Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Akr1b1P5
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr6:47724151-47725156  UCSC
Strand +
Parental Sequence NM_012498.1
Parental seq. overlap 912 bp
Parental seq. overlap (%) 67.8%
Genomic Region Intergenic
Retrocopy Summary Akr1b1P5, located on chr6:47724151-47725156, is a retrocopy of the parental gene Akr1b1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Akr1b1
Full Name aldo-keto reductase family 1 member B1
Also known as ALDRED|ALR-P-I|Akr1b3|Akr1b4|Aldr1|Alr|RATALDRED
Coordinate chr4:61706866-61720959
Strand -
Gene summary Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Akr1b1P5
ACTGGAATTCAACAATGGCACCAAGATGCCCACCCTGGACATGGGCACCTGGAAATCTCCTCCTATCCAGGTGACTGAGGCTGTGAAGGTTGCTATTGACATGGGGTACTGCCCCATTGACTGTGCCCAAGTGTACCAGAATGAGAAGGAGGTGGGGGTGGCCCTCTAGGAGAAGCTTAAGGAGCAGATGGTGAAGCACCAGGATCTCTTCATCGCCAACAAGCTGTGGTACACGTTCCACAACAAGAGCAAGGTAAAAGAAACCTGCCAGAAGACACTGAGCAACCTGCTGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCAACAGGCTTCAAGCCTGGTCCTGACTATTTCCAACTGGATGCATCAGGAAGCATGATTCCTAGTGACACAGATTTTGTGGACACTGGGACAGTTATAGAACAACTAGTAGATGGAGGTTTGGTAAAAGCAATTGGTGTCTCCAACTTCAACCTTCTTCAGATGGAGAGGATCTTGAACAAACCTGGCTTAAAATATAAGCCTGCCATTAACCAGACCGAGTGCCACCCATACCTAACTCAGGAGAAGCTGATTGAGTACTACCATTACAAAGGCATCATGGTGACAGCATACAGTCCTCTTGGTTCTCCTGACAGGCCCTGGGCCAAGCCTGAAGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCAGCTGCAGTCGAGTACAATAAAACCACAGCCCAGGTGCTGATCCGGTTCCCTATTCAAAGGAACTTGGTAGTGATCCCCAAGTCTGTGACATCAGCATGCATTGCTGAGAACTTCAAGGTCTTTGAAGTTGAGCAGCAAGTGAGGACATGACCAGAACTGGAGGGTGTGTGCCTTGATGAGCTGTGCCAAACACAAGGATTACCCCTTCCACGCAGAAGTCTGAAGCTGTGCTGTGGTAGACAGATACCTGCTCCTCCTCAAGTGACTTAACACATGTTCTTTCTGCCTCATCTGCCCTTGCAAGTGTCC
>NM_012498.1
GCACTCTTGCGGGTCGTTGTGCGTAACTTGCAGCAATCATGGCTAGCCATCTGGAACTCAACAACGGCACCAAGATGCCCACCCTGGGTCTGGGCACCTGGAAGTCTCCTCCTGGCCAGGTGACCGAGGCTGTGAAGGTTGCTATCGACATGGGGTATCGCCACATTGACTGCGCCCAGGTGTACCAGAATGAGAAGGAGGTGGGGGTGGCCCTCCAGGAGAAGCTCAAGGAGCAGGTGGTGAAGCGCCAGGATCTCTTCATTGTCAGCAAGCTGTGGTGCACGTTCCACGACCAGAGCATGGTGAAAGGGGCCTGCCAGAAGACGCTGAGCGACCTGCAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCAACTGGCTTCAAGCCTGGGCCTGACTATTTCCCCCTGGATGCATCGGGAAACGTGATTCCTAGTGACACCGATTTTGTGGACACTTGGACGGCTATGGAGCAACTAGTGGATGAAGGTTTGGTAAAAGCAATCGGAGTCTCCAACTTCAACCCTCTTCAGATTGAGAGGATCTTGAACAAACCTGGCTTAAAGTATAAGCCTGCTGTTAACCAGATCGAGTGCCACCCATACCTAACTCAGGAGAAGCTGATTGAGTACTGCCATTGCAAAGGCATCGTGGTGACTGCATACAGTCCCCTTGGTTCTCCTGACAGGCCCTGGGCCAAGCCTGAGGACCCCTCTCTCCTGGAGGATCCCAGGATCAAGGAAATTGCAGCCAAGTACAATAAAACTACAGCCCAGGTGCTGATCCGGTTCCCCATCCAAAGGAACCTGGTCGTGATCCCCAAGTCTGTGACACCAGCACGTATTGCTGAGAACTTTAAGGTCTTTGACTTTGAGCTGAGCAATGAGGACATGGCCACTCTACTCAGCTACAACAGGAACTGGAGGGTGTGCGCCTTGATGAGCTGTGCCAAACACAAGGATTACCCCTTCCACGCAGAAGTCTGAAGCTGTGGTGGACGAATCCTGCTCCTCCCCAAGCGACTTAACACATGTTCTTTCTGCCTCATCTGCCCTTGCAAGTGTCCCTCTGCACTGGGTGGCACCTTGCAGACCAGATGGTGAGAGTTTGTTAGTTTGACGTAGAATGTGGAGGGCAGTACCAGTAGCTGAGGAGTTTCTTCGGCCTTTCTTGGTCTTCTTCCCACCTGGAGGACTTTAACACGAGTACCTTTTCCAACCAAAGAGAAAGCAAGATTTATAGCCCAAGTCATGCCACTAACACTTAAATTTGAGTGCTTAGAACTCCAGTCCTATGGGGGTCAGACTTTTTGCCTCAAATAAAAACTGCTTTTGTG

Publications

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