Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LIMK2P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:11703494-11705613  UCSC
Coordinates (T2T) chrX:11286041-11288160  UCSC
Coordinates (hg19) chrX:11721614-11723733  UCSC
Strand -
Parental Sequence NM_005569.4
Parental seq. overlap 1572 bp
Parental seq. overlap (%) 42.6%
Genomic Region Intergenic
Retrocopy Summary LIMK2P1, located on chrX:11703494-11705613, is a retrocopy of the parental gene LIMK2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LIMK2
Full Name LIM domain kinase 2
Also known as -
Coordinate chr22:31212298-31280080
Strand +
Gene summary There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LIMK2P1
Bonobo Pan paniscus LIMK2P1
Gorilla Gorilla gorilla LIMK2P1
Orangutan Pongo abelii LIMK2P1
Gibbon Nomascus leucogenys LIMK2P1
Green monkey Chlorocebus sabaeus LIMK2P1
Crab-eating macaque Macaca fascicularis LIMK2P1
Rhesus Macaca mulatta LIMK2P1
Baboon Papio anubis LIMK2P1
Golden snub-nosed monkey Rhinopithecus roxellana LIMK2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LIMK2P1
GCAGAACAAGCCATCTCTTCTATCTCCCCAGGAGACGAATGGATGCAGCACCAGGAAAATGTATCTCCACAGGTTTGAGGGCCTGGTTACTGTCTGCAAATCCAGCACTCACCTGAAAGCTGTGAAGAAGACAAAAAAAAAAGCCCGGCCTTTGGGCCAGGAGGAAATCTGTTACTCGGATCCACCCAGGAGGGGAGTTCAAGTACCATCCAGAATGCTTTGCCTGTGTGAGCTATAAGGTGACCATTGAGGATGGGGATGCATACGCCCTGGTGCTGCGTGTCACCCTATACTGTGGAAAGTGCCACAAATGAGGTGGTGCTGGCACCCATATTTGAGATACTCTCCACAGAGTCCATTCAGGACCAGCTGCCCTACTCTGTCATGCTCATGTCCATGCTGGCCATCACAGAGGGCAGGCGGAGCTTCTCCGTGTCCGTGGAGAATGCCTGCTCCAACTATGTTACCACCGTGCAAGTAAAAGAGGTCAACCAGATGCACATCAGTCCCAACAGCTGCAATGCCATCCACCCCAGGGACCACATCCTGGAGATCAGTGGAACCCCCACCCACACACTCCAAGTAGAGGAGTTGGAGGATGCAATTAGCCAGATGAGCCAGACACTTCTGCTGTTGATTGAACATGACCCTGTCTCCCGGTCCCCAGCCCAGCTGCGGCTGGATGCCTGGCTCTCTCCCCACACACAGAATGCTGGACACCCTCACGCCCTCAGCACCCTGGACACCAAGGATAATCTGGAGGGGACACTGAGAAGATGCTCCCTAAGACTCAGTAACAGCATCTCCAAGTCCCCTAGCCCTAGCTCTCCAAAGGAGCCCCTGCTGCTCAGCCGTGACATCAGCTGCTGGGAATCCCTTTGTTGTTCCAGCACTTACTCAAAGCAGAACTTCCGGTCCTGTGACCTGATCCACGGGGAGGTCCTGGGGAAGGGCTTCTTTGGGCAGGCTATCAAAGTGACACACAAAGCCACAGGCAAAGTGTTGGTCATGAAGGAATTAATGCGATGTGATGAGGAGAACCAGAAGACTTTTCTGACTGAAGTGAAAGTGACGTGAAGCCTGGACCACCCCAATGTGCTCAAGTTCATTGGCGTGCTGTACAAGGACAAGAAGCTGAACCTGCTGAGAGGACATTGAGGGGGGCATGCTGAAGGACCTTCTGCAAAGTGTGGACCCATTCCCCTGGCAGCAGGAAGTCAGCTTGGCCAAAGGCATTGCCTCCAGAATGGCCACCACCAAGAAATGTACTTTGCACAAGAACAACTTCAAGAAGTGCTACATGGTGGTGGGAAACCTCTACTGGATGATACCTGAGATGCTGAATGGAAAGAGCTATGACGAAATGTGGATGTATTCTCTTTTGGGATCGTTCTCTGTGAGACCATTGGGCAGGTGTATGCAGATCCCGATTTCCTTCCCCAAACACTGGACTTTGGCCTCAGCATGATGCTTTTCTGGGAGAAGTCTGTCCCCACAGACTGCCCTCCAACCTTCTTCCCCCTGGCCATGATCTACTGCAGACTGGAGCCCGAGAGCAGACTGGCATTCTCAAAACTGGAGGACTCTCTGTACCTGGGGGAGCTGGGCATCCCGCCGCCTGTAGGGCTGGAGGAGTTGGACCACACTGTGAGCATGCAGTACGGCCTGATCCAAGACTCACCCCACTAGCCCTGGCCCAGCCCCCTGCAGGGGGGTGTTCCACAGCCAGCATTGCTCCTCTGTTCTCCATCCCTGCTGTGAGCAGGGTTTTTCGGGCTTCCCGTGGATTGGCAGCTTGTTTAGAAGCAGAACAAGCCg
>NM_005569.4
GTCTTCCCGCGCCTGAGGCGGCGGCGGCAGGAGCTGAGGGGAGTTGTAGGGAACTGAGGGGAGCTGCTGTGTCCCCCGCCTCCTCCTCCCCATTTCCGCGCTCCCGGGACCATGTCCGCGCTGGCGGGTGAAGATGTCTGGAGGTGTCCAGGCTGTGGGGACCACATTGCTCCAAGCCAGATATGGTACAGGACTGTCAACGAAACCTGGCACGGCTCTTGCTTCCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCTTTTATGGTGGCTGGGGAGTTCAAGTACCACCCAGAGTGCTTTGCCTGTATGAGCTGCAAGGTGATCATTGAGGATGGGGATGCATATGCACTGGTGCAGCATGCCACCCTCTACTGTGGGAAGTGCCACAATGAGGTGGTGCTGGCACCCATGTTTGAGAGACTCTCCACAGAGTCTGTTCAGGAGCAGCTGCCCTACTCTGTCACGCTCATCTCCATGCCGGCCACCACTGAAGGCAGGCGGGGCTTCTCCGTGTCCGTGGAGAGTGCCTGCTCCAACTACGCCACCACTGTGCAAGTGAAAGAGGTCAACCGGATGCACATCAGTCCCAACAATCGAAACGCCATCCACCCTGGGGACCGCATCCTGGAGATCAATGGGACCCCCGTCCGCACACTTCGAGTGGAGGAGGTGGAGGATGCAATTAGCCAGACGAGCCAGACACTTCAGCTGTTGATTGAACATGACCCCGTCTCCCAACGCCTGGACCAGCTGCGGCTGGAGGCCCGGCTCGCTCCTCACATGCAGAATGCCGGACACCCCCACGCCCTCAGCACCCTGGACACCAAGGAGAATCTGGAGGGGACACTGAGGAGACGTTCCCTAAGGCGCAGTAACAGTATCTCCAAGTCCCCTGGCCCCAGCTCCCCAAAGGAGCCCCTGCTGTTCAGCCGTGACATCAGCCGCTCAGAATCCCTTCGTTGTTCCAGCAGCTATTCACAGCAGATCTTCCGGCCCTGTGACCTAATCCATGGGGAGGTCCTGGGGAAGGGCTTCTTTGGGCAGGCTATCAAGGTGACACACAAAGCCACGGGCAAAGTGATGGTCATGAAAGAGTTAATTCGATGTGATGAGGAGACCCAGAAAACTTTTCTGACTGAGGTGAAAGTGATGCGCAGCCTGGACCACCCCAATGTGCTCAAGTTCATTGGTGTGCTGTACAAGGATAAGAAGCTGAACCTCCTGACAGAGTACATTGAGGGGGGCACACTGAAGGACTTTCTGCGCAGTATGGATCCGTTCCCCTGGCAGCAGAAGGTCAGGTTTGCCAAAGGAATCGCCTCCGGAATGGCCTATTTGCACTCTATGTGCATCATCCACCGGGATCTGAACTCGCACAACTGCCTCATCAAGTTGGACAAGACTGTGGTGGTGGCAGACTTTGGGCTGTCACGGCTCATAGTGGAAGAGAGGAAAAGGGCCCCCATGGAGAAGGCCACCACCAAGAAACGCACCTTGCGCAAGAACGACCGCAAGAAGCGCTACACGGTGGTGGGAAACCCCTACTGGATGGCCCCTGAGATGCTGAACGGAAAGAGCTATGATGAGACGGTGGATATCTTCTCCTTTGGGATCGTTCTCTGTGAGATCATTGGGCAGGTGTATGCAGATCCTGACTGCCTTCCCCGAACACTGGACTTTGGCCTCAACGTGAAGCTTTTCTGGGAGAAGTTTGTTCCCACAGATTGTCCCCCGGCCTTCTTCCCGCTGGCCGCCATCTGCTGCAGACTGGAGCCTGAGAGCAGACCAGCATTCTCGAAATTGGAGGACTCCTTTGAGGCCCTCTCCCTGTACCTGGGGGAGCTGGGCATCCCGCTGCCTGCAGAGCTGGAGGAGTTGGACCACACTGTGAGCATGCAGTACGGCCTGACCCGGGACTCACCTCCCTAGCCCTGGCCCAGCCCCCTGCAGGGGGGTGTTCTACAGCCAGCATTGCCCCTCTGTGCCCCATTCCTGCTGTGAGCAGGGCCGTCCGGGCTTCCTGTGGATTGGCGGAATGTTTAGAAGCAGAACAAGCCATTCCTATTACCTCCCCAGGAGGCAAGTGGGCGCAGCACCAGGGAAATGTATCTCCACAGGTTCTGGGGCCTAGTTACTGTCTGTAAATCCAATACTTGCCTGAAAGCTGTGAAGAAGAAAAAAACCCCTGGCCTTTGGGCCAGGAGGAATCTGTTACTCGAATCCACCCAGGAACTCCCTGGCAGTGGATTGTGGGAGGCTCTTGCTTACACTAATCAGCGTGACCTGGACCTGCTGGGCAGGATCCCAGGGTGAACCTGCCTGTGAACTCTGAAGTCACTAGTCCAGCTGGGTGCAGGAGGACTTCAAGTGTGTGGACGAAAGAAAGACTGATGGCTCAAAGGGTGTGAAAAAGTCAGTGATGCTCCCCCTTTCTACTCCAGATCCTGTCCTTCCTGGAGCAAGGTTGAGGGAGTAGGTTTTGAAGAGTCCCTTAATATGTGGTGGAACAGGCCAGGAGTTAGAGAAAGGGCTGGCTTCTGTTTACCTGCTCACTGGCTCTAGCCAGCCCAGGGACCACATCAATGTGAGAGGAAGCCTCCACCTCATGTTTTCAAACTTAATACTGGAGACTGGCTGAGAACTTACGGACAACATCCTTTCTGTCTGAAACAAACAGTCACAAGCAAAGGAAGAGGCTGGGGGACTAGAAAGAGGCCCTGCCCTCTAGAAAGCTCAGATCTTGGCTTCTGTTACTCATACTCGGGTGGGCTCCTTAGTCAGATGCCTAAAACATTTTGCCTAAAGCTCGATGGGTTCTGGAGGACAGTGTGGCTTGTCACAGGCCTAGAGTCTGAGGGAGGGGAGTGGGAGTCTCAGCAATCTCTTGGTCTTGGCTTCATGGCAACCACTGCTCACCCTTCAACATGCCTGGTTTAGGCAGCAGCTTGGGCTGGGAAGAGGTGGTGGCAGAGTCTCAAAGCTGAGATGCTGAGAGAGATAGCTCCCTGAGCTGGGCCATCTGACTTCTACCTCCCATGTTTGCTCTCCCAACTCATTAGCTCCTGGGCAGCATCCTCCTGAGCCACATGTGCAGGTACTGGAAAACCTCCATCTTGGCTCCCAGAGCTCTAGGAACTCTTCATCACAACTAGATTTGCCTCTTCTAAGTGTCTATGAGCTTGCACCATATTTAATAAATTGGGAATGGGTTTGGGGTATTAATGCAATGTGTGGTGGTTGTATTGGAGCAGGGGGAATTGATAAAGGAGAGTGGTTGCTGTTAATATTATCTTATCTATTGGGTGGTATGTGAAATATTGTACATAGACCTGATGAGTTGTGGGACCAGATGTCATCTCTGGTCAGAGTTTACTTGCTATATAGACTGTACTTATGTGTGAAGTTTGCAAGCTTGCTTTAGGGCTGAGCCCTGGACTCCCAGCAGCAGCACAGTTCAGCATTGTGTGGCTGGTTGTTTCCTGGCTGTCCCCAGCAAGTGTAGGAGTGGTGGGCCTGAACTGGGCCATTGATCAGACTAAATAAATTAAGCAGTTAACATAACTGGCAA

Publications

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