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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Pea15aP2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr12:49545799-49546260  UCSC
Strand +
Parental Sequence NM_001329869.1
Parental seq. overlap 389 bp
Parental seq. overlap (%) 15.3%
Genomic Region Intergenic
Retrocopy Summary Pea15aP2, located on chr12:49545799-49546260, is a retrocopy of the parental gene Pea15a. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Pea15a
Full Name proliferation and apoptosis adaptor protein 15A
Also known as Mat1|PEA-15|Pea15|Pkcs15
Coordinate chr1:172024295-172034371
Strand -
Gene summary This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Pea15P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Pea15aP2
AAACATCACCCTTGAAGACCTGGAACAGCTCAAGTCAGCCTGCAAGGAGGATATTCCCAGCAAAAACAGTGAGGCAATCACTACAGAGAGTGCCCAATTTAACTTCCCGCAGAGTCAAAGCAAGCTAGACAAAGACAACATCTCTTACATTGAGCACATCTTCAGATGTCTCCCCGTTCTGACCTACTCAGATAGTGGTTGACTACTGAGTCCGGGTGCTGAAGATCCCTAAGGAGAATAAACTGCACACCAAGCTAACCAGAATCTTCAGAGCTAAGGAGTACGAAGACAGTATCTGTCAGCCCTCTGAGGAAGAAATCATCAAATTGGCTCCTCCACCAAAGAAGTCCTGAAcaatggggaggaagaggaggaaggttgGATTTTTATCAGACCACTTCTTTCATTCAAAGGGAAGACCTAGGGCAACACCCTGCCCTGTACCTACTTACTAACTaggtc
>NM_001329869.1
gccccccgcccctccccggCTCTGACATCACCGGCCAGTCGGGTGGGGTGAGGCGGTGCTGGGCTCAAGCTCTGCTCCACGGGCGGAAGAGGCGGCGGCGGCAGGATCGGCGGCAGCGGTGGCAGGAGCCAAGGAGCAGGCTCCAGACGCTGCTTAGGAACCGGGGACCCGGGAGTGCCCGCACCCTGAGCTCTCAGCTCCGGAGGCGGtgagaggggcagagggaagatGTGTCGTGGGGAGGAGtCATGGCAGAGTACGGAACTCTCCTTCAGGACCTGACCAACAACATCACCCTTGAAGATCTGGAACAGCTCAAGTCAGCCTGCAAGGAGGACATCCCCAGTGAGAAGAGTGAGGAGATCACCACAGGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGACAAAGACAACCTCTCCTACATTGAGCACATCTTTGAGATATCTCGCCGTCCTGACCTCCTCACTATGGTGGTTGACTACAGAACCCGTGTGCTGAAGATCtctgaggaggaggagctggacaCCAAGCTAACCCGTATTCCCAGTGCCAAGAAGTACAAAGacattaTCCGGCAGCCCTCTGAAGAAGAAATCATCAAATTGGCTCCCCCACCAAAGAAGGCCTGAacaagggggaggaagaggaggaaggttgGATCTTCATCAGACCACTCCCTTCCCCATCCTCAATGGGAGGGGCTAGGGCAACCCCCTGCTCCGTACCCATTTACTAACTTGGTCCTAACCCTTActatgcgcgtgtgtgtgcgtgtgcgcacgctctggctgtctgtctgtctagctcATCTAGTTCCTCCTCCTCATGAGGGGATTGGAGGCAAGGGAGGGGGGGCTTAAATCCCCCCACTATAGGGGGAGGTGGACGCTTTTTCTATGTAAACAGAAATTGGcacattcctcctccttctcccctttcctccacTCTTCCCCCACATCTTTATGGAAGCAGAAAGGACCTGCATTTTCCTACACTGAGGAGCTATGGTGAAGATGAGGTATGGGAGAGATGGTTGTATCTAAAGAAAACCAGTGGGGAAGGAAGGTAAAGAGGCCACTCAACCTCCACCTGGTAAGGGACAAAGAAAAGCCAGGACTCAGTGTTTGTATCTCTATGCTGGACTGGTTAGAAGCCAGCTTCCTGCTGTTCCCTTAGGCTGAGGTCCTGAGTGCCAATGGGCCCTCCTTATGCCCTTGTTATGGGCCTGGGATGCGGATGAGCCAGAAATCTTAATGAGAAGACCACTCGATCCTTTCCTGGTCCCAAAGATCaaaccccaatggagaagccagCATTTACTGTCCCCCAACCTTCTGCTCTGGAGAGACGATGCCGGGACCATGCACTACTGAGCCTGAGCTAGGGacgcaggcagagacaggcccaCTTTCTGCTCCTCAGTTTCTAAATACAGACTGTTGGATAAACTgacctggagcctagggagaTTGGGGGATGAGATCCTTAGGTTTTAACCCCAACCTGCCCACAACCTACAGAGTATTGTAGGCAACCTTTCCACTCTCCAGTTTAGAATTCTCCAAGCAAGTAGTTAATTACAGTGTTTCCTTTGCACTGACCACCACCCTGATTCAATCCAGGAAGGGACTGGTAACCTTTCTCATTTGGGTTTGTGGATGCCACACAGTCAAGTCACTAGAGTGCAGTGAGTGAACCCAGCCTCCTCCCTGTCCCAAGATGCCCTTCCCCATCTTGACCGTGCTaactgtgtgtacatatatattctacatatatgtatattaaaccCGCACTGCCATGTCTGCCCTTTTTTGTGGTTTTTAGCATTAACTTATTGTCTAGGCCAGAGCGGGAGTGGGAGGGGATGCCACAGAAAGGAAGTGGCAGAGCCAAATTGTTACAGAGTCCAAACAGAAAAGAACACATTTCAACTAACCACAACAAATGTTACATTTACATGTGAGCTAAGAGACAATTTAGAGAAAGATGAAGGTAGGTGCTTTTAGGATGTGGGAGCAAAACTTCACAGGGAGGGGAGGAATGGCTGTCAGAAGAGGGTTCTTGAAGCCAGACTGACTAGAGCACCCTCAGTTCCTAGCTGAGCCCAGATTGCCCATCTCCTCTGGCCACTGCTGCAGACACCTGCCTTAACTCTCACACCTCGAAGACTCCAGCTTTGCCTTAAAGGTCCTTCCTAAATCTCCCTAGTCTTGCCTGGCATCTCCTTTAAGACAAGAAATCCTTGTACAACTGGGTGGGAGAAAGGAACTCTGGGTAACATCCTTCCTTCTGGGGTGTTCCATGGGAGCAGGAGTGAGACGGCGCTTCCCTTAtggaagagggaggagacaggGTGCTTCTCAGAAGCttctctgtaaggcaaaaacCAAACTTTAAACAGACTAACCTGCCCTAATATACTCACCCCCTCGTGCTGCTGTGAGGTTGCTCCTAGCCTGTGCTCCTCTGTCTGCAGCGTGCACAGCCTTGTTCTAACCCTGGAATAAAGGTGACTGACTCTACCGTA

Publications

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