Summary

Gene Name	UHRF1
Specie	Homo sapiens
Full Name	ubiquitin like with PHD and ring finger domains 1
Also known as	ICBP90|Np95|RNF106|TDRD22|hNP95|hUHRF1|huNp95
Coordinate	chr19:4903080-4962154
Strand	+
Gene summary	This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Retrocopy(s) from UHRF1

Retroname	Coord	Strand	Genomic Region	ENSG
UHRF1P1	chr12:20551568-20554360	+	Intragenic	ENSG00000256663	UCSC

Expression

Transcript Sequences

>NM_001290052.2

TGGGCACCGAGGGGTCCCGGGGTCCGCGGATCTCGGGTGGGGTTTTTCCCTCTCAGTGGCACTTGGTTGAGTTCCCCCGGGACTTCTGAAGTTCCGGCCCGCGCTGGACTTCTGGGATTCCCTCTTCCCGCCGACACCATGTGGATCCAGGTTCGGACCATGGACGGGAGGCAGACCCACACGGTGGACTCGCTGTCCAGGCTGACCAAGGTGGAGGAGCTGAGGCGGAAGATCCAGGAGCTGTTCCACGTGGAGCCAGGCCTGCAGAGGCTGTTCTACAGGGGCAAACAGATGGAGGACGGCCATACCCTCTTCGACTACGAGGTCCGCCTGAATGACACCATCCAGCTCCTGGTCCGCCAGAGCCTCGTGCTCCCCCACAGCACCAAGGAGCGGGACTCCGAGCTCTCCGACACCGACTCCGGCTGCTGCCTGGGCCAGAGTGAGTCAGACAAGTCCTCCACCCACGGTGAGGCGGCCGCCGAGACTGACAGCAGGCCAGCCGATGAGGACATGTGGGATGAGACGGAATTGGGGCTGTACAAGGTCAATGAGTACGTCGATGCTCGGGACACGAACATGGGGGCGTGGTTTGAGGCGCAGGTGGTCAGGGTGACGCGGAAGGCCCCCTCCCGGGACGAGCCCTGCAGCTCCACGTCCAGGCCGGCGCTGGAGGAGGACGTCATTTACCACGTGAAATACGACGACTACCCGGAGAACGGCGTGGTCCAGATGAACTCCAGGGACGTCCGAGCGCGCGCCCGCACCATCATCAAGTGGCAGGACCTGGAGGTGGGCCAGGTGGTCATGCTCAACTACAACCCCGACAACCCCAAGGAGCGGGGCTTCTGGTACGACGCGGAGATCTCCAGGAAGCGCGAGACCAGGACGGCGCGGGAACTCTACGCCAACGTGGTGCTGGGGGATGATTCTCTGAACGACTGTCGGATCATCTTCGTGGACGAAGTCTTCAAGATTGAGCGGCCGGGTGAAGGGAGCCCCATGGTTGACAACCCCATGAGACGGAAGAGCGGGCCGTCCTGCAAGCACTGCAAGGACGACGTGAACAGACTCTGCCGGGTCTGCGCCTGCCACCTGTGCGGGGGCCGGCAGGACCCCGACAAGCAGCTCATGTGCGATGAGTGCGACATGGCCTTCCACATCTACTGCCTGGACCCGCCCCTCAGCAGTGTTCCCAGCGAGGACGAGTGGTACTGCCCTGAGTGCCGGAATGATGCCAGCGAGGTGGTACTGGCGGGAGAGCGGCTGAGAGAGAGCAAGAAGAAGGCGAAGATGGCCTCGGCCACATCGTCCTCACAGCGGGACTGGGGCAAGGGCATGGCCTGTGTGGGCCGCACCAAGGAATGTACCATCGTCCCGTCCAACCACTACGGACCCATCCCGGGGATCCCCGTGGGCACCATGTGGCGGTTCCGAGTCCAGGTCAGCGAGTCGGGTGTCCATCGGCCCCACGTGGCTGGCATACACGGCCGGAGCAACGACGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTATGAGGATGATGTGGACCATGGGAATTTTTTCACATACACGGGTAGTGGTGGTCGAGATCTTTCCGGCAACAAGAGGACCGCGGAACAGTCTTGTGATCAGAAACTCACCAACACCAACAGGGCGCTGGCTCTCAACTGCTTTGCTCCCATCAATGACCAAGAAGGGGCCGAGGCCAAGGACTGGCGGTCGGGGAAGCCGGTCAGGGTGGTGCGCAATGTCAAGGGTGGCAAGAATAGCAAGTACGCCCCCGCTGAGGGCAACCGCTACGATGGCATCTACAAGGTTGTGAAATACTGGCCCGAGAAGGGGAAGTCCGGGTTTCTCGTGTGGCGCTACCTTCTGCGGAGGGACGATGATGAGCCTGGCCCTTGGACGAAGGAGGGGAAGGACCGGATCAAGAAGCTGGGGCTGACCATGCAGTATCCAGAAGGCTACCTGGAAGCCCTGGCCAACCGAGAGCGAgagaaggagaacagcaagagggaggaggaggagcagcaggagggggGCTTCGCGTCCCCCAGGACGGGCAAGGGCAAGTGGAAGCGGAAGTCGGCAGGAGGTGGCCCGAGCAGGGCCGGGTCCCCGCGCCGGACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCACGGCCCAGCAGAGCAGCCTCATCAGAGAGGACAAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCACTCAAGGACCGGCCGGCGAGCGGCAGCCCGTTCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGTGTATCTGCTGTCAGGAGCTGGTGTTCCGGCCCATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTGCCTGGACAGATCCTTTCGGGCACAGGTGTTCAGCTGCCCTGCCTGCCGCTACGACCTGGGCCGCAGCTATGCCATGCAGGTGAACCAGCCTCTGCAGACCGTCCTCAACCAGCTCTTCCCCGGCTACGGCAATGGCCGGTGATCTCCAAGCACTTCTCGACAGGCGTTTTGCTGAAAACGTGTCGGAGGGCTCGTTCATCGGCACTGATTTTGTTCTTAGTGGGCTTAACTTAAACAGGTAGTGTTTCCTCCGTTCCCTAAAAAGGTTTGTCTTCCtttttttttttatttttatttttCAAATCTATACATTTTCAGGAATTTATGTATTCTGGCTAAAAGTTGGACTTCTCAGTATTGTGTTTAGTTCTTTGAAAACATAAAAGCCTGCAATTTCTCGACAAAACAACACAAGATTTTTTAAAGATGGAATCAGAAACTACGTGGTGTGGAGGCTGTTGATGTTTCTGGTGTCAAGTTCTCAGAAGTTGCTGCCACCAACTCTTTAAGAAGGCGACAGGATCAGTCCTTCTCTCGGGTTCTGGCCCCCAAGGTCAGAGCAAGCATCTTCCTGACAGCATTTTGTCATCTAAAGTCCAGTGACATGGTTCCCCGTGGTGGCCCGTGGCAGCCCGTGGCATGGCGTGGCTCAGCTGTCTGTTGAAGTTGTTGCAAGGAAAAGAGGAAACATCTCGGGCCTAGTTCAAACCTTTGCCTCAAAGCCATCCCCCACCAGACTGCTTAGCGTCTGAGATCCGCGTGAAAAGTCCTCTGCCCACGAGAGCAGGGAGTTGGGGCCACGCAGAAATGGCCTCAAGGGGACTCTGCTCCACGTGGGGCCAGGCGTGTGACTGACGCTGTCCGACGAAGGCGGCCACGGACGGACGCCAGCACACGAAGTCACGTGCAAGTGCCTTTGATTCGTTCCTTCTTTCTAAAGACGACAGTCTTTGTTGTTAGCACTGAATTATTGAAAATGTCAACCAGATTCTAGAAACTGCGGTCATCCAGTTCTTCCTGACACCGGATGGGTGCTTGGGAACCGTTTGAGCCTTATAGATCATTTACATTCAATTTTTTTAACTCAGCAAGTGAGAACTTACAAGAGGGTTTTTTTAAAATTTTTTTTTCTCTTAATGAACACATTTTCTAAATGAATTTTTTTTGTAGTTACTGTATATGTACCAAGAAAGATATAACGTTAGGGTTTGGttgtttttgtttttgtattttttttcttttGAAAGGGTTTGTTAATTTTTCTAATTTTACCAAAGTTTGCAGCCTATACCTCAATAAAACAGGGATATTTTAAATCACATACCTGCAGACAAACTGGAGCAATGTTATTTTTAAAGGGTTTTTTTCACCTCCTTATTCTTAGATTATTAATGTATTAGGGAAGAATGAGACAATTTTGTGTAGGCTTTTTCTAAAGTCCAGTACTTTGTCCAGATTTTAGATTCTCAGAATAAATGTTTTTCACAGATAGA