Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NEIL2P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:150421571-150423711  UCSC
Coordinates (T2T) chr4:153745391-153747531  UCSC
Coordinates (hg19) chr4:151342723-151344863  UCSC
Strand -
Parental Sequence NM_001135746.3_2
Parental seq. overlap 1139 bp
Parental seq. overlap (%) 42%
Genomic Region Intragenic (LRBA)
Retrocopy Summary NEIL2P1, located on chr4:150421571-150423711, is a retrocopy of the parental gene NEIL2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NEIL2
Full Name nei like DNA glycosylase 2
Also known as NEH2|NEI2
Coordinate chr8:11769710-11787345
Strand +
Gene summary This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NEIL2P1
Bonobo Pan paniscus NEIL2P1
Gorilla Gorilla gorilla NEIL2P1
Orangutan Pongo abelii NEIL2P1
Gibbon Nomascus leucogenys NEIL2P1
Green monkey Chlorocebus sabaeus NEIL2P1
Crab-eating macaque Macaca fascicularis NEIL2P1
Rhesus Macaca mulatta NEIL2P1
Baboon Papio anubis NEIL2P1
Marmoset Callithrix jacchus NEIL2P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NEIL2P1
AGCTCCTGTGTTTTGTTTTTGTTCTGGAACTTTGGTTGATTTTAAGGCCCTCCATTTTGAAAGCAGGAAAAGTCATTTTTTTTCCCCCTTATTTCCCTGGAGGATCCAGGGATGAGAATAGAGTGGCCTGAAAGCAGTGCTTGGATTCAGCCTCCTGCCAGGTCCTTCCTGCTGGACACAGACACCAAGACGCTGGGGTGGAGCAGAGAGCTGCACCTTCCTGGGGTGCTCAGTGGTCTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTTGTGACTATTGCTGTTGATATGTTGAACAATTCAGGAATCAAGGGCTATGGAGAAACTCCTTCAAGTTGTTGGCAACAGGTAGATGAAGCTAGGACAGTGACGTGAAACTGAAGCTCTCTGTTAAAATTCTTCCTATTGAATTGCACCATTGTGAAAGATGAGAAAAGTCACAATGATGGGTAAGGGGAAAACCTTCTGGAAGTCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAACAGTTGTGCTCCCAACATGGCTTTGCAGATGATGGGGGGTTTTTTGGGGCTGGAGCTGCTGTGCGGGGCGTGCAGTGGTGCTGGGTCGGGCCAAGGGGCTGCCCACCCGGAGCTGGGATGCCAGAAGGGCTGTTGGTGAGGACATTTCACCATTCGGTCTCTCCTTTTGTGGGCAAGCAGGTGGTAAAGACAGGGAGCAACAGTAAGAAGTATAGCCCACCAGCCTCCAGTCTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCCAGATGAAGAAATGGGGCCCGCTGGCAACAGCTCACCGCCAGAGCCTCCACAAAAAGAAGCGCAGAAGGAAGGGACTGTGGACTCAAAGCAGGCCCGGGAGCAAGTGGGCAGAAGACCCTTGACGCCTCCTCACAGTCCGCAGAGCTCGTCCCCCAGGGAGAGGATGATTAGGAATGTTTGAAGGGAGACACCCCTACAGGAGATGCTGGGAGGCGGCTGCGTGTCAGCTCTTGTTTGCTTGGCAGCGTTTGGGTGAACGACTTCTCCAGAGCCAAGAAAGCCAACAAGAAGGGGGACCGGAGGGACCCTGCCCCGAGGTTGGTCCTGTACTTTGGTGGTGGTAGCTTCCTGGCACTTTATAATTGTCAGATGCCTTGGAGCTCTTCCCCAGAGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCATTGAGGACAAGCCTTGGAAGCTCTAGGCCAGGCTCAGCCTGTCACTTATACACCATTGGACCAGAAATACTTCTCAGGGCTAGGGAACGTCATTAAGAATGAAGTCTTGTACAGAGCTGGCATCCATCCCCTTTCTCTTGGTTCAGTCCTGAGTGCCTCCATGTTAGGAGGCCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAGGGCAAACCGCAGCACATGCAGGTCTACCAGAAAGAACAGTGCCCAGCTGGCCACCAGGTCATGAAGAAGCCCTTTGGGCCCTCAGGTGGGTTCCAGAGGCTCACCTGGTGGTGCCCACAGTGCCAGTCTCAGTTGTTAGAGGAGCCGGAGCAGTGCCAGTTCTTCTAAGGAACTCAGGGTGCTCTTCATGGAACCTTGTCCCTTGGGGAACCTGATGTCTAAGTGTCCAGAGAGGAGGATGTGGTCAGGGACGGGGTGCAGAGGATAGTGTGGGTCAGGAGTGCCAGTATTATAATGTTCATCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATt
>NM_001135746.3_2
AAATCTCCGCCCCCAGCTGGAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGGATGCCAGAAGGGCCGTTGGTGAGGAAATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGTCTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCCAGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCCCTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGATCACGTGGTGGAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTCTACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAAGATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTGTCAGAGGAGCCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCACGGAACCTTGCCGCTTGGGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGATAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCGTCTCCCTGGAGTTATGTTGAAGGCAGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTTGAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCCGGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCTCCCAACATAGCTTTGCAGATGATGTGGGttttttttttttttttggttgtttgttttgagagagagtcttgctctgtctccctggctagggtgtggtggtgtgatcttggctcacggcagccttgccctccctggctcaagcagtcttcatctcagcctccagagtagctgggactacaggcatgtgatatgatgctcggctgatttttgtttactttttagagagatggggtcttgccatatttgccaggctggtttgaactcctacaactcaagcattcctcccaccttggtctcccaaaatgttgggaccacgggtgtgagccaccgcgcccagcTAGCTCCTGTGTTTTGTTTTTGTTTTGTAACTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTTTATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGATTCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGTCGTGGAGCAGGGAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTTAAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAGAAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACATGAAAATAAAGCTCACTGTTACTCGC

Publications

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