| Gene Name | LIMK2 |
|
| Specie | Homo sapiens | |
| Full Name | LIM domain kinase 2 | |
| Also known as | - | |
| Coordinate | chr22:31212298-31280080 | |
| Strand | + | |
| Gene summary | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Retroname | Coord | Strand | Genomic Region | ENSG | |
|---|---|---|---|---|---|
| LIMK2P1 | chrX:11703494-11705613 | - |
Intergenic |
ENSG00000223418 | UCSC |
| >NM_005569.4 |
| GTCTTCCCGCGCCTGAGGCGGCGGCGGCAGGAGCTGAGGGGAGTTGTAGGGAACTGAGGGGAGCTGCTGTGTCCCCCGCCTCCTCCTCCCCATTTCCGCGCTCCCGGGACCATGTCCGCGCTGGCGGGTGAAGATGTCTGGAGGTGTCCAGGCTGTGGGGACCACATTGCTCCAAGCCAGATATGGTACAGGACTGTCAACGAAACCTGGCACGGCTCTTGCTTCCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCTTTTATGGTGGCTGGGGAGTTCAAGTACCACCCAGAGTGCTTTGCCTGTATGAGCTGCAAGGTGATCATTGAGGATGGGGATGCATATGCACTGGTGCAGCATGCCACCCTCTACTGTGGGAAGTGCCACAATGAGGTGGTGCTGGCACCCATGTTTGAGAGACTCTCCACAGAGTCTGTTCAGGAGCAGCTGCCCTACTCTGTCACGCTCATCTCCATGCCGGCCACCACTGAAGGCAGGCGGGGCTTCTCCGTGTCCGTGGAGAGTGCCTGCTCCAACTACGCCACCACTGTGCAAGTGAAAGAGGTCAACCGGATGCACATCAGTCCCAACAATCGAAACGCCATCCACCCTGGGGACCGCATCCTGGAGATCAATGGGACCCCCGTCCGCACACTTCGAGTGGAGGAGGTGGAGGATGCAATTAGCCAGACGAGCCAGACACTTCAGCTGTTGATTGAACATGACCCCGTCTCCCAACGCCTGGACCAGCTGCGGCTGGAGGCCCGGCTCGCTCCTCACATGCAGAATGCCGGACACCCCCACGCCCTCAGCACCCTGGACACCAAGGAGAATCTGGAGGGGACACTGAGGAGACGTTCCCTAAGGCGCAGTAACAGTATCTCCAAGTCCCCTGGCCCCAGCTCCCCAAAGGAGCCCCTGCTGTTCAGCCGTGACATCAGCCGCTCAGAATCCCTTCGTTGTTCCAGCAGCTATTCACAGCAGATCTTCCGGCCCTGTGACCTAATCCATGGGGAGGTCCTGGGGAAGGGCTTCTTTGGGCAGGCTATCAAGGTGACACACAAAGCCACGGGCAAAGTGATGGTCATGAAAGAGTTAATTCGATGTGATGAGGAGACCCAGAAAACTTTTCTGACTGAGGTGAAAGTGATGCGCAGCCTGGACCACCCCAATGTGCTCAAGTTCATTGGTGTGCTGTACAAGGATAAGAAGCTGAACCTCCTGACAGAGTACATTGAGGGGGGCACACTGAAGGACTTTCTGCGCAGTATGGATCCGTTCCCCTGGCAGCAGAAGGTCAGGTTTGCCAAAGGAATCGCCTCCGGAATGGCCTATTTGCACTCTATGTGCATCATCCACCGGGATCTGAACTCGCACAACTGCCTCATCAAGTTGGACAAGACTGTGGTGGTGGCAGACTTTGGGCTGTCACGGCTCATAGTGGAAGAGAGGAAAAGGGCCCCCATGGAGAAGGCCACCACCAAGAAACGCACCTTGCGCAAGAACGACCGCAAGAAGCGCTACACGGTGGTGGGAAACCCCTACTGGATGGCCCCTGAGATGCTGAACGGAAAGAGCTATGATGAGACGGTGGATATCTTCTCCTTTGGGATCGTTCTCTGTGAGATCATTGGGCAGGTGTATGCAGATCCTGACTGCCTTCCCCGAACACTGGACTTTGGCCTCAACGTGAAGCTTTTCTGGGAGAAGTTTGTTCCCACAGATTGTCCCCCGGCCTTCTTCCCGCTGGCCGCCATCTGCTGCAGACTGGAGCCTGAGAGCAGACCAGCATTCTCGAAATTGGAGGACTCCTTTGAGGCCCTCTCCCTGTACCTGGGGGAGCTGGGCATCCCGCTGCCTGCAGAGCTGGAGGAGTTGGACCACACTGTGAGCATGCAGTACGGCCTGACCCGGGACTCACCTCCCTAGCCCTGGCCCAGCCCCCTGCAGGGGGGTGTTCTACAGCCAGCATTGCCCCTCTGTGCCCCATTCCTGCTGTGAGCAGGGCCGTCCGGGCTTCCTGTGGATTGGCGGAATGTTTAGAAGCAGAACAAGCCATTCCTATTACCTCCCCAGGAGGCAAGTGGGCGCAGCACCAGGGAAATGTATCTCCACAGGTTCTGGGGCCTAGTTACTGTCTGTAAATCCAATACTTGCCTGAAAGCTGTGAAGAAGAAAAAAACCCCTGGCCTTTGGGCCAGGAGGAATCTGTTACTCGAATCCACCCAGGAACTCCCTGGCAGTGGATTGTGGGAGGCTCTTGCTTACACTAATCAGCGTGACCTGGACCTGCTGGGCAGGATCCCAGGGTGAACCTGCCTGTGAACTCTGAAGTCACTAGTCCAGCTGGGTGCAGGAGGACTTCAAGTGTGTGGACGAAAGAAAGACTGATGGCTCAAAGGGTGTGAAAAAGTCAGTGATGCTCCCCCTTTCTACTCCAGATCCTGTCCTTCCTGGAGCAAGGTTGAGGGAGTAGGTTTTGAAGAGTCCCTTAATATGTGGTGGAACAGGCCAGGAGTTAGAGAAAGGGCTGGCTTCTGTTTACCTGCTCACTGGCTCTAGCCAGCCCAGGGACCACATCAATGTGAGAGGAAGCCTCCACCTCATGTTTTCAAACTTAATACTGGAGACTGGCTGAGAACTTACGGACAACATCCTTTCTGTCTGAAACAAACAGTCACAAGCAAAGGAAGAGGCTGGGGGACTAGAAAGAGGCCCTGCCCTCTAGAAAGCTCAGATCTTGGCTTCTGTTACTCATACTCGGGTGGGCTCCTTAGTCAGATGCCTAAAACATTTTGCCTAAAGCTCGATGGGTTCTGGAGGACAGTGTGGCTTGTCACAGGCCTAGAGTCTGAGGGAGGGGAGTGGGAGTCTCAGCAATCTCTTGGTCTTGGCTTCATGGCAACCACTGCTCACCCTTCAACATGCCTGGTTTAGGCAGCAGCTTGGGCTGGGAAGAGGTGGTGGCAGAGTCTCAAAGCTGAGATGCTGAGAGAGATAGCTCCCTGAGCTGGGCCATCTGACTTCTACCTCCCATGTTTGCTCTCCCAACTCATTAGCTCCTGGGCAGCATCCTCCTGAGCCACATGTGCAGGTACTGGAAAACCTCCATCTTGGCTCCCAGAGCTCTAGGAACTCTTCATCACAACTAGATTTGCCTCTTCTAAGTGTCTATGAGCTTGCACCATATTTAATAAATTGGGAATGGGTTTGGGGTATTAATGCAATGTGTGGTGGTTGTATTGGAGCAGGGGGAATTGATAAAGGAGAGTGGTTGCTGTTAATATTATCTTATCTATTGGGTGGTATGTGAAATATTGTACATAGACCTGATGAGTTGTGGGACCAGATGTCATCTCTGGTCAGAGTTTACTTGCTATATAGACTGTACTTATGTGTGAAGTTTGCAAGCTTGCTTTAGGGCTGAGCCCTGGACTCCCAGCAGCAGCACAGTTCAGCATTGTGTGGCTGGTTGTTTCCTGGCTGTCCCCAGCAAGTGTAGGAGTGGTGGGCCTGAACTGGGCCATTGATCAGACTAAATAAATTAAGCAGTTAACATAACTGGCAA |