Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UHRF1P1
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Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:20551568-20554360  UCSC
Coordinates (T2T) chr12:20430030-20432823  UCSC
Coordinates (hg19) chr12:20704502-20707294  UCSC
Strand +
Parental Sequence NM_001290052.2
Parental seq. overlap 2658 bp
Parental seq. overlap (%) 68.6%
Genomic Region Intragenic (PDE3A)
Retrocopy Summary UHRF1P1, located on chr12:20551568-20554360, is a retrocopy of the parental gene UHRF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UHRF1
Full Name ubiquitin like with PHD and ring finger domains 1
Also known as ICBP90|Np95|RNF106|TDRD22|hNP95|hUHRF1|huNp95
Coordinate chr19:4903080-4962154
Strand +
Gene summary This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.51
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>UHRF1P1
GTGCGGGGGCCGGCAGGACCCCGACAAGCAGCTCATGTGCGATGAGTGCGACATGGCCTTCCACATCTACTGCCTGGACCCGCCCCTCAGCAGTGTTCCCAGCGAGGACGAGTGGTACTGCCCTGAGTGCCGGAATGATGCCAGCGAGGTGGTACTGGCGGGAGAGCGGCTGAGAGAGAGCAAGAAGAAGGCGAAGATGGCCTCGGCCACATCGTCCTCACAGCGGGACTGGGACAAGGGCATGGCCTGTGTGGGCCGCACCAAGGAATGTACCATCATCCCGTCCAACCACTACGGACCCATCCCGGGGATCCCCGTGGGCACCATGTGGCGGTTCCGAGTCCAGGTCAGCGAGTCGGGTGTCCATCGGCCCCACGTGGCTGGCATCCATGGCCGGAGCAACGACGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTACGAGGATGACGTGGACCATGGGAATTTTTTCACATACACGGGTAGTGGTGGTCGAGAGCTTTCCGGCAACAAGAGGACCGCGGAACAGTCTTGTGATCAGAAACTCACCAACACCAACAGGGCGCTGGCTCTCAACTGCTTTGCTCCCATCAATGACCAAGAAGGGGCCGAGGCCAAGGACTGGCGGTCGGGGAAGCCGGTCAGGGTGGTGCGCAATGTCAAGGGTGGCAAGAATAGCAAGTACGCCCCCGCTGAGGGCAACCGCTACGATGGCATCTACAAGGTTGTGAAATACTGGCCCGAGAAGGGGAAGTCCGGGTTTCTCGTGTGGCGCTACCTTCTGCGGAGGGACGATGATGAGCCCGGCCCTTGGACGAAGGAGGGGAAGGACCGGATCAAGAAGCTGGGGCTGACCATGCAGTATCCAGAAGGCTACCTGGAAGCCCTGGCCAACCGAGAGCGAGCTTCGCGTCCCCCAGGACGGGCAAGGGCAAGTGGAAGCGGAAGTCGGCAGGAGGTGGCCCGAGCAGGGCCGGGTCCCCGCGCCGGACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCACGGCCCAGCAGAGCAGCCTCATCAGAGAGGACAAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCACTCAAGGACCGGCCGGCGAGCGGCAGCCCGTTCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGTGTATCTGCTGTCAGGAGCTGGTGTTCCGGCCCATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTGCCTGGACAGATCCTTTCGGGCACAGGTGTTCAGCTGCCCTGCCTGCCGCTACGACCTGGGCCGCAGCTATGCCATGCAGGTGAACCAGCCTCTGCAGACCGTCCTCAACCAGCTCTTCCCCGGCTACGGCAATGGCCGGTGATCTCCAAGCACTTCTCGACAGGCGTTTTGCTGAAAACGTGTCGGAGGGCTCGTTCATCGGCACTGATTTTGTTCTTAGTGGGCTTAACTTAAACAGGTAGTGTTTCCTCCGTTCCCTAAAAAGGTTTGTCTTCCCAAATCTATACATTTTCAGGAATTTATGTATTCTGGCTAAAAGTTGGACTTCTCAGTATTGTGTTTAGTTCTTTGAAAACATAAAAGCCTGCAATTTCTCGACAAAACAACACAAGATTTTTTAAAGATGGAATCAGAAACTACGTGGTGTGGAGGCTGTTGATGTTTCTGGTGTCAAGTTCTCAGAAGTTGCTGCCACCAACTCTTTAAGAAGGCGACAGGATCAGTCCTTCTCTCGGGTTCTGGCCCCCAAGGTCAGAGCAAGCATCTTCCTGACAGCATTTTGTCATCTAAAGTCCAGTGACATGGTTCCCCGTGGTGGCCCGTGGCAGCCCGTGGCATGGCGTGGCTCAGCTGTCTGTTGAAGTTGTTGCAAGGAAAAGAGGAAACATCTCGGGCCTAGTTCAAACCTTTGCCTCAAAGCCATCCCCCACCAGACTGCTTAGCGTCTGAGATCCGCGTGAAAAGTCCTCTGCCCACGAGAGCAGGGAGTTGGGGCCACGCAGAAATGGCCTCAAGGGGACTCCGCTCCACGTGGGGCCAGGCGTGTGGCTGACGCTGTCCGACGAAGGCGGCCACGGACGGACGCCAGCACATGAAGTCACGTGCAAGTGCCTTTGATTCGTTCCTTCTTTCTAAAGACGACAGTCTTTGTTGTTAGCACTGAATTATTGAAAATGTCAACCAGATTCTAGAAACTGCGGTCATCCAGTTCTTCCTGACACCGGATGGGTGCTTGGGAACCGTTTGAGCCTTATAGATCATTTACATTCAATTTTTTTAACTCAGCAAGTGAGAACTTACAAGAGGGTTTTTTTTTTAATTTTTTTTTCTCTTAATGAACACATTTTCTAAATGAATTTTTTTGTAGTTACTGTATATGTACCAAGAAAGATATAACGTTAGGGTTTGGGAAAGGGTTTGTTAATTTTTCTAATTTTACCAAAGTTTGCAGCCTATACCTCAATAAAACAGGGATATTTTAAATCACATACCTGCAGACAAACTGGAGCAATGTTATTTTTAAAGGGTTTTTTTTCACCTCCTTATTCTTAGATTATTAATGTATTAGGGAAGAATGAGACAATTTTGTGTAGGCTTTTTCTAAAGTCCAGTACTTTGTCCAGATTTTAGATTCTCAGAATAAATGTTTTTCACAGAT
>NM_001290052.2
TGGGCACCGAGGGGTCCCGGGGTCCGCGGATCTCGGGTGGGGTTTTTCCCTCTCAGTGGCACTTGGTTGAGTTCCCCCGGGACTTCTGAAGTTCCGGCCCGCGCTGGACTTCTGGGATTCCCTCTTCCCGCCGACACCATGTGGATCCAGGTTCGGACCATGGACGGGAGGCAGACCCACACGGTGGACTCGCTGTCCAGGCTGACCAAGGTGGAGGAGCTGAGGCGGAAGATCCAGGAGCTGTTCCACGTGGAGCCAGGCCTGCAGAGGCTGTTCTACAGGGGCAAACAGATGGAGGACGGCCATACCCTCTTCGACTACGAGGTCCGCCTGAATGACACCATCCAGCTCCTGGTCCGCCAGAGCCTCGTGCTCCCCCACAGCACCAAGGAGCGGGACTCCGAGCTCTCCGACACCGACTCCGGCTGCTGCCTGGGCCAGAGTGAGTCAGACAAGTCCTCCACCCACGGTGAGGCGGCCGCCGAGACTGACAGCAGGCCAGCCGATGAGGACATGTGGGATGAGACGGAATTGGGGCTGTACAAGGTCAATGAGTACGTCGATGCTCGGGACACGAACATGGGGGCGTGGTTTGAGGCGCAGGTGGTCAGGGTGACGCGGAAGGCCCCCTCCCGGGACGAGCCCTGCAGCTCCACGTCCAGGCCGGCGCTGGAGGAGGACGTCATTTACCACGTGAAATACGACGACTACCCGGAGAACGGCGTGGTCCAGATGAACTCCAGGGACGTCCGAGCGCGCGCCCGCACCATCATCAAGTGGCAGGACCTGGAGGTGGGCCAGGTGGTCATGCTCAACTACAACCCCGACAACCCCAAGGAGCGGGGCTTCTGGTACGACGCGGAGATCTCCAGGAAGCGCGAGACCAGGACGGCGCGGGAACTCTACGCCAACGTGGTGCTGGGGGATGATTCTCTGAACGACTGTCGGATCATCTTCGTGGACGAAGTCTTCAAGATTGAGCGGCCGGGTGAAGGGAGCCCCATGGTTGACAACCCCATGAGACGGAAGAGCGGGCCGTCCTGCAAGCACTGCAAGGACGACGTGAACAGACTCTGCCGGGTCTGCGCCTGCCACCTGTGCGGGGGCCGGCAGGACCCCGACAAGCAGCTCATGTGCGATGAGTGCGACATGGCCTTCCACATCTACTGCCTGGACCCGCCCCTCAGCAGTGTTCCCAGCGAGGACGAGTGGTACTGCCCTGAGTGCCGGAATGATGCCAGCGAGGTGGTACTGGCGGGAGAGCGGCTGAGAGAGAGCAAGAAGAAGGCGAAGATGGCCTCGGCCACATCGTCCTCACAGCGGGACTGGGGCAAGGGCATGGCCTGTGTGGGCCGCACCAAGGAATGTACCATCGTCCCGTCCAACCACTACGGACCCATCCCGGGGATCCCCGTGGGCACCATGTGGCGGTTCCGAGTCCAGGTCAGCGAGTCGGGTGTCCATCGGCCCCACGTGGCTGGCATACACGGCCGGAGCAACGACGGAGCGTACTCCCTAGTCCTGGCGGGGGGCTATGAGGATGATGTGGACCATGGGAATTTTTTCACATACACGGGTAGTGGTGGTCGAGATCTTTCCGGCAACAAGAGGACCGCGGAACAGTCTTGTGATCAGAAACTCACCAACACCAACAGGGCGCTGGCTCTCAACTGCTTTGCTCCCATCAATGACCAAGAAGGGGCCGAGGCCAAGGACTGGCGGTCGGGGAAGCCGGTCAGGGTGGTGCGCAATGTCAAGGGTGGCAAGAATAGCAAGTACGCCCCCGCTGAGGGCAACCGCTACGATGGCATCTACAAGGTTGTGAAATACTGGCCCGAGAAGGGGAAGTCCGGGTTTCTCGTGTGGCGCTACCTTCTGCGGAGGGACGATGATGAGCCTGGCCCTTGGACGAAGGAGGGGAAGGACCGGATCAAGAAGCTGGGGCTGACCATGCAGTATCCAGAAGGCTACCTGGAAGCCCTGGCCAACCGAGAGCGAgagaaggagaacagcaagagggaggaggaggagcagcaggagggggGCTTCGCGTCCCCCAGGACGGGCAAGGGCAAGTGGAAGCGGAAGTCGGCAGGAGGTGGCCCGAGCAGGGCCGGGTCCCCGCGCCGGACATCCAAGAAAACCAAGGTGGAGCCCTACAGTCTCACGGCCCAGCAGAGCAGCCTCATCAGAGAGGACAAGAGCAACGCCAAGCTGTGGAATGAGGTCCTGGCGTCACTCAAGGACCGGCCGGCGAGCGGCAGCCCGTTCCAGTTGTTCCTGAGTAAAGTGGAGGAGACGTTCCAGTGTATCTGCTGTCAGGAGCTGGTGTTCCGGCCCATCACGACCGTGTGCCAGCACAACGTGTGCAAGGACTGCCTGGACAGATCCTTTCGGGCACAGGTGTTCAGCTGCCCTGCCTGCCGCTACGACCTGGGCCGCAGCTATGCCATGCAGGTGAACCAGCCTCTGCAGACCGTCCTCAACCAGCTCTTCCCCGGCTACGGCAATGGCCGGTGATCTCCAAGCACTTCTCGACAGGCGTTTTGCTGAAAACGTGTCGGAGGGCTCGTTCATCGGCACTGATTTTGTTCTTAGTGGGCTTAACTTAAACAGGTAGTGTTTCCTCCGTTCCCTAAAAAGGTTTGTCTTCCtttttttttttatttttatttttCAAATCTATACATTTTCAGGAATTTATGTATTCTGGCTAAAAGTTGGACTTCTCAGTATTGTGTTTAGTTCTTTGAAAACATAAAAGCCTGCAATTTCTCGACAAAACAACACAAGATTTTTTAAAGATGGAATCAGAAACTACGTGGTGTGGAGGCTGTTGATGTTTCTGGTGTCAAGTTCTCAGAAGTTGCTGCCACCAACTCTTTAAGAAGGCGACAGGATCAGTCCTTCTCTCGGGTTCTGGCCCCCAAGGTCAGAGCAAGCATCTTCCTGACAGCATTTTGTCATCTAAAGTCCAGTGACATGGTTCCCCGTGGTGGCCCGTGGCAGCCCGTGGCATGGCGTGGCTCAGCTGTCTGTTGAAGTTGTTGCAAGGAAAAGAGGAAACATCTCGGGCCTAGTTCAAACCTTTGCCTCAAAGCCATCCCCCACCAGACTGCTTAGCGTCTGAGATCCGCGTGAAAAGTCCTCTGCCCACGAGAGCAGGGAGTTGGGGCCACGCAGAAATGGCCTCAAGGGGACTCTGCTCCACGTGGGGCCAGGCGTGTGACTGACGCTGTCCGACGAAGGCGGCCACGGACGGACGCCAGCACACGAAGTCACGTGCAAGTGCCTTTGATTCGTTCCTTCTTTCTAAAGACGACAGTCTTTGTTGTTAGCACTGAATTATTGAAAATGTCAACCAGATTCTAGAAACTGCGGTCATCCAGTTCTTCCTGACACCGGATGGGTGCTTGGGAACCGTTTGAGCCTTATAGATCATTTACATTCAATTTTTTTAACTCAGCAAGTGAGAACTTACAAGAGGGTTTTTTTAAAATTTTTTTTTCTCTTAATGAACACATTTTCTAAATGAATTTTTTTTGTAGTTACTGTATATGTACCAAGAAAGATATAACGTTAGGGTTTGGttgtttttgtttttgtattttttttcttttGAAAGGGTTTGTTAATTTTTCTAATTTTACCAAAGTTTGCAGCCTATACCTCAATAAAACAGGGATATTTTAAATCACATACCTGCAGACAAACTGGAGCAATGTTATTTTTAAAGGGTTTTTTTCACCTCCTTATTCTTAGATTATTAATGTATTAGGGAAGAATGAGACAATTTTGTGTAGGCTTTTTCTAAAGTCCAGTACTTTGTCCAGATTTTAGATTCTCAGAATAAATGTTTTTCACAGATAGA

Publications

PMID - Link Title
No publications available for this retrocopy