Summary

Gene Name	MRPL21
Specie	Homo sapiens
Full Name	mitochondrial ribosomal protein L21
Also known as	L21mt|MRP-L21
Coordinate	chr11:68891278-68903832
Strand	-
Gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Retrocopy(s) from MRPL21

Retroname	Coord	Strand	Genomic Region	ENSG
MRPL21P1	chr12:68143353-68143748	+	Intergenic	ENSG00000256708	UCSC

Expression

Transcript Sequences

>NM_181514.2

GTTTCCGGCCGAGGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGTCCTGCTGGTTGGGGCAGACAACTTCACGCTGCTTGGCAAGCCACTCCTCGGAAAGGATCTTGTTCGAGTAGAAGCCACAGTCATTGAAAAGACAGAATCATGGCCAAGAATCATTATGAGATTCAGGAAAAGGAAAAACTTCAAGAAGAAAAGAATCGTCACGACCCCGCAGACTGTCCTCCGGATAAACAGCATTGAGATTGCTCCGTGTTTGTTGTGATTACCGAGTTAATACTTACAAAAGGATAAAAATAAACTCCTGCTTCCCAAGGA