Summary

Gene Name	NEIL2
Specie	Homo sapiens
Full Name	nei like DNA glycosylase 2
Also known as	NEH2|NEI2
Coordinate	chr8:11769710-11787345
Strand	+
Gene summary	This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

Retrocopy(s) from NEIL2

Retroname	Coord	Strand	Genomic Region	ENSG
NEIL2P1	chr4:150421571-150423711	-	Intragenic	ENSG00000248521	UCSC

Expression

Transcript Sequences

>NM_001135746.3_2

AAATCTCCGCCCCCAGCTGGAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGGATGCCAGAAGGGCCGTTGGTGAGGAAATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGTCTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGttttttttttttttttggttgtttgttttgagagagagtcttgctctgtctccctggctagggtgtggtggtgtgatcttggctcacggcagccttgccctccctggctcaagcagtcttcatctcagcctccagagtagctgggactacaggcatgtgatatgatgctcggctgatttttgtttactttttagagagatggggtcttgccatatttgccaggctggtttgaactcctacaactcaagcattcctcccaccttggtctcccaaaatgttgggaccacgggtgtgagccaccgcgcccagcTAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACATGAAAATAAAGCTCACTGTTACTCGC