Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Nlrp5P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr7:5307957-5311133  UCSC
Strand +
Parental Sequence NM_011860.3
Parental seq. overlap 2627 bp
Parental seq. overlap (%) 74.5%
Genomic Region Intragenic (Nlrp2)
Retrocopy Summary Nlrp5P1, located on chr7:5307957-5311133, is a retrocopy of the parental gene Nlrp5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Nlrp5
Full Name NLR family, pyrin domain containing 5
Also known as Mater|Nalp5|Op1|PAN11
Coordinate chr7:23085314-23141348
Strand +
Gene summary This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Nlrp5P1
ATCAGAAAGCACAATGAGTCCTCCAGAAAAAGACAGTAAAGCGATCCTGAAAGACCAAGGACCAGACTGGGAAGAGACATCAGAAGCCTTATAAGCTGAGAAAGAAGATGCACTGACAAAAGCATATGAACAAGGTAACCTACAGACAACAAGGCCCATGTGATAGCTAAATTCAACACCAGTTTGGATCTACACTATGACAGCCCAGAGATGAAAGTATCACCTGATGCTTTTAAACCATACCAGAAAACTTTCAGGCCTCACACCATTATCCTACACGGAAGACCATGAGTTTGGAAGTCAGCTTGGCCAGAAGTATTGCTCTGAGCTGGGCACAGGGTGAACTCTACCAAGACATGTCCAATGTTGTCGattagAGAAAGAAAGTGGACAGAAAAGAGCAGTTTGGCATAGCTGATTGCCAAGGAGTGGCTAGACTCCTAGGCTGCAGTGACAAAGATCATGTTCCAACCAGAAAGACTCCTGTTTGTTATAGATGGTTTGGATGATATGGGCTCTGTCCTCCAACCTGATGATATGACACTCTCCAGAGACTGGAAGGATGAACAGCCCATATACATCCTGATGTACAGCCTCCTGAGGAAGTTCCTCCTACCCCAGTCCTTTCTCATCATTACCACCAGAACCACAGGCTGAGAAAAGTCCAAGTCAACGTGGTGCCCCCCTCTCTATATACTGGTTGAAGGATTATCTGCATAAAAGAGATCTCACCTGGTCTTCGAGAACATCTTTGATGGCTATCAGAGAATGCAAGTCTTCCATTCTATGATAGAAAATCACCAGCTATTTGACCAGTGCCAGGATCCCTCTGTATGCTCAATGGTTTGTGAGGCTCTATAGCTACAGAAGCTGGGAAAGAGATTCACCATACCCTGCCAGACTCTCACCAGTTTGTATGCTACATTGGTGTTCCACCAGTTCACCTTGAGAAAGCCTTCCAAGAGCGCTCTCAGTCAGGAAGAGCAAATTACCCTAATGAGTTTGTGCAGGGTGTCAGCTGAGATCTCAGCCCTCTTTCATATGAACATCCTTCTCCAGGTTGGCCACAGCAGTGAGCAGTGTTATATTTTCTTCTATCTCAGCCTTCAGAATTTCTTTGCTGACTTATGTTTTAGAATGGTTGGGGGAATGAAATcagtatttttttccttcattaaaaaccaaaaaagcatCATGGAGGTAAAGAGAGTCAACACTCACCTCCTCAGCATGAATCATTTCTTATTTGGCCTCATGCACAAGGATATCTTGAAGATTCTGGAGGTTCTGTTTGAATGTCCTGTGACTCTGACTGTCAAGCAGAAGCTCCAACACTGGGTCTCTCTGATAGGTCAGTAGGTCAAGGGCACCAGCCTGATAGACATCCTGGATGCCTTCTACTATCTGAGTCTCAAGATATAGAGTTTGTTCACATGGCTTTCAACCACTTCTAAGAAGTGTGGCTTCTGATTAACCAGGAGATGGACTTGATGGTACCTTCCTATTGTCTCCAGCACTGTCAGAACCTGAAGACAATCAGGGTGGATATCAGAGATGTCTTCTCAGTGGATAATACTCTTGAGCTGTGTCCTGTTGTTGCTCTTCAGGAGACACAATGTAAGCCCCTCCTCATGGAGTGGTGGGGAGCCTTCTGCTCTGTGTTCAGCACCCACCCAAACTTGAAGGAGCTGGACTTGAGTGACAGCATCCTGAACAAATGGGCTGTGAAGATACTGTGCCTCAAGCTGAGGAATCTGTCCTGCAGTACACAGAAGCTGATATTTAAGAGTGCAGATGTAGTGTCTGGCCTGAAATATCTTTGGATGCTCCTTGTTAGCAATCAGAACTTAAACTTTTTTGATCTAGGGAACACTCCCATGAAGGATGATGACATCAAGTTAGCCTGTGATGTGCTGAAACATCCAAGCTGCTCCCTGGAGACTCTGGGGTTGGATTCCTGGGAGTTAACCCTCACTGGTTAGGAGATGATCTCCATGCTAATACTTTCAACCACCAGTCTAAAGTGCCTCAGCCTGGCCAAAAATAAGGTGGCAGTAAAGAGCATGATATCATTTGGGAATGTCTTGAGTAGTTCAATGTGTCCACTGCAGAAGCTGATACCGGACAGCTGTGACCTCACACCTGCAGCTGCAACCTTCTGGCATCAGCCCTTTTCAGCAACCAGAACTCGACTCACCTGAGCCTGTCAAACAACATCAGTTCATGAGGAATCCAGAATGTACTCTCCAGTGGCTGATACTGAATTGCTGCAATATTATAGATAATGCCTAAGACTTCCTGGCATTGATACttacaaacaacagaaagctgacaCACCTGTGCCTGACCATGACCTCTGTACAGAATAGTGCAATGAAGCTACTGTGTGAAGCTTTAAAGGAGCCCACTTGTTACCTTCAAGAACTGGAACTAGTGGACTGCCCGCTCATGGAGAACTGCTGCCAGGACCTGTTGTATGATCACAACAACCAAGCACTTCAAAGGCTTGGTAACACTGCCCTGGGTGACAAAGGAGTTATAACTCTGTTAGAGGGACTGAAGCAAAGTAGCGGCTCCCAGGGGAGACTTGGGTTGGGAGCATGTGAGTTCACTTCCAACCACTGTGAGGCAATGTCATCGGCCCTGTCTTGAAACCCGAACCTGAACAGCCTAAACCTGGTGAAGAATAACTTCAGCACATCAGGGATGTTGAAGCTGTGCTCTGCGTTCCAATTCCTTGCCTCTAACCTGTGGATAATTGGTCTGTGGAAACAGCAGTGCTATGCCTAGGTGAGAAGACAGCTGGAAAGTGTAGTTTATCAAGCCCCACATGGTGATTGATGGTGACCGGTATGCTATTGATAGAAGATGACTGTAACTGGTGGAAAAACTGAAGACATGAGTCCCCTTCTCTCGTTCACATCCTAGGACTTCTTTATCTGTGAAATGTTTGTCTCACCTCAGAGAATGTAGTGAGAATGAAAGAAACAGAGCATttagaaaagca
>NM_011860.3
AGAGACAGAATTGGCTTTCTTTTTGCGGTGGTTACCGGTTTGCAGAAAGTAGGATCTGCACTTAGAGAAAGCACAATGGGTCctccagaaaaagaaagtaaagcaaTCTTGAAAGCACGTGGATTGGAAGAGGAACAGAAGTCAGaaagaaaaatgacttcTCCAGAAAACGACAGTAAATCAATCCAGAAAGACCAAGGACCAGAGCAGGAGCAGACATCAGAAAGCACAATGGGTCCTCCAGAAAAAGACAGTAAAGCAATCTTGAAAGCACGTGGATTGGAAGAGGAACAGAAGTCAGAAAGCACAATGTCTCCTTCAGAAAATGTCAGTAGAGCAATCCTGAAAGACAGTGGATCAGAAGAAGTGGAACAGGCGTCAGaaagaaaaatgacttcTCCAGAAAACGACAGTAAATCAATCCAGAAAGACCAAGGACCAGAGCAGGAGCAGACATCAGaAACCTTACAATCTAAGGAAGAAGATGAAGTGACAGAGGCAGATAAAGATAATGGAGGTGACTTACAAGACTACAAGGCCCATGTGATTGCTAAGTTCGACACAAGTGTGGATCTACACTATGACAGCCCAGAGATGAAATTATTGTCTGATGCTTTTAAACCATACCAGAAAACCTTCCAGCCTCACACCATTATCCTACATGGAAGACCAGGAGTTGGGAAGTCAGCTTTGGCCAGAAGTATTGTTCTTGGCTGGGCACAGGGTAAACTCTTCCAAAAAATGTCCTTTGTCATCTTCTTCTCTGTTAGAGAAATAAAGTGGACAGAGAAGAGCAGTTTGGCACAGCTGATTGCTAAGGAGTGTCCAGACTCCTGGGATCTAGTGACAAAGATCATGTCCCAACCAGAAAGACTCTTGTTTGTCATAGATGGCTTGGATGATATGGACTCTGTCCTCCAACATGATGATATGACACTATCCAGAGACTGGAAGGATGAACAGCCCATATACATCCTGATGTACAGCCTCCTGAGGAAGGCTCTCCTACCTCAGTCCTTTCTCATCATTACCACCAGAAACACAGGCTTAGAAAAACTCAAGTCAATGGTTGTGTCCCCCCTCTATATACTGGTTGAAGGACTGTCTGCATCAAGGAGATCTCAGCTGGTCCTCGAGAACATCTCCAATGAGTCTGATAGAATACAAGTCTTCCATTCTCTGATAGAAAATCACCAGCTGTTTGACCAATGCCAGGCCCCCTCTGTGTGCTCCCTGGTCTGTGAGGCTCTACAGCTACagaagaaactgggaaagagatGCACCCTACCCTGCCAGACTCTCACCGGTTTGTATGCCACGTTGGTGTTTCACCAGCTCACCTTGAAAAGGCCTTCCCAGAGCGCTCTCAGTCAGGAAGAACAGATTACTCTAGTGGGTTTGTGCATGATGGCAGCTGAAGGAGTGTGGACCATGAGGTCGGTGTTCTATGATGATGACCTGAAGAACTATAGCCTAAAGGAGTCTGAGATCTTGGCCCTCTTTCACATGAACATCCTTCTCCAGGTTGGCCACAACAGTGAGCAGTGTTATGTtttctcccacctcagcctgCAGGATTTCTTTGCTGCCTTATATTATGTTTTAGAAGGGCTGGAGGAATGGAATCAGCATTTTTGCTTCATTGAAAACCAAAGGAGCATCATGGAGGTGAAGAGAACTGACGACACTCGCCTCCTCGGGATGAAGCGTTTCTTATTTGGCCTCATGAACAAGGATATCTTGAAGACTCTGGAGGTTCTGTTTGAATATCCCGTGATTCCAACTGTTGAGCAGAAGCTCCAACACTGGGTCTCTCTGATAGCTCAGCAGGTCAATGGCACCAGCCCAATGGACACCCTGGATGCCTTCTATTGTCTATTTGAGTCTCAGGATGAAGAGTTTGTTGGCGGGGCTCTCAAACGCTTCCAAGAAGTGTGGCTGCTGATTAACCAGAAGATGGACTTGAAGGTCTCTTCCTACTGTCTCAAGCACTGTCAGAACTTGAAGGCAATCCGGGTGGATATCAGAGACCTCCTCTCGGTAGATAATACTCTCGAGCTGTGCCCTGTTGTTACTGTCCAGGAGACACAATGTAAGCCCCTCCTCATGGAGTGGTGGGGAAACTTCTGCTCTGTGCTTGGCAGCCTCCGGAACTTGAAGGAGCTGGACTTGGGCGACAGCATCCTGAGTCAACGGGCCATGAAGATACTGTGCCTCGAGCTGCGGAATCAGTCCTGCAGAATACAGAAGCTGACGTTTAAGAGTGCAGAGGTAGTGTCTGGCCTGAAACATCTCTGGAAGCTCCTTTTTAGCAATCAAAACTTAAAGTACCTCAATCTAGGGAACACTCCCATGAAGGATGATGACATGAAGTTAGCCTGCGAAGCGCTGAAACATCCAAAGTGCTCCGTGGAGACTCTGAGGTTGGATTCCTGTGAGTTAACCATCATTGGTTATGAGATGATCTCCACGCTTCTTATTTCAACCACCAGGCTAAAGTGTCTCAGCCTGGCCAAAAATAGAGTGGGAGTAAAAAGCATGATATCCCTTGGGAATGCCTTGAGTAGCTCAATGTGTCTACTGCAAAAGTTGATACTGGACAACTGTGGCCTCACACCTGCCAGCTGCCACCTTCTGGTCTCAGCCCTTTTCAGCAACCAGAACTTGACACACCTGTGCCTGTCAAACAACAGCCTGGGGACTGAAGGAGTGCAACAGCTGTGTCAGTTCCTGAGGAATCCAGAATGTGCTCTCCAGCGGCTGATACTGAATCACTGCAACATTGTAGATGATGCTTATGGCTTCCTGGCAATGAGACTTGCAAACAACACAAAGCTGACCCACCTGAGCCTGACCATGAACCCCGTAGGGGATGGTGCAATGAAGCTACTGTGTGAAGCTTTAAAGGAACCTACTTGTTACCTTCAAGAACTGGAACTAGTGGACTGCCAACTCACACAGAACTGCTGCGAGGACCTGGCCTGTATGATCACAACAACCAAGCACTTAAAAAGTTTGGATCTTGGTAACAACGCCCTGGGTGACAAAGGAGTCATAACCCTGTGTGAGGGACTGAAGCAAAGTAGCAGCTCCCTGAGGAGACTTGGGTTGGGGGCATGTAAGTTGACTTCCAATTGCTGTGAGGCATTGTCATTGGCCATCTCTTGCAACCCTCACCTGAACAGCCTAAACCTGGTGAAGAATGACTTCAGTACATCGGGGATGTTGAAGCTGTGCTCTGCGTTCCAATGCCCTGTCTCTAACCTGGGGATAATTGGCCTGTGGAAGCAGGAGTACTATGCCCGAGTGAGAAGACAGCTGGAGGAAGTTGAGTTTGTCAAGCCCCACGTGGTGATTGATGGTGATTGGTATGCTAGTGATGAAGATGACCGAAACTGGTGGAAAAACTGAAGACATGAGCCCCCTCTCCTTCACGTCCTAGCACTGCAGTATCTGTGAAATGTTTGTCTCACCTTGGAGGATGTAGCAAGAATGAAATAAACACAGCATTTAGAAAAGCA

Publications

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