Summary

Gene Name	Akr1b1
Specie	Rattus norvegicus
Full Name	aldo-keto reductase family 1 member B1
Also known as	ALDRED|ALR-P-I|Akr1b3|Akr1b4|Aldr1|Alr|RATALDRED
Coordinate	chr4:61706866-61720959
Strand	-
Gene summary	Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]

Retrocopy(s) from Akr1b1

Retroname	Coord	Strand	Genomic Region	ENSG
Akr1b1P1	chr3:173936926-173938250	+	Intragenic	N/A	UCSC
Akr1b1P2	chr3:76784304-76784901	+	Intergenic	N/A	UCSC
Akr1b1P3	chr4:148951016-148952599	-	Intergenic	N/A	UCSC
Akr1b1P4	chr5:38981170-38982335	+	Intragenic	N/A	UCSC
Akr1b1P5	chr6:47724151-47725156	+	Intergenic	N/A	UCSC
Akr1b1P6	chr19:10629970-10631259	-	Intergenic	N/A	UCSC
Akr1b1P7	chr19:2584321-2585481	-	Intergenic	N/A	UCSC

Expression

Transcript Sequences

>NM_012498.1

GCACTCTTGCGGGTCGTTGTGCGTAACTTGCAGCAATCATGGCTAGCCATCTGGAACTCAACAACGGCACCAAGATGCCCACCCTGGGTCTGGGCACCTGGAAGTCTCCTCCTGGCCAGGTGACCGAGGCTGTGAAGGTTGCTATCGACATGGGGTATCGCCACATTGACTGCGCCCAGGTGTACCAGAATGAGAAGGAGGTGGGGGTGGCCCTCCAGGAGAAGCTCAAGGAGCAGGTGGTGAAGCGCCAGGATCTCTTCATTGTCAGCAAGCTGTGGTGCACGTTCCACGACCAGAGCATGGTGAAAGGGGCCTGCCAGAAGACGCTGAGCGACCTGCAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCAACTGGCTTCAAGCCTGGGCCTGACTATTTCCCCCTGGATGCATCGGGAAACGTGATTCCTAGTGACACCGATTTTGTGGACACTTGGACGGCTATGGAGCAACTAGTGGATGAAGGTTTGGTAAAAGCAATCGGAGTCTCCAACTTCAACCCTCTTCAGATTGAGAGGATCTTGAACAAACCTGGCTTAAAGTATAAGCCTGCTGTTAACCAGATCGAGTGCCACCCATACCTAACTCAGGAGAAGCTGATTGAGTACTGCCATTGCAAAGGCATCGTGGTGACTGCATACAGTCCCCTTGGTTCTCCTGACAGGCCCTGGGCCAAGCCTGAGGACCCCTCTCTCCTGGAGGATCCCAGGATCAAGGAAATTGCAGCCAAGTACAATAAAACTACAGCCCAGGTGCTGATCCGGTTCCCCATCCAAAGGAACCTGGTCGTGATCCCCAAGTCTGTGACACCAGCACGTATTGCTGAGAACTTTAAGGTCTTTGACTTTGAGCTGAGCAATGAGGACATGGCCACTCTACTCAGCTACAACAGGAACTGGAGGGTGTGCGCCTTGATGAGCTGTGCCAAACACAAGGATTACCCCTTCCACGCAGAAGTCTGAAGCTGTGGTGGACGAATCCTGCTCCTCCCCAAGCGACTTAACACATGTTCTTTCTGCCTCATCTGCCCTTGCAAGTGTCCCTCTGCACTGGGTGGCACCTTGCAGACCAGATGGTGAGAGTTTGTTAGTTTGACGTAGAATGTGGAGGGCAGTACCAGTAGCTGAGGAGTTTCTTCGGCCTTTCTTGGTCTTCTTCCCACCTGGAGGACTTTAACACGAGTACCTTTTCCAACCAAAGAGAAAGCAAGATTTATAGCCCAAGTCATGCCACTAACACTTAAATTTGAGTGCTTAGAACTCCAGTCCTATGGGGGTCAGACTTTTTGCCTCAAATAAAAACTGCTTTTGTG