagggagaTTGGGGGATGAGATCCTTAGGTTTTAACCCCAACCTGCCCACAACCTACAGAGTATTGTAGGCAACCTTTCCACTCTCCAGTTTAGAATTCTCCAAGCAAGTAGTTAATTACAGTGTTTCCTTTGCACTGACCACCACCCTGATTCAATCCAGGAAGGGACTGGTAACCTTTCTCATTTGGGTTTGTGGATGCCACACAGTCAAGTCACTAGAGTGCAGTGAGTGAACCCAGCCTCCTCCCTGTCCCAAGATGCCCTTCCCCATCTTGACCGTGCTaactgtgtgtacatatatattctacatatatgtatattaaaccCGCACTGCCATGTCTGCCCTTTTTTGTGGTTTTTAGCATTAACTTATTGTCTAGGCCAGAGCGGGAGTGGGAGGGGATGCCACAGAAAGGAAGTGGCAGAGCCAAATTGTTACAGAGTCCAAACAGAAAAGAACACATTTCAACTAACCACAACAAATGTTACATTTACATGTGAGCTAAGAGACAATTTAGAGAAAGATGAAGGTAGGTGCTTTTAGGATGTGGGAGCAAAACTTCACAGGGAGGGGAGGAATGGCTGTCAGAAGAGGGTTCTTGAAGCCAGACTGACTAGAGCACCCTCAGTTCCTAGCTGAGCCCAGATTGCCCATCTCCTCTGGCCACTGCTGCAGACACCTGCCTTAACTCTCACACCTCGAAGACTCCAGCTTTGCCTTAAAGGTCCTTCCTAAATCTCCCTAGTCTTGCCTGGCATCTCCTTTAAGACAAGAAATCCTTGTACAACTGGGTGGGAGAAAGGAACTCTGGGTAACATCCTTCCTTCTGGGGTGTTCCATGGGAGCAGGAGTGAGACGGCGCTTCCCTTAtggaagagggaggagacaggGTGCTTCTCAGAAGCttctctgtaaggcaaaaacCAAACTTTAAACAGACTAACCTGCCCTAATATACTCACCCCCTCGTGCTGCTGTGAGGTTGCTCCTAGCCTGTGCTCCTCTGTCTGCAGCGTGCACAGCCTTGTTCTAACCCTGGAATAAAGGTGACTGACTCTACCGTA |