Summary

Gene Name	Nlrp5
Specie	Mus musculus
Full Name	NLR family, pyrin domain containing 5
Also known as	Mater|Nalp5|Op1|PAN11
Coordinate	chr7:23085314-23141348
Strand	+
Gene summary	This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Retrocopy(s) from Nlrp5

Retroname	Coord	Strand	Genomic Region	ENSG
Nlrp5P2	chr12:3278637-3279860	-	Intergenic	ENSMUSG00000112719	UCSC
Nlrp5P1	chr7:5307957-5311133	+	Intragenic	ENSMUSG00000109155	UCSC

Expression

Transcript Sequences

>NM_001039143.2

AGAGACAGAATTGGCTTTCTTTTTGCGGTGGTTACCGGTTTGCAGAAAGTAGGATCTGCACTTAGAGAAAGCACAATGGGTCctccagaaaaagaaagtaaagcaaTCTTGAAAGCACGTGGATTGGAAGAGGAACAGAAGTCAGaaagaaaaatgacttcTCCAGAAAACGACAGTAAATCAATCCAGAAAGACCAAGGACCAGAGCAGGAGCAGACATCAGAAAGCACAATGGGTCCTCCAGAAAAAGACAGTAAAGCAATCTTGAAAGCACGTGGATTGGAAGAGGAACAGAAGTCAGAAAGCACAATGTCTCCTTCAGAAAATGTCAGTAGAGCAATCCTGAAAGACAGTGGATCAGAAGAAGTGGAACAGGCGTCAGaaagaaaaatgacttcTCCAGAAAACGACAGTAAATCAATCCAGAAAGACCAAGGACCAGAGCAGGAGCAGACATCAGATAATGGAGGTGACTTACAAGACTACAAGGCCCATGTGATTGCTAAGTTCGACACAAGTGTGGATCTACACTATGACAGCCCAGAGATGAAATTATTGTCTGATGCTTTTAAACCATACCAGAAAACCTTCCAGCCTCACACCATTATCCTACATGGAAGACCAGGAGTTGGGAAGTCAGCTTTGGCCAGAAGTATTGTTCTTGGCTGGGCACAGGGTAAACTCTTCCAAAAAATGTCCTTTGTCATCTTCTTCTCTGTTAGAGAAATAAAGTGGACAGAGAAGAGCAGTTTGGCACAGCTGATTGCTAAGGAGTGTCCAGACTCCTGGGATCTAGTGACAAAGATCATGTCCCAACCAGAAAGACTCTTGTTTGTCATAGATGGCTTGGATGATATGGACTCTGTCCTCCAACATGATGATATGACACTATCCAGAGACTGGAAGGATGAACAGCCCATATACATCCTGATGTACAGCCTCCTGAGGAAGGCTCTCCTACCTCAGTCCTTTCTCATCATTACCACCAGAAACACAGGCTTAGAAAAACTCAAGTCAATGGTTGTGTCCCCCCTCTATATACTGGTTGAAGGACTGTCTGCATCAAGGAGATCTCAGCTGGTCCTCGAGAACATCTCCAATGAGTCTGATAGAATACAAGTCTTCCATTCTCTGATAGAAAATCACCAGCTGTTTGACCAATGCCAGGCCCCCTCTGTGTGCTCCCTGGTCTGTGAGGCTCTACAGCTACagaagaaactgggaaagagatGCACCCTACCCTGCCAGACTCTCACCGGTTTGTATGCCACGTTGGTGTTTCACCAGCTCACCTTGAAAAGGCCTTCCCAGAGCGCTCTCAGTCAGGAAGAACAGATTACTCTAGTGGGTTTGTGCATGATGGCAGCTGAAGGAGTGTGGACCATGAGGTCGGTGTTCTATGATGATGACCTGAAGAACTATAGCCTAAAGGAGTCTGAGATCTTGGCCCTCTTTCACATGAACATCCTTCTCCAGGTTGGCCACAACAGTGAGCAGTGTTATGTtttctcccacctcagcctgCAGGATTTCTTTGCTGCCTTATATTATGTTTTAGAAGGGCTGGAGGAATGGAATCAGCATTTTTGCTTCATTGAAAACCAAAGGAGCATCATGGAGGTGAAGAGAACTGACGACACTCGCCTCCTCGGGATGAAGCGTTTCTTATTTGGCCTCATGAACAAGGATATCTTGAAGACTCTGGAGGTTCTGTTTGAATATCCCGTGATTCCAACTGTTGAGCAGAAGCTCCAACACTGGGTCTCTCTGATAGCTCAGCAGGTCAATGGCACCAGCCCAATGGACACCCTGGATGCCTTCTATTGTCTATTTGAGTCTCAGGATGAAGAGTTTGTTGGCGGGGCTCTCAAACGCTTCCAAGAAGTGTGGCTGCTGATTAACCAGAAGATGGACTTGAAGGTCTCTTCCTACTGTCTCAAGCACTGTCAGAACTTGAAGGCAATCCGGGTGGATATCAGAGACCTCCTCTCGGTAGATAATACTCTCGAGCTGTGCCCTGTTGTTACTGTCCAGGAGACACAATGTAAGCCCCTCCTCATGGAGTGGTGGGGAAACTTCTGCTCTGTGCTTGGCAGCCTCCGGAACTTGAAGGAGCTGGACTTGGGCGACAGCATCCTGAGTCAACGGGCCATGAAGATACTGTGCCTCGAGCTGCGGAATCAGTCCTGCAGAATACAGAAGCTGACGTTTAAGAGTGCAGAGGTAGTGTCTGGCCTGAAACATCTCTGGAAGCTCCTTTTTAGCAATCAAAACTTAAAGTACCTCAATCTAGGGAACACTCCCATGAAGGATGATGACATGAAGTTAGCCTGCGAAGCGCTGAAACATCCAAAGTGCTCCGTGGAGACTCTGAGGTTGGATTCCTGTGAGTTAACCATCATTGGTTATGAGATGATCTCCACGCTTCTTATTTCAACCACCAGGCTAAAGTGTCTCAGCCTGGCCAAAAATAGAGTGGGAGTAAAAAGCATGATATCCCTTGGGAATGCCTTGAGTAGCTCAATGTGTCTACTGCAAAAGTTGATACTGGACAACTGTGGCCTCACACCTGCCAGCTGCCACCTTCTGGTCTCAGCCCTTTTCAGCAACCAGAACTTGACACACCTGTGCCTGTCAAACAACAGCCTGGGGACTGAAGGAGTGCAACAGCTGTGTCAGTTCCTGAGGAATCCAGAATGTGCTCTCCAGCGGCTGATACTGAATCACTGCAACATTGTAGATGATGCTTATGGCTTCCTGGCAATGAGACTTGCAAACAACACAAAGCTGACCCACCTGAGCCTGACCATGAACCCCGTAGGGGATGGTGCAATGAAGCTACTGTGTGAAGCTTTAAAGGAACCTACTTGTTACCTTCAAGAACTGGAACTAGTGGACTGCCAACTCACACAGAACTGCTGCGAGGACCTGGCCTGTATGATCACAACAACCAAGCACTTAAAAAGTTTGGATCTTGGTAACAACGCCCTGGGTGACAAAGGAGTCATAACCCTGTGTGAGGGACTGAAGCAAAGTAGCAGCTCCCTGAGGAGACTTGGGTTGGGGGCATGTAAGTTGACTTCCAATTGCTGTGAGGCATTGTCATTGGCCATCTCTTGCAACCCTCACCTGAACAGCCTAAACCTGGTGAAGAATGACTTCAGTACATCGGGGATGTTGAAGCTGTGCTCTGCGTTCCAATGCCCTGTCTCTAACCTGGGGATAATTGGCCTGTGGAAGCAGGAGTACTATGCCCGAGTGAGAAGACAGCTGGAGGAAGTTGAGTTTGTCAAGCCCCACGTGGTGATTGATGGTGATTGGTATGCTAGTGATGAAGATGACCGAAACTGGTGGAAAAACTGAAGACATGAGCCCCCTCTCCTTCACGTCCTAGCACTGCAGTATCTGTGAAATGTTTGTCTCACCTTGGAGGATGTAGCAAGAATGAAATAAACACAGCATTTAGAAAAGCA

>NM_011860.3

AGAGACAGAATTGGCTTTCTTTTTGCGGTGGTTACCGGTTTGCAGAAAGTAGGATCTGCACTTAGAGAAAGCACAATGGGTCctccagaaaaagaaagtaaagcaaTCTTGAAAGCACGTGGATTGGAAGAGGAACAGAAGTCAGaaagaaaaatgacttcTCCAGAAAACGACAGTAAATCAATCCAGAAAGACCAAGGACCAGAGCAGGAGCAGACATCAGAAAGCACAATGGGTCCTCCAGAAAAAGACAGTAAAGCAATCTTGAAAGCACGTGGATTGGAAGAGGAACAGAAGTCAGAAAGCACAATGTCTCCTTCAGAAAATGTCAGTAGAGCAATCCTGAAAGACAGTGGATCAGAAGAAGTGGAACAGGCGTCAGaaagaaaaatgacttcTCCAGAAAACGACAGTAAATCAATCCAGAAAGACCAAGGACCAGAGCAGGAGCAGACATCAGaAACCTTACAATCTAAGGAAGAAGATGAAGTGACAGAGGCAGATAAAGATAATGGAGGTGACTTACAAGACTACAAGGCCCATGTGATTGCTAAGTTCGACACAAGTGTGGATCTACACTATGACAGCCCAGAGATGAAATTATTGTCTGATGCTTTTAAACCATACCAGAAAACCTTCCAGCCTCACACCATTATCCTACATGGAAGACCAGGAGTTGGGAAGTCAGCTTTGGCCAGAAGTATTGTTCTTGGCTGGGCACAGGGTAAACTCTTCCAAAAAATGTCCTTTGTCATCTTCTTCTCTGTTAGAGAAATAAAGTGGACAGAGAAGAGCAGTTTGGCACAGCTGATTGCTAAGGAGTGTCCAGACTCCTGGGATCTAGTGACAAAGATCATGTCCCAACCAGAAAGACTCTTGTTTGTCATAGATGGCTTGGATGATATGGACTCTGTCCTCCAACATGATGATATGACACTATCCAGAGACTGGAAGGATGAACAGCCCATATACATCCTGATGTACAGCCTCCTGAGGAAGGCTCTCCTACCTCAGTCCTTTCTCATCATTACCACCAGAAACACAGGCTTAGAAAAACTCAAGTCAATGGTTGTGTCCCCCCTCTATATACTGGTTGAAGGACTGTCTGCATCAAGGAGATCTCAGCTGGTCCTCGAGAACATCTCCAATGAGTCTGATAGAATACAAGTCTTCCATTCTCTGATAGAAAATCACCAGCTGTTTGACCAATGCCAGGCCCCCTCTGTGTGCTCCCTGGTCTGTGAGGCTCTACAGCTACagaagaaactgggaaagagatGCACCCTACCCTGCCAGACTCTCACCGGTTTGTATGCCACGTTGGTGTTTCACCAGCTCACCTTGAAAAGGCCTTCCCAGAGCGCTCTCAGTCAGGAAGAACAGATTACTCTAGTGGGTTTGTGCATGATGGCAGCTGAAGGAGTGTGGACCATGAGGTCGGTGTTCTATGATGATGACCTGAAGAACTATAGCCTAAAGGAGTCTGAGATCTTGGCCCTCTTTCACATGAACATCCTTCTCCAGGTTGGCCACAACAGTGAGCAGTGTTATGTtttctcccacctcagcctgCAGGATTTCTTTGCTGCCTTATATTATGTTTTAGAAGGGCTGGAGGAATGGAATCAGCATTTTTGCTTCATTGAAAACCAAAGGAGCATCATGGAGGTGAAGAGAACTGACGACACTCGCCTCCTCGGGATGAAGCGTTTCTTATTTGGCCTCATGAACAAGGATATCTTGAAGACTCTGGAGGTTCTGTTTGAATATCCCGTGATTCCAACTGTTGAGCAGAAGCTCCAACACTGGGTCTCTCTGATAGCTCAGCAGGTCAATGGCACCAGCCCAATGGACACCCTGGATGCCTTCTATTGTCTATTTGAGTCTCAGGATGAAGAGTTTGTTGGCGGGGCTCTCAAACGCTTCCAAGAAGTGTGGCTGCTGATTAACCAGAAGATGGACTTGAAGGTCTCTTCCTACTGTCTCAAGCACTGTCAGAACTTGAAGGCAATCCGGGTGGATATCAGAGACCTCCTCTCGGTAGATAATACTCTCGAGCTGTGCCCTGTTGTTACTGTCCAGGAGACACAATGTAAGCCCCTCCTCATGGAGTGGTGGGGAAACTTCTGCTCTGTGCTTGGCAGCCTCCGGAACTTGAAGGAGCTGGACTTGGGCGACAGCATCCTGAGTCAACGGGCCATGAAGATACTGTGCCTCGAGCTGCGGAATCAGTCCTGCAGAATACAGAAGCTGACGTTTAAGAGTGCAGAGGTAGTGTCTGGCCTGAAACATCTCTGGAAGCTCCTTTTTAGCAATCAAAACTTAAAGTACCTCAATCTAGGGAACACTCCCATGAAGGATGATGACATGAAGTTAGCCTGCGAAGCGCTGAAACATCCAAAGTGCTCCGTGGAGACTCTGAGGTTGGATTCCTGTGAGTTAACCATCATTGGTTATGAGATGATCTCCACGCTTCTTATTTCAACCACCAGGCTAAAGTGTCTCAGCCTGGCCAAAAATAGAGTGGGAGTAAAAAGCATGATATCCCTTGGGAATGCCTTGAGTAGCTCAATGTGTCTACTGCAAAAGTTGATACTGGACAACTGTGGCCTCACACCTGCCAGCTGCCACCTTCTGGTCTCAGCCCTTTTCAGCAACCAGAACTTGACACACCTGTGCCTGTCAAACAACAGCCTGGGGACTGAAGGAGTGCAACAGCTGTGTCAGTTCCTGAGGAATCCAGAATGTGCTCTCCAGCGGCTGATACTGAATCACTGCAACATTGTAGATGATGCTTATGGCTTCCTGGCAATGAGACTTGCAAACAACACAAAGCTGACCCACCTGAGCCTGACCATGAACCCCGTAGGGGATGGTGCAATGAAGCTACTGTGTGAAGCTTTAAAGGAACCTACTTGTTACCTTCAAGAACTGGAACTAGTGGACTGCCAACTCACACAGAACTGCTGCGAGGACCTGGCCTGTATGATCACAACAACCAAGCACTTAAAAAGTTTGGATCTTGGTAACAACGCCCTGGGTGACAAAGGAGTCATAACCCTGTGTGAGGGACTGAAGCAAAGTAGCAGCTCCCTGAGGAGACTTGGGTTGGGGGCATGTAAGTTGACTTCCAATTGCTGTGAGGCATTGTCATTGGCCATCTCTTGCAACCCTCACCTGAACAGCCTAAACCTGGTGAAGAATGACTTCAGTACATCGGGGATGTTGAAGCTGTGCTCTGCGTTCCAATGCCCTGTCTCTAACCTGGGGATAATTGGCCTGTGGAAGCAGGAGTACTATGCCCGAGTGAGAAGACAGCTGGAGGAAGTTGAGTTTGTCAAGCCCCACGTGGTGATTGATGGTGATTGGTATGCTAGTGATGAAGATGACCGAAACTGGTGGAAAAACTGAAGACATGAGCCCCCTCTCCTTCACGTCCTAGCACTGCAGTATCTGTGAAATGTTTGTCTCACCTTGGAGGATGTAGCAAGAATGAAATAAACACAGCATTTAGAAAAGCA